109906
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
高血压患者及其配偶的疾病感知、健康素养与药物依从性：一种行动者 - 伴侣相互依赖中介模型方法
Authors Han R , Wu C, Qu GS , Chen YC, Zeng XW, Xue QH
Received 30 June 2025
Accepted for publication 4 November 2025
Published 15 November 2025 Volume 2025:19 Pages 3647—3656
DOI https://doi.org/10.2147/PPA.S547453
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Emma Veale
Rui Han,* Chan Wu,* Guang-Su Qu, Ying-Chun Chen, Xiu-Wen Zeng, Qiu-Hua Xue
Department of Cardiovascular Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Qiu-Hua Xue, Department of Cardiovascular Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, People’s Republic of China, Email xueqiuhua0810@163.com
Objective: This study aims to investigate the mediating role of health literacy—both in hypertensive patients and their spouses —on the relationship between illness perception and medication adherence, based on the Actor-Partner Interdependence Mediation Model (APIMeM).
Methods: Hypertensive patients and their spouses from a selected region were recruited through convenience sampling between August 2024 and March 2025. Data were collected using the General Information Questionnaire, Brief Illness Perception Questionnaire, Health Literacy Scale for Chronic Disease Patients, Morisky Medication Adherence Scale, and the Caregiver Self-care Contribution Scale.
Results: (1) Regarding the actor effects, patients’ health literacy partially mediated the relationship between their illness perception and medication adherence (effect size: 0.028, 95% CI: 0.007~0.067, P < 0.05). Similarly, spouses’ health literacy partially mediated the effect of their own illness perception on their medication adherence (effect size: 0.240, 95% CI: 0.165~0.324, P < 0.05). (2) For the partner effects, patients’ health literacy partially mediated the relationship between their spouse’s illness perception and the patient’s medication adherence (effect size: 0.042, 95% CI: 0.018~0.084, P < 0.05). Meanwhile, the spouse’s health literacy fully mediated the effect of the patient’s illness perception on the spouse’s medication adherence (effect size: 0.139, 95% CI: 0.020~0.302, P < 0.05).
Conclusion: A bidirectional actor-partner effect exists between illness perception and medication adherence among hypertensive patients and their spouses. Health literacy plays a significant mediating role in these relationships. These findings suggest that clinical interventions should target both patients and their spouses simultaneously, enhancing health literacy, strengthening disease knowledge, improving illness perception, and thereby promoting better medication adherence.
Keywords: high blood pressure, health literacy, illness perception, medication adherence, actor-partner interdependence model, mediation model
Department of Cardiovascular Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Qiu-Hua Xue, Department of Cardiovascular Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, People’s Republic of China, Email xueqiuhua0810@163.com
Objective: This study aims to investigate the mediating role of health literacy—both in hypertensive patients and their spouses —on the relationship between illness perception and medication adherence, based on the Actor-Partner Interdependence Mediation Model (APIMeM).
Methods: Hypertensive patients and their spouses from a selected region were recruited through convenience sampling between August 2024 and March 2025. Data were collected using the General Information Questionnaire, Brief Illness Perception Questionnaire, Health Literacy Scale for Chronic Disease Patients, Morisky Medication Adherence Scale, and the Caregiver Self-care Contribution Scale.
Results: (1) Regarding the actor effects, patients’ health literacy partially mediated the relationship between their illness perception and medication adherence (effect size: 0.028, 95% CI: 0.007~0.067, P < 0.05). Similarly, spouses’ health literacy partially mediated the effect of their own illness perception on their medication adherence (effect size: 0.240, 95% CI: 0.165~0.324, P < 0.05). (2) For the partner effects, patients’ health literacy partially mediated the relationship between their spouse’s illness perception and the patient’s medication adherence (effect size: 0.042, 95% CI: 0.018~0.084, P < 0.05). Meanwhile, the spouse’s health literacy fully mediated the effect of the patient’s illness perception on the spouse’s medication adherence (effect size: 0.139, 95% CI: 0.020~0.302, P < 0.05).
Conclusion: A bidirectional actor-partner effect exists between illness perception and medication adherence among hypertensive patients and their spouses. Health literacy plays a significant mediating role in these relationships. These findings suggest that clinical interventions should target both patients and their spouses simultaneously, enhancing health literacy, strengthening disease knowledge, improving illness perception, and thereby promoting better medication adherence.
Keywords: high blood pressure, health literacy, illness perception, medication adherence, actor-partner interdependence model, mediation model