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已发表论文
长期卧床状态作为社区获得性肺炎老年患者院内死亡率的预测因素：一项回顾性队列研究
Received 16 July 2025
Accepted for publication 13 November 2025
Published 22 November 2025 Volume 2025:20 Pages 2145—2151
DOI https://doi.org/10.2147/CIA.S554154
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Prof. Dr. Nandu Goswami
Zheng Wang, Dong Wu
Department of Geriatrics, Peking University Third Hospital, Beijing, People’s Republic of China
Correspondence: Zheng Wang, Email zhwang2011@bjmu.edu.cn
Background: Long-term bedridden elderly individuals face a high risk of community-acquired pneumonia (CAP) amid China’s aging population, yet the specific mortality impact remains insufficiently studied.
Objective: To compare the clinical characteristics and in-hospital mortality between long-term bedridden and ambulatory elderly patients with CAP, and to identify risk factors for mortality.
Methods: This retrospective study included 453 patients aged ≥ 75 years hospitalized with CAP from March 2016 to March 2019, divided into a bedridden group (n = 162) and a non-bedridden group (n = 291). Data on demographics, comorbidities, frailty (modified Frailty Index-5, mFI-5), functional status (Barthel Index), and laboratory parameters (eg, hs-CRP) were collected. Logistic regression analysis was used to identify predictors of in-hospital mortality.
Results: The bedridden group had a significantly higher mortality rate (27.16% vs 2.06%, P < 0.001) and elevated hs-CRP levels (40.2 ± 44.0 mg/L vs 19.9 ± 20.3 mg/L). Multivariate analysis identified bedridden status (OR = 11.99, 95% CI: 4.31– 33.40), respiratory failure (OR = 6.80, 95% CI: 3.03– 15.28), and renal dysfunction (elevated serum creatinine; OR = 1.01, 95% CI: 1.00– 1.02) as independent risk factors for mortality.
Conclusion: Long-term bedridden status is an independent predictor of in-hospital mortality in elderly CAP patients with inflammatory response potentially playing a critical role.
Keywords: bedridden status, community-acquired pneumonia, frailty, inflammation, hs-CRP, mortality
Department of Geriatrics, Peking University Third Hospital, Beijing, People’s Republic of China
Correspondence: Zheng Wang, Email zhwang2011@bjmu.edu.cn
Background: Long-term bedridden elderly individuals face a high risk of community-acquired pneumonia (CAP) amid China’s aging population, yet the specific mortality impact remains insufficiently studied.
Objective: To compare the clinical characteristics and in-hospital mortality between long-term bedridden and ambulatory elderly patients with CAP, and to identify risk factors for mortality.
Methods: This retrospective study included 453 patients aged ≥ 75 years hospitalized with CAP from March 2016 to March 2019, divided into a bedridden group (n = 162) and a non-bedridden group (n = 291). Data on demographics, comorbidities, frailty (modified Frailty Index-5, mFI-5), functional status (Barthel Index), and laboratory parameters (eg, hs-CRP) were collected. Logistic regression analysis was used to identify predictors of in-hospital mortality.
Results: The bedridden group had a significantly higher mortality rate (27.16% vs 2.06%, P < 0.001) and elevated hs-CRP levels (40.2 ± 44.0 mg/L vs 19.9 ± 20.3 mg/L). Multivariate analysis identified bedridden status (OR = 11.99, 95% CI: 4.31– 33.40), respiratory failure (OR = 6.80, 95% CI: 3.03– 15.28), and renal dysfunction (elevated serum creatinine; OR = 1.01, 95% CI: 1.00– 1.02) as independent risk factors for mortality.
Conclusion: Long-term bedridden status is an independent predictor of in-hospital mortality in elderly CAP patients with inflammatory response potentially playing a critical role.
Keywords: bedridden status, community-acquired pneumonia, frailty, inflammation, hs-CRP, mortality