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已发表论文
血清尿酸与非多囊卵巢综合征女性宫腔内人工授精结局：一项回顾性研究
Authors Zhang X, Dong Y , Sun R, Yang H, Yu L, Wang D, Chang R, Wei X, Wang S, Chen F, Qin Q
Received 11 July 2025
Accepted for publication 6 November 2025
Published 27 November 2025 Volume 2025:17 Pages 4995—5005
DOI https://doi.org/10.2147/IJWH.S552998
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Everett Magann
Xiaohui Zhang,1,* Yehao Dong,1,* Ronghao Sun,2 Haochen Yang,2 Lu Yu,2 Dan Wang,2 Runze Chang,2 Xinyang Wei,2 Shilei Wang,2 Fei Chen,2 Qianqian Qin1
1Center for Reproductive Medicine, Affiliated Hospital of Jining Medical University, Jining, People’s Republic of China; 2Department of Physiology, Jining Medical University, Jining, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Qianqian Qin, Center for Reproductive Medicine, Affiliated Hospital of Jining Medical University, No. 89, Guhuai Road, Jining City, Shandong Province, 272029, People’s Republic of China, Tel/Fax +86 05372610652, Email jyfyqqq@163.com Fei Chen, Department of Physiology, Jining Medical University, No. 133, Hehua Road, Jining City, Shandong Province, 272067, People’s Republic of China, Tel/Fax +86 05372610652, Email chenfei123@mail.jnmc.edu.cn
Purpose: To investigate the association between serum uric acid (SUA) levels and reproductive outcomes in non-polycystic ovary syndrome (PCOS) women undergoing intrauterine insemination (IUI) treatment.
Patients and Methods: This retrospective study examined 2448 IUI cycles at a large reproductive health center from 2015 to 2024. They were categorized into four groups according to SUA quartiles. Differences in pregnancy and obstetric outcomes of women without PCOS were compared among these groups. Logistic regression analysis was applied to obtain the odds ratio (OR) and 95% confidence interval (CI) for outcomes with or without adjusting for confounding variables.
Results: There was no significant difference in the biochemical pregnancy rate from the lowest SUA quartile (Q1: 18.81%) to the highest (Q4: 17.81%) (adjusted OR 0.80, 95% CI: 0.58– 1.09, P=0.455). Similarly, both the unadjusted and adjusted models indicated that SUA level had no significant effect on most reproductive outcomes including clinical pregnancy rate, miscarriage rate, and live birth rate (P> 0.05). Notably, mean birth weight in Q3 (3376.93 ± 64.63 g) was the highest among the four groups (P=0.021). Consistent with this result, the low birth weight rate in Q3 was significantly lower than in Q1 in Model 3 (adjusted OR 0.21, 95% CI: 0.05– 0.94, P=0.041) after adjusting for factors such as age, body mass index, menstrual cycle, and systolic blood pressure.
Conclusion: We conclude that pre-pregnancy SUA does not impair reproductive outcomes in women without PCOS undergoing IUI treatment. Fetal growth and subsequent birth weight would appear to benefit from an appropriate maternal SUA level. However, the precise efficacy and mechanism of action need to be further investigated.
Keywords: uric acid, intrauterine insemination, infertility, sex hormones, pregnancy rate, reproductive outcomes
1Center for Reproductive Medicine, Affiliated Hospital of Jining Medical University, Jining, People’s Republic of China; 2Department of Physiology, Jining Medical University, Jining, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Qianqian Qin, Center for Reproductive Medicine, Affiliated Hospital of Jining Medical University, No. 89, Guhuai Road, Jining City, Shandong Province, 272029, People’s Republic of China, Tel/Fax +86 05372610652, Email jyfyqqq@163.com Fei Chen, Department of Physiology, Jining Medical University, No. 133, Hehua Road, Jining City, Shandong Province, 272067, People’s Republic of China, Tel/Fax +86 05372610652, Email chenfei123@mail.jnmc.edu.cn
Purpose: To investigate the association between serum uric acid (SUA) levels and reproductive outcomes in non-polycystic ovary syndrome (PCOS) women undergoing intrauterine insemination (IUI) treatment.
Patients and Methods: This retrospective study examined 2448 IUI cycles at a large reproductive health center from 2015 to 2024. They were categorized into four groups according to SUA quartiles. Differences in pregnancy and obstetric outcomes of women without PCOS were compared among these groups. Logistic regression analysis was applied to obtain the odds ratio (OR) and 95% confidence interval (CI) for outcomes with or without adjusting for confounding variables.
Results: There was no significant difference in the biochemical pregnancy rate from the lowest SUA quartile (Q1: 18.81%) to the highest (Q4: 17.81%) (adjusted OR 0.80, 95% CI: 0.58– 1.09, P=0.455). Similarly, both the unadjusted and adjusted models indicated that SUA level had no significant effect on most reproductive outcomes including clinical pregnancy rate, miscarriage rate, and live birth rate (P> 0.05). Notably, mean birth weight in Q3 (3376.93 ± 64.63 g) was the highest among the four groups (P=0.021). Consistent with this result, the low birth weight rate in Q3 was significantly lower than in Q1 in Model 3 (adjusted OR 0.21, 95% CI: 0.05– 0.94, P=0.041) after adjusting for factors such as age, body mass index, menstrual cycle, and systolic blood pressure.
Conclusion: We conclude that pre-pregnancy SUA does not impair reproductive outcomes in women without PCOS undergoing IUI treatment. Fetal growth and subsequent birth weight would appear to benefit from an appropriate maternal SUA level. However, the precise efficacy and mechanism of action need to be further investigated.
Keywords: uric acid, intrauterine insemination, infertility, sex hormones, pregnancy rate, reproductive outcomes