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已发表论文
基于信息-动机-行为技能模型的用药素养干预对脑卒中患者用药自我管理能力的影响：一项随机对照试验
Authors Ma L, Liu Z, Chen X, Zhang Q, Chu T, Chen X, Zhang J, Sun R, Wu Y
Received 24 July 2025
Accepted for publication 18 November 2025
Published 27 November 2025 Volume 2025:19 Pages 3785—3805
DOI https://doi.org/10.2147/PPA.S555955
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Ramón Morillo-Verdugo
Linlin Ma,1,2,* Zhimin Liu,3,* Xueru Chen,2 Qian Zhang,2 Tianyu Chu,2 Xian Chen,2 Jiajia Zhang,2 Renjuan Sun,1 Yibo Wu4
1Department of Neurology, Affiliated Hospital of Jiangnan University, Wuxi, People’s Republic of China; 2Wuxi School of Medicine, Jiangnan University, Wuxi, People’s Republic of China; 3Department of Neurology, Binzhou People’s Hospital Affliction to Shandong First Medical University, Binzhou, People’s Republic of China; 4Obstetrics, Gynecology and Reproduction Research Center, Affiliated Hospital of Jiangnan University, Wuxi, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Renjuan Sun, Department of Neurology, Affiliated Hospital of Jiangnan University, Wuxi, People’s Republic of China, Email 15061885987@163.com Yibo Wu, Obstetrics, Gynecology and Reproduction Research Center, Affiliated Hospital of Jiangnan Universit, Wuxi, People’s Republic of China, Email 9862016107@jiangnan.edu.cn
Purpose: This study aimed to evaluate the effectiveness of a multidisciplinary collaborative medication literacy intervention, grounded in the Information-Motivation-Behavioral Skills (IMB) model, on the medication self-management capacity, stroke-related knowledge, medication literacy, medication adherence, and health status of stroke patients.
Patients and Methods: This single-blind, two-arm RCT in a Wuxi tertiary hospital enrolled 127 participants, randomized into intervention (n = 63) and control groups (n = 64). The intervention group received a medication literacy intervention based on the Information-Motivation-Behavioral Skills (IMB) model through multidisciplinary collaboration, while the patients in the control group received standard care and follow-up after discharge. The primary outcome measure was medication self-management capacity, while secondary outcome measures included stroke-related knowledge, medication literacy, medication adherence, blood pressure, lipid levels, and unplanned readmission rates. The generalized estimating equation (GEE) model was employed to assess the effectiveness of the intervention.
Results: Compared with the control group, the intervention group showed significant improvement in medication self-management capacity (βday of discharge = 1.41, p = 0.045, Cohen’s d = 0.31; β4 weeks = 2.74, p = 0.003, Cohen’s d = 0.52; β12 weeks = 3.46, p = 0.003, Cohen’s d = 0.74). Significant improvements were also observed in stroke-related knowledge (β4 weeks = 2.67, p < 0.001; β12 weeks = 3.97, p < 0.001), medication literacy (β4 weeks = 1.22, p < 0.001; β12 weeks = 1.18, p < 0.001), medication compliance (β4 weeks = 1.07, p = 0.034; β12 weeks = 1.45, p = 0.013), and blood pressure reduction (p < 0.05). The intervention did not significantly affect blood lipids or unplanned readmission rates (p > 0.05). The sensitivity analysis using the PP method indicated that the obtained results were comparable to the ITT results, suggesting that the preliminary research results and conclusions of the medication literacy intervention based on multidisciplinary collaboration were reliable.
Conclusion: The medication literacy intervention based on the Information-Motivation-Behavioral Skills (IMB) model effectively enhances the medication self-management capacity of stroke patients. It positively influences several outcomes, including stroke-related knowledge, medication literacy, medication adherence, blood pressure.
Keywords: medication literacy, medication adherence, stroke, intervention studies
1Department of Neurology, Affiliated Hospital of Jiangnan University, Wuxi, People’s Republic of China; 2Wuxi School of Medicine, Jiangnan University, Wuxi, People’s Republic of China; 3Department of Neurology, Binzhou People’s Hospital Affliction to Shandong First Medical University, Binzhou, People’s Republic of China; 4Obstetrics, Gynecology and Reproduction Research Center, Affiliated Hospital of Jiangnan University, Wuxi, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Renjuan Sun, Department of Neurology, Affiliated Hospital of Jiangnan University, Wuxi, People’s Republic of China, Email 15061885987@163.com Yibo Wu, Obstetrics, Gynecology and Reproduction Research Center, Affiliated Hospital of Jiangnan Universit, Wuxi, People’s Republic of China, Email 9862016107@jiangnan.edu.cn
Purpose: This study aimed to evaluate the effectiveness of a multidisciplinary collaborative medication literacy intervention, grounded in the Information-Motivation-Behavioral Skills (IMB) model, on the medication self-management capacity, stroke-related knowledge, medication literacy, medication adherence, and health status of stroke patients.
Patients and Methods: This single-blind, two-arm RCT in a Wuxi tertiary hospital enrolled 127 participants, randomized into intervention (n = 63) and control groups (n = 64). The intervention group received a medication literacy intervention based on the Information-Motivation-Behavioral Skills (IMB) model through multidisciplinary collaboration, while the patients in the control group received standard care and follow-up after discharge. The primary outcome measure was medication self-management capacity, while secondary outcome measures included stroke-related knowledge, medication literacy, medication adherence, blood pressure, lipid levels, and unplanned readmission rates. The generalized estimating equation (GEE) model was employed to assess the effectiveness of the intervention.
Results: Compared with the control group, the intervention group showed significant improvement in medication self-management capacity (βday of discharge = 1.41, p = 0.045, Cohen’s d = 0.31; β4 weeks = 2.74, p = 0.003, Cohen’s d = 0.52; β12 weeks = 3.46, p = 0.003, Cohen’s d = 0.74). Significant improvements were also observed in stroke-related knowledge (β4 weeks = 2.67, p < 0.001; β12 weeks = 3.97, p < 0.001), medication literacy (β4 weeks = 1.22, p < 0.001; β12 weeks = 1.18, p < 0.001), medication compliance (β4 weeks = 1.07, p = 0.034; β12 weeks = 1.45, p = 0.013), and blood pressure reduction (p < 0.05). The intervention did not significantly affect blood lipids or unplanned readmission rates (p > 0.05). The sensitivity analysis using the PP method indicated that the obtained results were comparable to the ITT results, suggesting that the preliminary research results and conclusions of the medication literacy intervention based on multidisciplinary collaboration were reliable.
Conclusion: The medication literacy intervention based on the Information-Motivation-Behavioral Skills (IMB) model effectively enhances the medication self-management capacity of stroke patients. It positively influences several outcomes, including stroke-related knowledge, medication literacy, medication adherence, blood pressure.
Keywords: medication literacy, medication adherence, stroke, intervention studies