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已发表论文
从腹泻粪便样本中分离并鉴定一株新型无色杆菌菌株
Authors Zhang Z, Liu R, Xu H, Li Y
Received 14 September 2025
Accepted for publication 20 November 2025
Published 27 November 2025 Volume 2025:18 Pages 6241—6246
DOI https://doi.org/10.2147/IDR.S567563
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Hazrat Bilal
Zhengliang Zhang,1 Ruishan Liu,2,3 Hao Xu,3 Yaling Li4
1Department of Laboratory Medicine, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China; 2Department of Critical Care Medicine, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China; 3State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China; 4Department of Health Management Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China
Correspondence: Yaling Li, Department of Health Management Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China, Tel /Fax +86-571-87784688, Email liyaling95@zju.edu.cn
Abstract: A novel bacterial strain, designated as L3024hy, was isolated from the fecal matter of a patient suffering from diarrhea in China. Whole-genome sequencing has identified this strain as a member of the genus Achromobacter. Comparative genomic analyses, including Average Nucleotide Identity (ANI) and digital DNA–DNA hybridization (dDDH), indicated that L3024hy constitutes a distinct lineage within this genus, as evidenced by ANI and dDDH values falling below established thresholds for species demarcation. This strain harbors multiple virulence genes associated with host colonization, suggesting its potential clinical significance. This study underscores the increasing diversity of the genus Achromobacter and emphasizes the necessity for further research on its role in human infections.
Keywords: whole-genome sequencing, average nucleotide identity, digital DNA-DNA hybridization, virulence-associated genes
1Department of Laboratory Medicine, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China; 2Department of Critical Care Medicine, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China; 3State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China; 4Department of Health Management Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China
Correspondence: Yaling Li, Department of Health Management Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China, Tel /Fax +86-571-87784688, Email liyaling95@zju.edu.cn
Abstract: A novel bacterial strain, designated as L3024hy, was isolated from the fecal matter of a patient suffering from diarrhea in China. Whole-genome sequencing has identified this strain as a member of the genus Achromobacter. Comparative genomic analyses, including Average Nucleotide Identity (ANI) and digital DNA–DNA hybridization (dDDH), indicated that L3024hy constitutes a distinct lineage within this genus, as evidenced by ANI and dDDH values falling below established thresholds for species demarcation. This strain harbors multiple virulence genes associated with host colonization, suggesting its potential clinical significance. This study underscores the increasing diversity of the genus Achromobacter and emphasizes the necessity for further research on its role in human infections.
Keywords: whole-genome sequencing, average nucleotide identity, digital DNA-DNA hybridization, virulence-associated genes