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已发表论文
多组学揭示妊娠期高血压患者肠道微生物群失调驱动脂质代谢紊乱和炎症反应
Authors Tian S, Liu Y, Yang H, Chen K, Li J, Chen L, Wu T, Zhang L
Received 19 June 2025
Accepted for publication 9 November 2025
Published 24 November 2025 Volume 2025:18 Pages 16411—16425
DOI https://doi.org/10.2147/JIR.S548338
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Qing Lin
Suochen Tian,1,* Yanjun Liu,2,* Hanyi Yang,1,3 Kexin Chen,2,4 Jingpo Li,1 Li Chen,2 Tiejun Wu,1 Lina Zhang1
1Intensive Care Unit, Liaocheng People’s Hospital, Liaocheng, Shandong, 252000, People’s Republic of China; 2Department of Gynaecology and Obstetrics, Liaocheng People’s Hospital, Liaocheng, Shandong, 252000, People’s Republic of China; 3School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, 261053, People’s Republic of China; 4Department of Postgraduates, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, 250117, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Tiejun Wu, Intensive Care Unit, Liaocheng People’s Hospital, No. 62 Dongchang Road, Liaocheng, Shandong, 252000, People’s Republic of China, Email tiejunwu@hotmail.com Lina Zhang, Intensive Care Unit, Liaocheng People’s Hospital, No. 62 Dongchang Road, Liaocheng, Shandong, 252000, People’s Republic of China, Email LchCICU@163.com
Background: Gestational hypertension (GH) is a common complication during pregnancy that poses serious health risks to both mother and fetus. Recent studies have underscored the potential roles of gut microbiota, lipid metabolism, and inflammatory response in GH’s development and progression. However, the exact mechanisms behind these interactions are still unclear. Understanding how gut microbial composition impacts lipid metabolism and inflammation could offer valuable insights into GH’s pathogenesis and may lead to new prevention and treatment methods.
Methods: In this study, we conducted ELISA experiments to detect inflammatory cytokines in the serum of GH patients. Additionally, we performed 16S-rDNA sequencing analysis on the feces of GH patients to investigate the characteristics of their intestinal microbial communities; GH mouse model was constructed to assess the impact of intestinal flora on offspring. Furthermore, we utilized non-targeted lipid metabolomics to analyze lipid metabolic characteristics in the feces and blood of GH patients and established connections between the microbiome and lipidome through correlation analysis.
Results: ELISA tests suggested the levels of inflammatory factors in the serum of GH patients increased significantly, including IL-6, IL-8, IL-17, IL-18, and IFN-γ. In comparison to the normal group, the GH group exhibited a marked reduction in microbial richness. LEfSe analysis found 16 distinct bacterial communities between the two groups. Animal models suggested that fecal microbiota transplantation from the GH group’s intestinal flora resulted in a significant decrease in the birth weight of the offspring. Furthermore, comparative analysis of fecal and blood metabolic profiles suggested that TG (54:5/FA22:5) may serve as a key metabolite. Correlation analysis demonstrated that f-Oxalobacteraceae exhibited a significant negative correlation with the inflammatory factor IL-17 and TG (54:5/FA22:5) in the blood, while showing a significant positive correlation with g-Oxalobacter and s-formigenes.
Conclusion: Our results establish a connection between gut microbiota, lipid metabolism, and the inflammatory response in patients with GH. This understanding may enhance our comprehension of the underlying mechanisms associated with GH.
Keywords: gestational hypertension, lipid metabolism, gut microbes, inflammation
1Intensive Care Unit, Liaocheng People’s Hospital, Liaocheng, Shandong, 252000, People’s Republic of China; 2Department of Gynaecology and Obstetrics, Liaocheng People’s Hospital, Liaocheng, Shandong, 252000, People’s Republic of China; 3School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, 261053, People’s Republic of China; 4Department of Postgraduates, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, 250117, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Tiejun Wu, Intensive Care Unit, Liaocheng People’s Hospital, No. 62 Dongchang Road, Liaocheng, Shandong, 252000, People’s Republic of China, Email tiejunwu@hotmail.com Lina Zhang, Intensive Care Unit, Liaocheng People’s Hospital, No. 62 Dongchang Road, Liaocheng, Shandong, 252000, People’s Republic of China, Email LchCICU@163.com
Background: Gestational hypertension (GH) is a common complication during pregnancy that poses serious health risks to both mother and fetus. Recent studies have underscored the potential roles of gut microbiota, lipid metabolism, and inflammatory response in GH’s development and progression. However, the exact mechanisms behind these interactions are still unclear. Understanding how gut microbial composition impacts lipid metabolism and inflammation could offer valuable insights into GH’s pathogenesis and may lead to new prevention and treatment methods.
Methods: In this study, we conducted ELISA experiments to detect inflammatory cytokines in the serum of GH patients. Additionally, we performed 16S-rDNA sequencing analysis on the feces of GH patients to investigate the characteristics of their intestinal microbial communities; GH mouse model was constructed to assess the impact of intestinal flora on offspring. Furthermore, we utilized non-targeted lipid metabolomics to analyze lipid metabolic characteristics in the feces and blood of GH patients and established connections between the microbiome and lipidome through correlation analysis.
Results: ELISA tests suggested the levels of inflammatory factors in the serum of GH patients increased significantly, including IL-6, IL-8, IL-17, IL-18, and IFN-γ. In comparison to the normal group, the GH group exhibited a marked reduction in microbial richness. LEfSe analysis found 16 distinct bacterial communities between the two groups. Animal models suggested that fecal microbiota transplantation from the GH group’s intestinal flora resulted in a significant decrease in the birth weight of the offspring. Furthermore, comparative analysis of fecal and blood metabolic profiles suggested that TG (54:5/FA22:5) may serve as a key metabolite. Correlation analysis demonstrated that f-Oxalobacteraceae exhibited a significant negative correlation with the inflammatory factor IL-17 and TG (54:5/FA22:5) in the blood, while showing a significant positive correlation with g-Oxalobacter and s-formigenes.
Conclusion: Our results establish a connection between gut microbiota, lipid metabolism, and the inflammatory response in patients with GH. This understanding may enhance our comprehension of the underlying mechanisms associated with GH.
Keywords: gestational hypertension, lipid metabolism, gut microbes, inflammation