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已发表论文
内源性硫化氢对细菌耐药性的影响
Authors Liu J , Qi Y, Xiao X, Zhang Y
Received 28 June 2025
Accepted for publication 27 October 2025
Published 15 November 2025 Volume 2025:18 Pages 5995—6005
DOI https://doi.org/10.2147/IDR.S550265
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Hazrat Bilal
Jiaqi Liu,1,* Yize Qi,1,* Xiaoguang Xiao,2 Yongli Zhang1
1Department of Critical Care Medicine, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, People’s Republic of China; 2Department of Clinical Laboratory, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yongli Zhang, Email zhangyongli@dmu.edu.cn Xiaoguang Xiao, Email ckxxg@sina.com
Abstract: Infectious diseases, especially sepsis from bacterial infections, significantly threaten global health, with antimicrobial resistance (AMR) complicating treatment and increasing clinical burdens. Antibiotic overuse contributes to AMR by creating selective pressure, reducing the efficacy of traditional therapies, and necessitating new approaches. Endogenous hydrogen sulfide (H2S), a gaseous signaling molecule produced by most bacteria through cystathionine-γ-lyase (CSE), cystathionine-β-synthase (CBS), and 3-mercaptopyruvate sulfurtransferase (3MST), plays a crucial role in bacterial resistance. This review explores the biological functions of bacterial endogenous H2S and its impact on AMR. H2S enhances resistance by neutralizing antibiotic-induced reactive oxygen species (ROS), reducing oxidative stress and DNA damage, and promoting biofilm formation, which obstructs antibiotic penetration and facilitates resistance gene exchange. Furthermore, enhancing H2S-based assays could significantly improve the diagnosis of AMR. Additionally, strategies such as targeting H2S metabolism—through the use of H2S synthase inhibitors or disrupting biofilms via H2S clearance—or the combination of H2S synthase inhibitors with antibiotics, may reverse resistance. A deeper understanding of the mechanisms by which H2S mediates resistance is essential for the development of advanced diagnostic tools and innovative therapies to combat AMR. Its clinical translation may reverse AMR passivity, guide antibiotic sensitizer development, and optimize therapies, holding significant clinical and translational value.
Keywords: endogenous hydrogen sulfide, antibiotic resistance, infectious diseases
1Department of Critical Care Medicine, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, People’s Republic of China; 2Department of Clinical Laboratory, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yongli Zhang, Email zhangyongli@dmu.edu.cn Xiaoguang Xiao, Email ckxxg@sina.com
Abstract: Infectious diseases, especially sepsis from bacterial infections, significantly threaten global health, with antimicrobial resistance (AMR) complicating treatment and increasing clinical burdens. Antibiotic overuse contributes to AMR by creating selective pressure, reducing the efficacy of traditional therapies, and necessitating new approaches. Endogenous hydrogen sulfide (H2S), a gaseous signaling molecule produced by most bacteria through cystathionine-γ-lyase (CSE), cystathionine-β-synthase (CBS), and 3-mercaptopyruvate sulfurtransferase (3MST), plays a crucial role in bacterial resistance. This review explores the biological functions of bacterial endogenous H2S and its impact on AMR. H2S enhances resistance by neutralizing antibiotic-induced reactive oxygen species (ROS), reducing oxidative stress and DNA damage, and promoting biofilm formation, which obstructs antibiotic penetration and facilitates resistance gene exchange. Furthermore, enhancing H2S-based assays could significantly improve the diagnosis of AMR. Additionally, strategies such as targeting H2S metabolism—through the use of H2S synthase inhibitors or disrupting biofilms via H2S clearance—or the combination of H2S synthase inhibitors with antibiotics, may reverse resistance. A deeper understanding of the mechanisms by which H2S mediates resistance is essential for the development of advanced diagnostic tools and innovative therapies to combat AMR. Its clinical translation may reverse AMR passivity, guide antibiotic sensitizer development, and optimize therapies, holding significant clinical and translational value.
Keywords: endogenous hydrogen sulfide, antibiotic resistance, infectious diseases