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已发表论文
坏死性筋膜炎动物模型的研究进展：当前趋势与未来展望
Authors Li J , Huang C, Huang W, Zhou X, Wu Y, Li Y, Yang X
Received 24 July 2025
Accepted for publication 16 November 2025
Published 26 November 2025 Volume 2025:18 Pages 16473—16486
DOI https://doi.org/10.2147/JIR.S555959
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Xin Du
Jun Li,1,2,* Chengzi Huang,1,2,* Weizheng Huang,2,3,* Xin Zhou,2,3 Yujiao Wu,2,3 Yaling Li,4 Xiangdong Yang1,5
1Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of China; 2Department of Anorectal, The Affiliated Hospital, Southwest Medical University, Luzhou, People’s Republic of China; 3College of Integrated Traditional Chinese and Western Medicine, Southwest Medical University, Luzhou, People’s Republic of China; 4Department of Pharmacy, The Affiliated Hospital, Southwest Medical University, Luzhou, People’s Republic of China; 5Chengdu Anorectal Hospital, Chengdu, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yaling Li, The Affiliated Hospital, Southwest Medical University, No. 25 Taiping Street, Jiangyang District, Luzhou, Sichuan, People’s Republic of China, Email lylapothecary@swmu.edu.cn Xiangdong Yang, Chengdu Anorectal Hospital, No. 152, Daqiang East Street, Taisheng South Road, Qingyang District, Chengdu, People’s Republic of China, Email y-xd@vip.163.com
Abstract: Necrotizing fasciitis (NF) is a rapidly progressive soft tissue infection with high morbidity and mortality, yet its pathophysiology remains incompletely understood. Animal models are indispensable for dissecting disease mechanisms and testing therapeutic interventions, yet their translational relevance varies across species and experimental approaches. This review critically evaluates NF models in rodents, zebrafish, rabbits, pigs, and non-human primates, highlighting their relative strengths in replicating immunopathology, systemic dissemination, and biofilm-driven persistence. We examine methodological strategies including bacterial inoculation, trauma-induced infection, immunosuppression-enhanced infection, genetic engineering, and optical imaging, and discuss how these frameworks capture discrete aspects of NF pathogenesis. Emerging technologies, including CRISPR-mediated host factor engineering, multi-omics profiling, intravital and high-resolution imaging, organ-on-chip platforms, and artificial intelligence, are integrated into next-generation models to enhance predictive power, mechanistic insight, and translational fidelity. We also outline innovative therapeutic strategies validated in preclinical models, from precision-targeted monoclonal antibodies and immunotherapies to advanced drug delivery systems and AI-guided predictive modeling. Finally, we discuss practical and ethical considerations for NF modeling, emphasizing reproducibility, standardization, and the 3Rs principle, and propose a forward-looking framework for integrating in vivo, in vitro, and in silico platforms. Collectively, these insights provide a roadmap for refining NF animal models, accelerating mechanistic discovery, and informing clinically relevant interventions.
Keywords: fasciitis, necrotizing, disease models, animal, coinfection, precision therapeutics, translational medical research
1Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of China; 2Department of Anorectal, The Affiliated Hospital, Southwest Medical University, Luzhou, People’s Republic of China; 3College of Integrated Traditional Chinese and Western Medicine, Southwest Medical University, Luzhou, People’s Republic of China; 4Department of Pharmacy, The Affiliated Hospital, Southwest Medical University, Luzhou, People’s Republic of China; 5Chengdu Anorectal Hospital, Chengdu, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yaling Li, The Affiliated Hospital, Southwest Medical University, No. 25 Taiping Street, Jiangyang District, Luzhou, Sichuan, People’s Republic of China, Email lylapothecary@swmu.edu.cn Xiangdong Yang, Chengdu Anorectal Hospital, No. 152, Daqiang East Street, Taisheng South Road, Qingyang District, Chengdu, People’s Republic of China, Email y-xd@vip.163.com
Abstract: Necrotizing fasciitis (NF) is a rapidly progressive soft tissue infection with high morbidity and mortality, yet its pathophysiology remains incompletely understood. Animal models are indispensable for dissecting disease mechanisms and testing therapeutic interventions, yet their translational relevance varies across species and experimental approaches. This review critically evaluates NF models in rodents, zebrafish, rabbits, pigs, and non-human primates, highlighting their relative strengths in replicating immunopathology, systemic dissemination, and biofilm-driven persistence. We examine methodological strategies including bacterial inoculation, trauma-induced infection, immunosuppression-enhanced infection, genetic engineering, and optical imaging, and discuss how these frameworks capture discrete aspects of NF pathogenesis. Emerging technologies, including CRISPR-mediated host factor engineering, multi-omics profiling, intravital and high-resolution imaging, organ-on-chip platforms, and artificial intelligence, are integrated into next-generation models to enhance predictive power, mechanistic insight, and translational fidelity. We also outline innovative therapeutic strategies validated in preclinical models, from precision-targeted monoclonal antibodies and immunotherapies to advanced drug delivery systems and AI-guided predictive modeling. Finally, we discuss practical and ethical considerations for NF modeling, emphasizing reproducibility, standardization, and the 3Rs principle, and propose a forward-looking framework for integrating in vivo, in vitro, and in silico platforms. Collectively, these insights provide a roadmap for refining NF animal models, accelerating mechanistic discovery, and informing clinically relevant interventions.
Keywords: fasciitis, necrotizing, disease models, animal, coinfection, precision therapeutics, translational medical research