111614
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
电针治疗腰椎间盘突出症亚急性期：一项结合脑电图的随机对照试验方案
Authors Yu H, Zhang J, Zhang D, Zhao L, Wu S, Zhang L, Yang Y, Li G
Received 2 August 2025
Accepted for publication 6 November 2025
Published 26 November 2025 Volume 2025:18 Pages 6279—6295
DOI https://doi.org/10.2147/JPR.S557800
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Houman Danesh
Hanbo Yu,* Jie Zhang,* Dingchen Zhang, Lingyan Zhao, Sixian Wu, Luofan Zhang, Youlie Yang, Guiping Li
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Guiping Li, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, People’s Republic of China, Email lily_doc@sina.com
Purpose: This study aims to elucidate the central mechanisms of electroacupuncture (EA) for subacute lumbar disc herniation (LDH) using electroencephalography (EEG). To our knowledge, this is the first study to apply EEG to characterize the neurophysiological correlates of EA treatment in this specific clinical condition.
Patients and Methods: In this randomized controlled trial, a total of 66 patients with subacute lumbar disc herniation (LDH) will be enrolled from the Departments of Acupuncture and Orthopedics. Participants will be randomly allocated at a 1:1 ratio to either an EA group or a sham EA group, resulting in 33 participants per group. The primary outcomes are the clinical efficacy rate and the Japanese Orthopaedic Association (JOA) score. Secondary outcomes include the Oswestry Disability Index (ODI) and the Visual Analogue Scale (VAS) for pain. Clinical outcomes will be assessed at baseline, two weeks, four weeks (end of treatment), and at a three-month follow-up. The neuroimaging outcome is EEG. EEG data will be collected at baseline and at the four-week endpoint, with analyses focusing on core parameters such as power spectral density (PSD) analysis, time-frequency analysis, and microstate analysis.
Conclusion: This study will verify the clinical efficacy of electroacupuncture in treating subacute LDH and explore its core central mechanisms using EEG technology. We anticipate that the expected improvements in clinical outcomes (eg, JOA, ODI, and VAS scores) will significantly correlate with the normalization of aberrant neural oscillations—specifically, a reduction in theta power and restoration of alpha activity. Such findings would provide direct neuroimaging evidence for EA’s central neuromodulatory role, offering a mechanistic basis for its broader clinical application in the treatment of LDH.
Keywords: lumbar disc herniation, electroacupuncture, electroencephalography, protocol
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Guiping Li, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, People’s Republic of China, Email lily_doc@sina.com
Purpose: This study aims to elucidate the central mechanisms of electroacupuncture (EA) for subacute lumbar disc herniation (LDH) using electroencephalography (EEG). To our knowledge, this is the first study to apply EEG to characterize the neurophysiological correlates of EA treatment in this specific clinical condition.
Patients and Methods: In this randomized controlled trial, a total of 66 patients with subacute lumbar disc herniation (LDH) will be enrolled from the Departments of Acupuncture and Orthopedics. Participants will be randomly allocated at a 1:1 ratio to either an EA group or a sham EA group, resulting in 33 participants per group. The primary outcomes are the clinical efficacy rate and the Japanese Orthopaedic Association (JOA) score. Secondary outcomes include the Oswestry Disability Index (ODI) and the Visual Analogue Scale (VAS) for pain. Clinical outcomes will be assessed at baseline, two weeks, four weeks (end of treatment), and at a three-month follow-up. The neuroimaging outcome is EEG. EEG data will be collected at baseline and at the four-week endpoint, with analyses focusing on core parameters such as power spectral density (PSD) analysis, time-frequency analysis, and microstate analysis.
Conclusion: This study will verify the clinical efficacy of electroacupuncture in treating subacute LDH and explore its core central mechanisms using EEG technology. We anticipate that the expected improvements in clinical outcomes (eg, JOA, ODI, and VAS scores) will significantly correlate with the normalization of aberrant neural oscillations—specifically, a reduction in theta power and restoration of alpha activity. Such findings would provide direct neuroimaging evidence for EA’s central neuromodulatory role, offering a mechanistic basis for its broader clinical application in the treatment of LDH.
Keywords: lumbar disc herniation, electroacupuncture, electroencephalography, protocol