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已发表论文
经皮电针刺激对接受经皮内镜腰椎间盘切除术患者术后疼痛控制及活动能力的影响：一项前瞻性随机试验的研究方案
Authors Hu CF, Meng FX, Luo X , Chen BY
Received 6 August 2025
Accepted for publication 18 November 2025
Published 26 November 2025 Volume 2025:18 Pages 6345—6357
DOI https://doi.org/10.2147/JPR.S554528
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Jinlei Li
Chen-Fu Hu,1 Fan-Xing Meng,1 Xin Luo,2,* Bing-Yao Chen1,*
1Department of Orthopedics, Beijing Daxing District People’s Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xin Luo, Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China, Email tilamisu19893@sina.com Bing-Yao Chen, Department of Orthopedics, Beijing Daxing District People’s Hospital, Capital Medical University, Beijing, People’s Republic of China, Email dxgk123@163.com
Purpose: Optimal perioperative analgesia and early ambulation are critical protocols of enhanced recovery after surgery (ERAS), which significantly impact patients’ clinical outcomes in spine surgery. Transcutaneous electrical acupoint stimulation (TEAS), a well-integrated technique combining the meridian-based protocols of conventional needle acupuncture with noninvasive modern electrotherapy, has been widely used to enhance perioperative recovery. Although several studies have confirmed the safety and feasibility of TEAS in various spinal procedures, clinical evidence supporting its application in percutaneous endoscopic lumbar discectomy (PELD) remains limited, prompting surgeons to evaluate its role within spine ERAS protocols. We hypothesized that, compared with placebo acupuncture, TEAS would provide superior pain relief and reduce analgesic requirements during the perioperative period, thereby decreasing opioid-related side effects, facilitating earlier ambulation, and improving short-term postoperative recovery quality after PELD.
Methods: This prospective, single-blind, randomized controlled clinical trial will enroll 86 patients scheduled to undergo PELD. Participants will be randomly assigned (1:1) to an active TEAS group (Group A) or a placebo TEAS group (Group P). In Group A, TEAS is applied bilaterally at Neiguan (PC6), Chengshan (BL57), Sanyinjiao (SP6), and Dachangshu (BL25) using alternating frequencies of 2/100 Hz and intensity ranging from 10 to 15 mA, adjusted to each patient’s maximum tolerable level. In Group P, electrodes are placed bilaterally at four non-acupoint sites (located 7 cun and 9 cun above and 1 cun outside HT7, and at 9 cun and 12 cun above BL60) and connected to the stimulator without activating electrical output, maintaining participant blinding. The treatment period includes 30 minutes prior to surgery, continuous stimulation throughout the procedure on the surgery day, and 30-minute interventions each morning on postoperative days 1 and 2 followed by 6 months of follow-up. The primary endpoint is time to postoperative ambulation. Secondary outcomes include pain-related indicators, scores on the 15-item Quality of Recovery scale (QoR-15), gastrointestinal function restoration, adverse events, patient satisfaction, and exploratory assessment of spinal function recovery indicators.
Discussion: TEAS offers an alternative for optimal perioperative pain management and promotion of early ambulation, congruent with alleviated ERAS protocols for endoscopic spine surgery.
Conclusion: This study aims to verify whether TEAS will benefit future patients and contribute to meaningful improvements in ERAS-based perioperative management for micro-spine surgery, ultimately supporting the establishment of a standardized PELD day-surgery model.
Trial Registration: The International Traditional Medicine Clinical Trial Registry (http://itmctr.ccebtcm.org.cn/); registered on April 17, 2025. Trial Registration Number: ITMCTR2025000779.
Plain Language Summary: Lumbar spine conditions like herniated discs and spinal narrowing are becoming more common, especially in middle-aged and older adults. These conditions often cause pain and limit mobility. Surgeons increasingly use a minimally invasive procedure called percutaneous endoscopic lumbar discectomy (PELD) to treat these problems. PELD allows for faster recovery, less tissue damage, and shorter hospital stays.
In this study, our research team explored whether a noninvasive therapy called transcutaneous electrical acupoint stimulation (TEAS) could influence postoperative recovery after PELD. TEAS works by sending mild electrical pulses to specific points on the skin, similar to acupuncture but without needles. Previous studies have shown that TEAS may have possible benefits in reducing perioperative adverse events.
We plan to enroll 86 patients undergoing PELD and randomly assign them to receive either real TEAS or a placebo version. Both groups will receive standard anesthesia and pain management. The study will assess postoperative recovery by measuring the time to first ambulation, pain levels, and the need for additional pain medications. The findings of this trial may provide clinical evidence on the feasibility and potential role of TEAS within perioperative ERAS management for PELD.
Keywords: percutaneous endoscopic lumbar discectomy, transcutaneous electrical acupoint stimulation, early ambulation time, perioperative pain, postoperative recovery
1Department of Orthopedics, Beijing Daxing District People’s Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xin Luo, Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China, Email tilamisu19893@sina.com Bing-Yao Chen, Department of Orthopedics, Beijing Daxing District People’s Hospital, Capital Medical University, Beijing, People’s Republic of China, Email dxgk123@163.com
Purpose: Optimal perioperative analgesia and early ambulation are critical protocols of enhanced recovery after surgery (ERAS), which significantly impact patients’ clinical outcomes in spine surgery. Transcutaneous electrical acupoint stimulation (TEAS), a well-integrated technique combining the meridian-based protocols of conventional needle acupuncture with noninvasive modern electrotherapy, has been widely used to enhance perioperative recovery. Although several studies have confirmed the safety and feasibility of TEAS in various spinal procedures, clinical evidence supporting its application in percutaneous endoscopic lumbar discectomy (PELD) remains limited, prompting surgeons to evaluate its role within spine ERAS protocols. We hypothesized that, compared with placebo acupuncture, TEAS would provide superior pain relief and reduce analgesic requirements during the perioperative period, thereby decreasing opioid-related side effects, facilitating earlier ambulation, and improving short-term postoperative recovery quality after PELD.
Methods: This prospective, single-blind, randomized controlled clinical trial will enroll 86 patients scheduled to undergo PELD. Participants will be randomly assigned (1:1) to an active TEAS group (Group A) or a placebo TEAS group (Group P). In Group A, TEAS is applied bilaterally at Neiguan (PC6), Chengshan (BL57), Sanyinjiao (SP6), and Dachangshu (BL25) using alternating frequencies of 2/100 Hz and intensity ranging from 10 to 15 mA, adjusted to each patient’s maximum tolerable level. In Group P, electrodes are placed bilaterally at four non-acupoint sites (located 7 cun and 9 cun above and 1 cun outside HT7, and at 9 cun and 12 cun above BL60) and connected to the stimulator without activating electrical output, maintaining participant blinding. The treatment period includes 30 minutes prior to surgery, continuous stimulation throughout the procedure on the surgery day, and 30-minute interventions each morning on postoperative days 1 and 2 followed by 6 months of follow-up. The primary endpoint is time to postoperative ambulation. Secondary outcomes include pain-related indicators, scores on the 15-item Quality of Recovery scale (QoR-15), gastrointestinal function restoration, adverse events, patient satisfaction, and exploratory assessment of spinal function recovery indicators.
Discussion: TEAS offers an alternative for optimal perioperative pain management and promotion of early ambulation, congruent with alleviated ERAS protocols for endoscopic spine surgery.
Conclusion: This study aims to verify whether TEAS will benefit future patients and contribute to meaningful improvements in ERAS-based perioperative management for micro-spine surgery, ultimately supporting the establishment of a standardized PELD day-surgery model.
Trial Registration: The International Traditional Medicine Clinical Trial Registry (http://itmctr.ccebtcm.org.cn/); registered on April 17, 2025. Trial Registration Number: ITMCTR2025000779.
Plain Language Summary: Lumbar spine conditions like herniated discs and spinal narrowing are becoming more common, especially in middle-aged and older adults. These conditions often cause pain and limit mobility. Surgeons increasingly use a minimally invasive procedure called percutaneous endoscopic lumbar discectomy (PELD) to treat these problems. PELD allows for faster recovery, less tissue damage, and shorter hospital stays.
In this study, our research team explored whether a noninvasive therapy called transcutaneous electrical acupoint stimulation (TEAS) could influence postoperative recovery after PELD. TEAS works by sending mild electrical pulses to specific points on the skin, similar to acupuncture but without needles. Previous studies have shown that TEAS may have possible benefits in reducing perioperative adverse events.
We plan to enroll 86 patients undergoing PELD and randomly assign them to receive either real TEAS or a placebo version. Both groups will receive standard anesthesia and pain management. The study will assess postoperative recovery by measuring the time to first ambulation, pain levels, and the need for additional pain medications. The findings of this trial may provide clinical evidence on the feasibility and potential role of TEAS within perioperative ERAS management for PELD.
Keywords: percutaneous endoscopic lumbar discectomy, transcutaneous electrical acupoint stimulation, early ambulation time, perioperative pain, postoperative recovery