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已发表论文
推进痛风性关节炎研究：全血细胞计数比值及免疫炎症相互作用的临床价值
Authors Gao L , Liu C, Ye G , Gao Y, Wang H
Received 29 July 2025
Accepted for publication 16 November 2025
Published 26 November 2025 Volume 2025:18 Pages 16597—16610
DOI https://doi.org/10.2147/JIR.S556837
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Prof. Dr. Yan Chen
Luyuan Gao,* Chunping Liu,* Guancheng Ye,* Yingkai Gao, Hailong Wang
Department of Rheumatology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Hailong Wang, Department of Rheumatology, Dongzhimen Hospital, Beijing University of Chinese Medicine, No. 116, Cuiping West Street, Beijing, 101121, People’s Republic of China, Email wanghailong@bucm.edu.cn
Abstract: Gouty arthritis (GA) is an inflammatory condition resulting from the accumulation of monosodium urate (MSU) crystals in joints and adjacent tissues, with its pathogenesis characterized by a complex immune-inflammatory response. The complete blood cell count ratios (CBCRs), which include the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammatory index (SII), and systemic inflammatory response index (SIRI), serve as composite indicators of inflammation. These ratios integrate hematopoietic cell subsets that reflect interactions between innate and adaptive immunity, thereby providing a more comprehensive assessment of the intricate immune-inflammatory network in GA. Additionally, they offer practical benefits due to their accessibility in routine clinical settings. This narrative review consolidates the current research on CBCRs in the context of GA, offering an overview of their clinical significance and potential molecular pathological mechanisms. The aim is to provide new insights and evidence-based references for both clinical practice and translational research.
Keywords: gouty arthritis, biomarkers, neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, immune-inflammatory response
Department of Rheumatology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Hailong Wang, Department of Rheumatology, Dongzhimen Hospital, Beijing University of Chinese Medicine, No. 116, Cuiping West Street, Beijing, 101121, People’s Republic of China, Email wanghailong@bucm.edu.cn
Abstract: Gouty arthritis (GA) is an inflammatory condition resulting from the accumulation of monosodium urate (MSU) crystals in joints and adjacent tissues, with its pathogenesis characterized by a complex immune-inflammatory response. The complete blood cell count ratios (CBCRs), which include the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammatory index (SII), and systemic inflammatory response index (SIRI), serve as composite indicators of inflammation. These ratios integrate hematopoietic cell subsets that reflect interactions between innate and adaptive immunity, thereby providing a more comprehensive assessment of the intricate immune-inflammatory network in GA. Additionally, they offer practical benefits due to their accessibility in routine clinical settings. This narrative review consolidates the current research on CBCRs in the context of GA, offering an overview of their clinical significance and potential molecular pathological mechanisms. The aim is to provide new insights and evidence-based references for both clinical practice and translational research.
Keywords: gouty arthritis, biomarkers, neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, immune-inflammatory response