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已发表论文
阴离子间隙与白蛋白校正阴离子间隙与光敏感性之间的关联：一项全国性的回顾性横断面研究
Received 12 July 2025
Accepted for publication 11 November 2025
Published 17 November 2025 Volume 2025:18 Pages 3075—3086
DOI https://doi.org/10.2147/CCID.S553333
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Monica K. Li
Haoyang Yin, Song Gu
Department of Clinical Medicine, Chinese Medicine Internal Medicine, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, People’s Republic of China
Correspondence: Song Gu, Email songgu03@sohu.com
Background: Sun sensitivity is a significant factor influencing the risk of sunburn and skin cancer. Given that current assessments mainly depend on self-reported information, exploring objective biochemical indicators may provide complementary insights. The purpose of this research was to determine whether anion gap and albumin-corrected anion gap can function as objective and easily accessible biomarkers for sun sensitivity in US adults.
Methods: We conducted a cross-sectional study utilizing data from the National Health and Nutrition Examination Survey collected between 2003– 2006 and 2009– 2018. Weighted logistic regression, restricted cubic splines, and subgroup analyses were conducted to examine the association between AG and ACAG and sun sensitivity.
Results: The analysis was conducted on a total of 17,739 participants. We found a positive correlation between both AG and ACAG with increased sun sensitivity (AG: OR = 1.04, 95% CI = 1.01– 1.07, P = 0.012; ACAG: OR = 1.04, 95% CI = 1.01– 1.07, P = 0.004). It was observed that participants in the highest quartile (Q4) of AG and ACAG presented with heightened sensitivity to sunlight (AG: OR = 1.23, 95% CI = 1.02– 1.50, P = 0.034; ACAG: OR = 1.29, 95% CI = 1.07– 1.57, P = 0.01). Subgroup analyses indicated a consistent trend across various subgroups.
Conclusion: Our study demonstrates that heightened levels of AG and ACAG are related to an elevated degree of sun sensitivity.
Keywords: sun sensitivity, skin protection, AG, ACAG, NHANES, skin photosensitivity
Department of Clinical Medicine, Chinese Medicine Internal Medicine, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, People’s Republic of China
Correspondence: Song Gu, Email songgu03@sohu.com
Background: Sun sensitivity is a significant factor influencing the risk of sunburn and skin cancer. Given that current assessments mainly depend on self-reported information, exploring objective biochemical indicators may provide complementary insights. The purpose of this research was to determine whether anion gap and albumin-corrected anion gap can function as objective and easily accessible biomarkers for sun sensitivity in US adults.
Methods: We conducted a cross-sectional study utilizing data from the National Health and Nutrition Examination Survey collected between 2003– 2006 and 2009– 2018. Weighted logistic regression, restricted cubic splines, and subgroup analyses were conducted to examine the association between AG and ACAG and sun sensitivity.
Results: The analysis was conducted on a total of 17,739 participants. We found a positive correlation between both AG and ACAG with increased sun sensitivity (AG: OR = 1.04, 95% CI = 1.01– 1.07, P = 0.012; ACAG: OR = 1.04, 95% CI = 1.01– 1.07, P = 0.004). It was observed that participants in the highest quartile (Q4) of AG and ACAG presented with heightened sensitivity to sunlight (AG: OR = 1.23, 95% CI = 1.02– 1.50, P = 0.034; ACAG: OR = 1.29, 95% CI = 1.07– 1.57, P = 0.01). Subgroup analyses indicated a consistent trend across various subgroups.
Conclusion: Our study demonstrates that heightened levels of AG and ACAG are related to an elevated degree of sun sensitivity.
Keywords: sun sensitivity, skin protection, AG, ACAG, NHANES, skin photosensitivity