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已发表论文
用于结直肠癌伊立替康/姜黄素共递送的工程化癌细胞膜功能化金属有机框架：增强疗效和减轻毒性
Authors Jin S, Zhou A, Zhang Q, Zhao D, Dong X, Meng HM, Yu Z, Li Z
Received 6 August 2025
Accepted for publication 12 November 2025
Published 19 November 2025 Volume 2025:20 Pages 13857—13869
DOI https://doi.org/10.2147/IJN.S558675
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Professor Dong Wang
Shuiling Jin,1,* Aifang Zhou,2,* Qi Zhang,1,* Di Zhao,2 Xintong Dong,2 Hong-Min Meng,2 Zhengquan Yu,1 Zhaohui Li1
1The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, People’s Republic of China; 2College of Chemistry, Zhengzhou University, Zhengzhou, Henan Province, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Hong-Min Meng, College of Chemistry, Zhengzhou University, Zhengzhou, Henan Province, People’s Republic of China, 450001, Email hmmeng2017@zzu.edu.cn Zhaohui Li, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, People’s Republic of China, 450052, Email zhaohui.li@zzu.edu.cn
Purpose: Irinotecan (CPT-11), a semisynthetic camptothecin derivative and topoisomerase I inhibitor, is globally used for treating cancers such as colorectal cancer. However, its clinical application is limited by severe adverse effects, including diarrhea and myelosuppression. Biomimetic nano-drug delivery is widely used and can improve chemotherapeutic activity and decrease side effects.
Methods: In this study, we developed a cancer cell membrane-functionalized metal-organic frameworks for irinotecan/curcumin (named MZCC) for colorectal cancer treatment. In this study, by combining irinotecan, curcumin, MOFs and functionalized cancer cell membrane, a pH-sensitive drug delivery system of MZCC was developed for colorectal cancer treatment with enhanced chemotherapeutic efficacy while reducing side effects. The characteristics and stability of MZCC were carefully examined, and its anti-cancer efficiency was studied in vitro and in vivo. In vivo experiments in a murine colorectal cancer mouse model given intratumorally MZCC injection every 4 days were used to assess antitumor efficacy and systemic toxicity.
Results: The MZCC system improved treatment antitumor efficacy by 2.3-fold compared with free CPT-11 through synergistic chemotherapy. MZCC-treated groups exhibited a significant reduction in inflammatory cytokine levels within colon tissues; inflammation levels decreased by 55% compared with free CPT-11, and colon length was restored to 79% of normal.
Conclusion: Our strategy effectively alleviates CPT-11-induced intestinal toxicity and mitigates adverse reactions. This approach may provide a novel method for enhancing chemotherapeutic efficacy while reducing gastrointestinal toxicity.
Keywords: colorectal cancer, irinotecan, curcumin, metal-organic frameworks, cell membrane
1The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, People’s Republic of China; 2College of Chemistry, Zhengzhou University, Zhengzhou, Henan Province, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Hong-Min Meng, College of Chemistry, Zhengzhou University, Zhengzhou, Henan Province, People’s Republic of China, 450001, Email hmmeng2017@zzu.edu.cn Zhaohui Li, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, People’s Republic of China, 450052, Email zhaohui.li@zzu.edu.cn
Purpose: Irinotecan (CPT-11), a semisynthetic camptothecin derivative and topoisomerase I inhibitor, is globally used for treating cancers such as colorectal cancer. However, its clinical application is limited by severe adverse effects, including diarrhea and myelosuppression. Biomimetic nano-drug delivery is widely used and can improve chemotherapeutic activity and decrease side effects.
Methods: In this study, we developed a cancer cell membrane-functionalized metal-organic frameworks for irinotecan/curcumin (named MZCC) for colorectal cancer treatment. In this study, by combining irinotecan, curcumin, MOFs and functionalized cancer cell membrane, a pH-sensitive drug delivery system of MZCC was developed for colorectal cancer treatment with enhanced chemotherapeutic efficacy while reducing side effects. The characteristics and stability of MZCC were carefully examined, and its anti-cancer efficiency was studied in vitro and in vivo. In vivo experiments in a murine colorectal cancer mouse model given intratumorally MZCC injection every 4 days were used to assess antitumor efficacy and systemic toxicity.
Results: The MZCC system improved treatment antitumor efficacy by 2.3-fold compared with free CPT-11 through synergistic chemotherapy. MZCC-treated groups exhibited a significant reduction in inflammatory cytokine levels within colon tissues; inflammation levels decreased by 55% compared with free CPT-11, and colon length was restored to 79% of normal.
Conclusion: Our strategy effectively alleviates CPT-11-induced intestinal toxicity and mitigates adverse reactions. This approach may provide a novel method for enhancing chemotherapeutic efficacy while reducing gastrointestinal toxicity.
Keywords: colorectal cancer, irinotecan, curcumin, metal-organic frameworks, cell membrane