109906
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
妊娠期ITGA2B基因变异所致Glanzmann血小板无力症的围手术期血小板输注策略与多学科协作经验：1例病例报告
Authors Cui X, Ji N , Wang S, Jamal H , Liu J, Wang Y, Sun H
Received 21 June 2025
Accepted for publication 10 November 2025
Published 17 November 2025 Volume 2025:17 Pages 4559—4564
DOI https://doi.org/10.2147/IJWH.S548705
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Matteo Frigerio
Xue Cui,1,* Nuowei Ji,1,* Shengnan Wang,1 Huawei Jamal,2 Jiaxin Liu,1 Ying Wang,3 Haiyan Sun1
1Department of Gynecology and Obstetrics, The Second Hospital of Dalian Medical University, Dalian, Liaoning Province, 116023, People’s Republic of China; 2Nursing Department, Lower Clapton General Practice, London, E5 0RD, UK; 3Department of Laboratory, The Second Hospital of Dalian Medical University, Dalian, Liaoning Province, 116023, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Haiyan Sun, Department of Gynecology and Obstetrics, The Second Hospital of Dalian Medical University, Dalian, Liaoning Province, 116023, People’s Republic of China, Tel +86 411 84671291, Email saya8891@hotmail.com
Objective: To explore multidisciplinary peripartum management strategies and clinical implications for Glanzmann thrombasthenia (GT) caused by ITGA2B gene variation during pregnancy.
Case Presentation: A 33-year-old woman at 38+5weeks of gestation, diagnosed with GT, was confirmed with biallelic pathogenic ITGA2B mutations (chr17:42452041 and chr17:42,457,372). There was no history of consanguineous marriage in the past three generations of her family. Coagulation dysfunction was observed during pregnancy (fibrinogen: 2.69 g/L; thromboelastography (TEG) maximum clot strength: 12 mm). A multidisciplinary team (MDT) recommended preoperative transfusion of 3 therapeutic doses of platelets and 10 units of cryoprecipitate, with dynamic TEG monitoring showing improved clot strength (post-transfusion maximum clot strength: 29.2 mm). A cesarean section delivered a healthy male infant (3455 g, Apgar score 10). Intraoperative bleeding (900 mL) and postoperative incisional oozing were controlled with compression bandages and platelet transfusion. Both mother and infant had favorable outcomes, with the incision achieving Grade II/A healing.
Conclusion: Individualized coagulation regulation, multidisciplinary collaboration, dynamic TEG-guided platelet transfusion, and comprehensive postoperative hemostatic management are critical for GT with pregnancy. This case provides practical insights into peripartum care for GT patients.
Keywords: glanzmann thrombasthenia, pregnancy, ITGA2B gene variation, multidisciplinary collaboration, thromboelastography, TEG
1Department of Gynecology and Obstetrics, The Second Hospital of Dalian Medical University, Dalian, Liaoning Province, 116023, People’s Republic of China; 2Nursing Department, Lower Clapton General Practice, London, E5 0RD, UK; 3Department of Laboratory, The Second Hospital of Dalian Medical University, Dalian, Liaoning Province, 116023, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Haiyan Sun, Department of Gynecology and Obstetrics, The Second Hospital of Dalian Medical University, Dalian, Liaoning Province, 116023, People’s Republic of China, Tel +86 411 84671291, Email saya8891@hotmail.com
Objective: To explore multidisciplinary peripartum management strategies and clinical implications for Glanzmann thrombasthenia (GT) caused by ITGA2B gene variation during pregnancy.
Case Presentation: A 33-year-old woman at 38+5weeks of gestation, diagnosed with GT, was confirmed with biallelic pathogenic ITGA2B mutations (chr17:42452041 and chr17:42,457,372). There was no history of consanguineous marriage in the past three generations of her family. Coagulation dysfunction was observed during pregnancy (fibrinogen: 2.69 g/L; thromboelastography (TEG) maximum clot strength: 12 mm). A multidisciplinary team (MDT) recommended preoperative transfusion of 3 therapeutic doses of platelets and 10 units of cryoprecipitate, with dynamic TEG monitoring showing improved clot strength (post-transfusion maximum clot strength: 29.2 mm). A cesarean section delivered a healthy male infant (3455 g, Apgar score 10). Intraoperative bleeding (900 mL) and postoperative incisional oozing were controlled with compression bandages and platelet transfusion. Both mother and infant had favorable outcomes, with the incision achieving Grade II/A healing.
Conclusion: Individualized coagulation regulation, multidisciplinary collaboration, dynamic TEG-guided platelet transfusion, and comprehensive postoperative hemostatic management are critical for GT with pregnancy. This case provides practical insights into peripartum care for GT patients.
Keywords: glanzmann thrombasthenia, pregnancy, ITGA2B gene variation, multidisciplinary collaboration, thromboelastography, TEG