111614
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
正常肺功能测定者中 FEV3/FVC 降低作为慢性阻塞性肺疾病早期指标的前瞻性分析：来自 ECOPD 研究的数据
Authors Li Y , Li J, Huang S , Wu F , Deng Z, Peng J, Zhou K, Tang G, Wan Q, Dai C , Lu L , Wu X, Zeng X, Wu F, Yang C, Chen S, Huang Y, Yu S, Zhou Y, Ran P
Received 10 September 2025
Accepted for publication 14 November 2025
Published 25 November 2025 Volume 2025:20 Pages 3791—3802
DOI https://doi.org/10.2147/COPD.S566651
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 5
Editor who approved publication: Dr Vanesa Bellou
Yuemao Li,1,* Jingwen Li,1,* Suyin Huang,1,2,* Fan Wu,1,* Zhishan Deng,1 Jieqi Peng,1,2 Kunning Zhou,1 Gaoying Tang,1 Qi Wan,1 Cuiqiong Dai,1 Lifei Lu,1 Xiaohui Wu,1,2 Xianliang Zeng,1 Fangyan Wu,1 Changli Yang,3 Shengtang Chen,4 Yongqing Huang,5 Shuqing Yu,6 Yumin Zhou,1,2 Pixin Ran1,2
1State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of China; 2Guangzhou National Laboratory, Guangzhou, People’s Republic of China; 3Department of Pulmonary Medicine, Wengyuan County People’s Hospital, Shaoguan, People’s Republic of China; 4Department of Radiology, Wengyuan County People’s Hospital, Shaoguan, People’s Republic of China; 5Intensive Care Unit, Lianping County People’s Hospital, Heyuan, People’s Republic of China; 6Department of Pulmonary Medicine, Lianping County People’s Hospital & Lianping County Second People’s Hospital, Heyuan, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yumin Zhou, Email zhouyumin410@126.com Pixin Ran, Email pxran@gzhmu.edu.cn
Purpose: This study aimed to evaluate the association between the forced expiratory volume in 3 s (FEV3) to forced vital capacity (FVC) and computed tomography (CT)-defined abnormalities, and to assess its potential value in predicting incident chronic obstructive pulmonary disease (COPD) over a 3-year period.
Participants and Methods: This 3-year community-based cohort study enrolled participants with normal lung function (post-bronchodilator FEV1/FVC ≥ 0.70 and FEV1 ≥ 80% predicted). Baseline assessments included questionnaires, spirometry, CT scans, and impulse oscillometry. Participants were stratified by post-bronchodilator FEV3/FVC tertiles. Outcomes included acute respiratory events, annual lung function decline, and COPD incidence. Data were analyzed using mixed-effects models, log-binomial regression, and zero-inflated negative binomial models.
Results: Of the 981 participants with normal baseline lung function stratified by post-bronchodilator FEV3/FVC tertiles (high: ≥ 95.5%, medium: 91.9– 95.4%, low: ≤ 91.8%), 807 completed the 3-year follow-up. Compared to the high-FEV3/FVC group, participants in the low-FEV3/FVC group tended to be older (60.5 vs 55.7 years) and included more males (80.4% vs 38.8%) and smokers. The low-FEV3/FVC group also demonstrated a lower baseline post-bronchodilator FEV1/FVC (74.0% vs 85.1%) and higher prevalence of emphysema (53.5% vs 18.3%). Longitudinal analysis revealed a greater annual post-bronchodilator FEV1 decline in the low-FEV3/FVC group (adjusted mean difference: 10 mL, 95% confidence interval [CI]: 0 to 21mL; p = 0.043) and an increased risk of developing COPD (19.4% versus 1.9%; adjusted relative risk: 4.96, 95% CI: 1.96– 12.51; p = 0.001) than the high-FEV3/FVC group, with no difference in acute respiratory events.
Conclusion: A reduced FEV3/FVC ratio was associated with an increased risk of accelerated lung function decline and progression to COPD in individuals with normal spirometry. As a readily accessible measure derived from routine spirometry, FEV3/FVC may have a role in early COPD detection.
Keywords: forced expiratory volume in 3 s, forced vital capacity, small airway dysfunction, lung function decline, pre-COPD
1State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of China; 2Guangzhou National Laboratory, Guangzhou, People’s Republic of China; 3Department of Pulmonary Medicine, Wengyuan County People’s Hospital, Shaoguan, People’s Republic of China; 4Department of Radiology, Wengyuan County People’s Hospital, Shaoguan, People’s Republic of China; 5Intensive Care Unit, Lianping County People’s Hospital, Heyuan, People’s Republic of China; 6Department of Pulmonary Medicine, Lianping County People’s Hospital & Lianping County Second People’s Hospital, Heyuan, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yumin Zhou, Email zhouyumin410@126.com Pixin Ran, Email pxran@gzhmu.edu.cn
Purpose: This study aimed to evaluate the association between the forced expiratory volume in 3 s (FEV3) to forced vital capacity (FVC) and computed tomography (CT)-defined abnormalities, and to assess its potential value in predicting incident chronic obstructive pulmonary disease (COPD) over a 3-year period.
Participants and Methods: This 3-year community-based cohort study enrolled participants with normal lung function (post-bronchodilator FEV1/FVC ≥ 0.70 and FEV1 ≥ 80% predicted). Baseline assessments included questionnaires, spirometry, CT scans, and impulse oscillometry. Participants were stratified by post-bronchodilator FEV3/FVC tertiles. Outcomes included acute respiratory events, annual lung function decline, and COPD incidence. Data were analyzed using mixed-effects models, log-binomial regression, and zero-inflated negative binomial models.
Results: Of the 981 participants with normal baseline lung function stratified by post-bronchodilator FEV3/FVC tertiles (high: ≥ 95.5%, medium: 91.9– 95.4%, low: ≤ 91.8%), 807 completed the 3-year follow-up. Compared to the high-FEV3/FVC group, participants in the low-FEV3/FVC group tended to be older (60.5 vs 55.7 years) and included more males (80.4% vs 38.8%) and smokers. The low-FEV3/FVC group also demonstrated a lower baseline post-bronchodilator FEV1/FVC (74.0% vs 85.1%) and higher prevalence of emphysema (53.5% vs 18.3%). Longitudinal analysis revealed a greater annual post-bronchodilator FEV1 decline in the low-FEV3/FVC group (adjusted mean difference: 10 mL, 95% confidence interval [CI]: 0 to 21mL; p = 0.043) and an increased risk of developing COPD (19.4% versus 1.9%; adjusted relative risk: 4.96, 95% CI: 1.96– 12.51; p = 0.001) than the high-FEV3/FVC group, with no difference in acute respiratory events.
Conclusion: A reduced FEV3/FVC ratio was associated with an increased risk of accelerated lung function decline and progression to COPD in individuals with normal spirometry. As a readily accessible measure derived from routine spirometry, FEV3/FVC may have a role in early COPD detection.
Keywords: forced expiratory volume in 3 s, forced vital capacity, small airway dysfunction, lung function decline, pre-COPD