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已发表论文
巴通体感染合并星座链球菌感染性心内膜炎并发心脏骤停：1 例病例报告及文献复习
Authors Yang Y, Li XJ, Ran CJ, Cheng W, Ma Q, Wang Z , Li Y
Received 6 July 2025
Accepted for publication 21 October 2025
Published 15 November 2025 Volume 2025:18 Pages 5989—5994
DOI https://doi.org/10.2147/IDR.S551897
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Sandip Patil
Yan Yang,1 Xiao-Jin Li,2 Chong-Jun Ran,1 Wei Cheng,3 Qiang Ma,4 Zhen Wang,1 You Li1
1Department of Intensive Care Medicine, Army Medical Center of PLA, Chongqing, People’s Republic of China; 2Department of Neurology, Nanchuan Hospital Affiliated to Chongqing Medical University, Chongqing, People’s Republic of China; 3Department of Ultrasonics Medicine, Army Medical Center of PLA, Chongqing, People’s Republic of China; 4Department of Pathology, Army Medical Center of PLA, Chongqing, People’s Republic of China
Correspondence: You Li, Department of Intensive Care Medicine, Army Medical Center of PLA, No. 10 Changjiang Road, Yuzhong District, Chongqing, 400010, People’s Republic of China, Email dpicuwz@tmmu.edu.cn Zhen Wang, Department of Intensive Care Medicine, Army Medical Center of PLA, No. 10 Changjiang Road, Yuzhong District, Chongqing, 400010, People’s Republic of China, Email reasoncx758@tmmu.edu.cn
Background: Infective endocarditis (IE) is a severe infectious disease affecting the endocardium and cardiac valves, caused by various pathogens. Among numerous pathogenic microorganisms, Staphylococcus aureus is the most common, followed by other streptococci such as Streptococcus viridans and enterococci. Bartonella, a Gram-negative, fastidious parasitic bacillus, is a rare causative agent of IE Streptococcus constellatus, belonging to the Streptococcus milleri group, commonly colonizes oral cavity, upper respiratory tract, and gastrointestinal tract, which can cause infections when host immunity is impaired. This study demonstrates a surviving case of infective endocarditis caused by Streptococcus constellatus, initially illustrating cardiac arrest and Bartonella infection.
Case Presentation: A 59-year-old male with a history of Bartonella infection post-cat scratch presented progressive vision loss and dyspnea. Admitted to the emergency department, he suffered sudden cardiac arrest, necessitating CPR and intubation before transferring to the ICU. Multidisciplinary evaluation confirmed infective endocarditis (IE), and he was implemented a successful valve replacement surgery. Pathogen identification via high-throughput sequencing of valve tissue revealed Streptococcus constellatus. The patient received targeted anti-infective therapy, mechanical ventilation, and cardiopulmonary support, laying solid foundations for successful extubation and transfer for further specialized care.
Conclusion: Bartonella and Streptococcus are rare etiologies of infective endocarditis. This case underscores the vital role of intensive care in managing infective endocarditis resulted from cardiac arrest, as well as the challenges and significance of a multidisciplinary approach to such complex conditions. Furthermore, it highlights the critical utility of high-throughput sequencing in pathogen identification and guiding antimicrobial therapy optimization.
Keywords: cardiac arrest, Bartonella, Streptococcus constellatus, infective endocarditis, high throughput sequencing technology
1Department of Intensive Care Medicine, Army Medical Center of PLA, Chongqing, People’s Republic of China; 2Department of Neurology, Nanchuan Hospital Affiliated to Chongqing Medical University, Chongqing, People’s Republic of China; 3Department of Ultrasonics Medicine, Army Medical Center of PLA, Chongqing, People’s Republic of China; 4Department of Pathology, Army Medical Center of PLA, Chongqing, People’s Republic of China
Correspondence: You Li, Department of Intensive Care Medicine, Army Medical Center of PLA, No. 10 Changjiang Road, Yuzhong District, Chongqing, 400010, People’s Republic of China, Email dpicuwz@tmmu.edu.cn Zhen Wang, Department of Intensive Care Medicine, Army Medical Center of PLA, No. 10 Changjiang Road, Yuzhong District, Chongqing, 400010, People’s Republic of China, Email reasoncx758@tmmu.edu.cn
Background: Infective endocarditis (IE) is a severe infectious disease affecting the endocardium and cardiac valves, caused by various pathogens. Among numerous pathogenic microorganisms, Staphylococcus aureus is the most common, followed by other streptococci such as Streptococcus viridans and enterococci. Bartonella, a Gram-negative, fastidious parasitic bacillus, is a rare causative agent of IE Streptococcus constellatus, belonging to the Streptococcus milleri group, commonly colonizes oral cavity, upper respiratory tract, and gastrointestinal tract, which can cause infections when host immunity is impaired. This study demonstrates a surviving case of infective endocarditis caused by Streptococcus constellatus, initially illustrating cardiac arrest and Bartonella infection.
Case Presentation: A 59-year-old male with a history of Bartonella infection post-cat scratch presented progressive vision loss and dyspnea. Admitted to the emergency department, he suffered sudden cardiac arrest, necessitating CPR and intubation before transferring to the ICU. Multidisciplinary evaluation confirmed infective endocarditis (IE), and he was implemented a successful valve replacement surgery. Pathogen identification via high-throughput sequencing of valve tissue revealed Streptococcus constellatus. The patient received targeted anti-infective therapy, mechanical ventilation, and cardiopulmonary support, laying solid foundations for successful extubation and transfer for further specialized care.
Conclusion: Bartonella and Streptococcus are rare etiologies of infective endocarditis. This case underscores the vital role of intensive care in managing infective endocarditis resulted from cardiac arrest, as well as the challenges and significance of a multidisciplinary approach to such complex conditions. Furthermore, it highlights the critical utility of high-throughput sequencing in pathogen identification and guiding antimicrobial therapy optimization.
Keywords: cardiac arrest, Bartonella, Streptococcus constellatus, infective endocarditis, high throughput sequencing technology