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已发表论文
将细胞衰老与血管病理学联系起来：超氧化物歧化酶 2 在主动脉夹层中的诊断潜力
Authors Wu X, Qin J, Tang D, Wang X, Wang R, Li W, Zhang J, Lu X
Received 14 July 2025
Accepted for publication 14 October 2025
Published 26 November 2025 Volume 2025:21 Pages 983—1005
DOI https://doi.org/10.2147/VHRM.S553609
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Daniel Duprez
Xiaoyu Wu,1,* Jinbao Qin,1,* Dianjun Tang,2 Xin Wang,1 Ruihua Wang,1 Weimin Li,1 Jian Zhang,3 Xinwu Lu1
1Department of Vascular Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, People’s Republic of China; 2Department of Vascular Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250030 People’s Republic of China; 3Department of Vascular Surgery, The First Hospital of China Medical University, Shenyang, Liaoning, 110001, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xinwu Lu, Department of Vascular Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, People’s Republic of China, Email luxinwu@shsmu.edu.cn Jian Zhang, Department of Vascular Surgery, The First Hospital of China Medical University, Shenyang, Liaoning, 110001, People’s Republic of China, Email jianzhang@cmu.edu.cn
Introduction: This study investigates the molecular and cellular mechanisms of vascular aging and its critical role in the pathogenesis of aortic dissection (AD), employing an integrative approach that includes bioinformatics and single-cell transcriptomic analyses.
Methods: Differentially expressed genes (DEGs) were identified from publicly available datasets (GSE52093, GSE153434), with 194 upregulated and 518 downregulated genes, 16 of which were associated with vascular aging. Superoxide dismutase 2 (SOD2) was identified as a critical gene, demonstrating significant diagnostic accuracy for AD through ROC analysis. Single-cell RNA sequencing of AD tissues revealed cellular heterogeneity, with a predominant macrophage infiltration and altered proportions of endothelial and smooth muscle cells.
Results: SOD2 was notably expressed in macrophages and dendritic cells, particularly in AD tissues, suggesting its involvement in immune modulation. Validation of SOD2 at both mRNA and protein levels showed elevated expression in AD tissues and serum, correlating with increased oxidative stress and immune cell infiltration. Elevated serum SOD2 levels were linked to poor clinical outcomes, particularly higher in-hospital mortality. Immune profiling further identified significant associations between SOD2 and macrophage activity.
Conclusion: These findings suggest SOD2 as a potential diagnostic biomarker and therapeutic target for AD. A gene-drug interaction network proposed pharmacological candidates for SOD2 modulation, paving the way for targeted therapies. This study advances the understanding of AD pathogenesis, emphasizing the interplay between oxidative stress, immune response, and vascular aging at both molecular and cellular levels.
Keywords: aortic dissection, SOD2, superoxide dismutase 2, single-cell RNA sequencing, bioinformatics analysis, gene-drug interaction network
1Department of Vascular Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, People’s Republic of China; 2Department of Vascular Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250030 People’s Republic of China; 3Department of Vascular Surgery, The First Hospital of China Medical University, Shenyang, Liaoning, 110001, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xinwu Lu, Department of Vascular Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, People’s Republic of China, Email luxinwu@shsmu.edu.cn Jian Zhang, Department of Vascular Surgery, The First Hospital of China Medical University, Shenyang, Liaoning, 110001, People’s Republic of China, Email jianzhang@cmu.edu.cn
Introduction: This study investigates the molecular and cellular mechanisms of vascular aging and its critical role in the pathogenesis of aortic dissection (AD), employing an integrative approach that includes bioinformatics and single-cell transcriptomic analyses.
Methods: Differentially expressed genes (DEGs) were identified from publicly available datasets (GSE52093, GSE153434), with 194 upregulated and 518 downregulated genes, 16 of which were associated with vascular aging. Superoxide dismutase 2 (SOD2) was identified as a critical gene, demonstrating significant diagnostic accuracy for AD through ROC analysis. Single-cell RNA sequencing of AD tissues revealed cellular heterogeneity, with a predominant macrophage infiltration and altered proportions of endothelial and smooth muscle cells.
Results: SOD2 was notably expressed in macrophages and dendritic cells, particularly in AD tissues, suggesting its involvement in immune modulation. Validation of SOD2 at both mRNA and protein levels showed elevated expression in AD tissues and serum, correlating with increased oxidative stress and immune cell infiltration. Elevated serum SOD2 levels were linked to poor clinical outcomes, particularly higher in-hospital mortality. Immune profiling further identified significant associations between SOD2 and macrophage activity.
Conclusion: These findings suggest SOD2 as a potential diagnostic biomarker and therapeutic target for AD. A gene-drug interaction network proposed pharmacological candidates for SOD2 modulation, paving the way for targeted therapies. This study advances the understanding of AD pathogenesis, emphasizing the interplay between oxidative stress, immune response, and vascular aging at both molecular and cellular levels.
Keywords: aortic dissection, SOD2, superoxide dismutase 2, single-cell RNA sequencing, bioinformatics analysis, gene-drug interaction network