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已发表论文
基于没食子酸修饰氧化石墨烯纳米复合材料的光热-化疗增强黑色素瘤免疫治疗
Authors Feng Y, Jin W, Li Z, Fan G, Zhao J, Zhu M, Wang S, Zhang Y, Li Y, Dong Z
Received 10 April 2025
Accepted for publication 23 October 2025
Published 15 November 2025 Volume 2025:20 Pages 13797—13813
DOI https://doi.org/10.2147/IJN.S531001
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 5
Editor who approved publication: Dr Yan Shen
Yifan Feng,1 Wei Jin,1 Zhuo Li,1 Guangyu Fan,1 Jixiang Zhao,1 Minyu Zhu,1 Siming Wang,2 Yinghua Zhang,3 Ying Li,1,4– 6 Zhengqi Dong1,4– 6
1State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-Di Herbs, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100193, People’s Republic of China; 2Northeast Asian Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin, 130117, People’s Republic of China; 3Department of Traditional Chinese Medicine, Jilin Provincial Academy of Chinese Medicine, Changchun, 130012, People’s Republic of China; 4Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100193, People’s Republic of China; 5Drug Delivery Center, Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Beijing, 100193, People’s Republic of China; 6Department of traditional Chinese medicine, Beijing Key Laboratory of Neuro-Innovative Drug Research and Development of Traditional Chinese Medicine (Natural Medicines), Beijing, 100193, People’s Republic of China
Correspondence: Ying Li, Email yli@implad.ac.cn Zhengqi Dong, Email zqdong@implad.ac.cn
Objective: Conventional therapy for the treatment of melanoma often results in poor therapeutic efficacy, and long-term and systemic administration of cancer chemotherapy is accompanied by unpredictable side effects. Graphene oxide (GO)-based photothermal therapy (PTT) combined with chemotherapy has emerged as a rapid and immunogenic alternative, where near-infrared (NIR) irradiation triggers localized hyperthermia via tumor-targeting photothermal immunomodulatory nanomaterials. However, pristine GO nanosheets tend to aggregate under physiological conditions, compromising their photothermal performance. This study aims to develop a combinatorial regimen integrating GO-enhanced photothermal immunotherapy with chemotherapy for synergistic melanoma treatment.
Methods: We fabricated a novel photothermal nanomaterial through gallic acid(GA) modification of GO (GAGO), with comprehensive characterization including UV-Vis spectroscopy, FTIR, XRD, and TEM to verify successful synthesis. The photothermal conversion efficiency was systematically evaluated, along with an investigation of the combined therapeutic efficacy and underlying mechanisms of GAGO with paclitaxel for melanoma treatment.
Results: In this study, GAGO was developed as a novel photothermal nanomaterial with enhanced dispersibility, superior stability, and reduced biotoxicity, which significantly improved the photothermal conversion efficiency of pristine GO. The synergistic combination of GA-GO-mediated photothermal therapy and paclitaxel chemotherapy effectively activated immune cells and potentiated T cell-mediated antitumor immunity, ultimately achieving remarkable tumor growth suppression.
Conclusion: We construct a synergistic platform of photothermal therapy, immunotherapy and chemotherapy, which provides a promising strategy for effective melanoma treatment.
Keywords: graphene oxide, gallic acid, melanoma, photothermal therapy, immunochemotherapy
1State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-Di Herbs, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100193, People’s Republic of China; 2Northeast Asian Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin, 130117, People’s Republic of China; 3Department of Traditional Chinese Medicine, Jilin Provincial Academy of Chinese Medicine, Changchun, 130012, People’s Republic of China; 4Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100193, People’s Republic of China; 5Drug Delivery Center, Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Beijing, 100193, People’s Republic of China; 6Department of traditional Chinese medicine, Beijing Key Laboratory of Neuro-Innovative Drug Research and Development of Traditional Chinese Medicine (Natural Medicines), Beijing, 100193, People’s Republic of China
Correspondence: Ying Li, Email yli@implad.ac.cn Zhengqi Dong, Email zqdong@implad.ac.cn
Objective: Conventional therapy for the treatment of melanoma often results in poor therapeutic efficacy, and long-term and systemic administration of cancer chemotherapy is accompanied by unpredictable side effects. Graphene oxide (GO)-based photothermal therapy (PTT) combined with chemotherapy has emerged as a rapid and immunogenic alternative, where near-infrared (NIR) irradiation triggers localized hyperthermia via tumor-targeting photothermal immunomodulatory nanomaterials. However, pristine GO nanosheets tend to aggregate under physiological conditions, compromising their photothermal performance. This study aims to develop a combinatorial regimen integrating GO-enhanced photothermal immunotherapy with chemotherapy for synergistic melanoma treatment.
Methods: We fabricated a novel photothermal nanomaterial through gallic acid(GA) modification of GO (GAGO), with comprehensive characterization including UV-Vis spectroscopy, FTIR, XRD, and TEM to verify successful synthesis. The photothermal conversion efficiency was systematically evaluated, along with an investigation of the combined therapeutic efficacy and underlying mechanisms of GAGO with paclitaxel for melanoma treatment.
Results: In this study, GAGO was developed as a novel photothermal nanomaterial with enhanced dispersibility, superior stability, and reduced biotoxicity, which significantly improved the photothermal conversion efficiency of pristine GO. The synergistic combination of GA-GO-mediated photothermal therapy and paclitaxel chemotherapy effectively activated immune cells and potentiated T cell-mediated antitumor immunity, ultimately achieving remarkable tumor growth suppression.
Conclusion: We construct a synergistic platform of photothermal therapy, immunotherapy and chemotherapy, which provides a promising strategy for effective melanoma treatment.
Keywords: graphene oxide, gallic acid, melanoma, photothermal therapy, immunochemotherapy