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已发表论文
STAT3 在骨关节炎中的关键作用：从致病机制到靶向治疗
Authors Zhao S, Xu H, Chen J , Zhang H, Dong S, Yang Y , Li Z
Received 4 August 2025
Accepted for publication 13 November 2025
Published 24 November 2025 Volume 2025:20 Pages 14075—14096
DOI https://doi.org/10.2147/IJN.S558209
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Yan Shen
Siming Zhao,1,* Haijia Xu,2,* Jian Chen,2 Haoyu Zhang,1 Shangyan Dong,1 Yi Yang,1 Zhanghua Li2
1College of Sports Medicine, Wuhan Sports University, Wuhan, Hubei, 430079, People’s Republic of China; 2Department of Orthopedics, Wuhan Third Hospital, Tongren Hospital of Wuhan University, Wuhan, 430060, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Zhanghua Li, Department of Orthopedics, Wuhan Third Hospital, Tongren Hospital of Wuhan University, Wuhan, 430060, People’s Republic of China, Email lizhanghua_123@163.com
Abstract: Osteoarthritis (OA) is a multifactorial degenerative disease characterized by articular cartilage degeneration. Currently, the underlying mechanisms of its pathogenesis remain unclear, and effective treatment options are limited. Signal transducer and activator of transcription 3 (STAT3) is a key transcription factor involved in various physiological and pathological processes, and recent evidence suggests its association with the pathogenesis of OA. Janus kinase (JAK)/interleukin-6/STAT3 signaling pathway plays an important role in STAT3 involved in disease occurrence. This review summarizes the common signaling pathways involving STAT3 in OA and its roles in different cell types. Additionally, we systematically discuss the latest therapeutic approaches targeting STAT3 for OA treatment, aiming to identify drugs that can enhance delivery efficiency and binding affinity. By discussing molecular mechanisms and treatment methods, this review provides a foundation for subsequent research on the STAT3 signaling pathway and OA.
Keywords: STAT3, JAK, osteoarthritis, signaling pathway, targeted therapy
1College of Sports Medicine, Wuhan Sports University, Wuhan, Hubei, 430079, People’s Republic of China; 2Department of Orthopedics, Wuhan Third Hospital, Tongren Hospital of Wuhan University, Wuhan, 430060, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Zhanghua Li, Department of Orthopedics, Wuhan Third Hospital, Tongren Hospital of Wuhan University, Wuhan, 430060, People’s Republic of China, Email lizhanghua_123@163.com
Abstract: Osteoarthritis (OA) is a multifactorial degenerative disease characterized by articular cartilage degeneration. Currently, the underlying mechanisms of its pathogenesis remain unclear, and effective treatment options are limited. Signal transducer and activator of transcription 3 (STAT3) is a key transcription factor involved in various physiological and pathological processes, and recent evidence suggests its association with the pathogenesis of OA. Janus kinase (JAK)/interleukin-6/STAT3 signaling pathway plays an important role in STAT3 involved in disease occurrence. This review summarizes the common signaling pathways involving STAT3 in OA and its roles in different cell types. Additionally, we systematically discuss the latest therapeutic approaches targeting STAT3 for OA treatment, aiming to identify drugs that can enhance delivery efficiency and binding affinity. By discussing molecular mechanisms and treatment methods, this review provides a foundation for subsequent research on the STAT3 signaling pathway and OA.
Keywords: STAT3, JAK, osteoarthritis, signaling pathway, targeted therapy