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已发表论文
通过认知与运动双重任务步态训练改善脑卒中后认知障碍：潜在机制及临床价值
Authors Cao J , Hu P, Li L , Dai F, Jin Y
Received 21 August 2025
Accepted for publication 14 November 2025
Published 21 November 2025 Volume 2025:21 Pages 2559—2573
DOI https://doi.org/10.2147/NDT.S562404
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 4
Editor who approved publication: Professor Taro Kishi
Jianping Cao,1 Peiyan Hu,1 Ling Li,2 Fangyu Dai,2 Ying Jin3
1Department of Rehabilitation Medicine, Zhoushan Hospital, Zhoushan, 316000, People’s Republic of China; 2Department of Neurology, Zhoushan Hospital, Zhoushan, 316000, People’s Republic of China; 3Department of Rehabilitation Medicine, The Second Affiliated Hospital, Zhejiang University, Hangzhou, 310052, People’s Republic of China
Correspondence: Ying Jin, Department of Rehabilitation Medicine, The Second Affiliated Hospital, Zhejiang University, No. 1511 Jianghong Road, Binjiang District, Hangzhou, 310052, People’s Republic of China, Tel +86-571-56055985, Email yingjin666@zju.edu.cn
Abstract: Post-stroke cognitive impairment (PSCI) severely impacts patients’ quality of life and functional recovery, with its incidence rising alongside global population aging. Cognitive-walking dual-task training, which integrates cognitive and motor elements, has emerged as a key focus in rehabilitation research in recent years. This review summarizes its value and neural mechanisms in improving PSCI. By integrating randomized controlled trials and functional imaging studies, it assesses the training’s effects on cognitive and motor functions and reveals the association between brain region activation and cognitive recovery. The training can enhance cognitive abilities such as attention and executive function, improve motor functions including gait and balance, and boost quality of life. It promotes neuroplasticity, strengthens activation and connectivity of key brain regions like the prefrontal cortex, and regulates Brain-derived neurotrophic factor (BDNF) expression. Technologies such as Functional Near-Infrared Spectroscopy (fNIRS) and Functional magnetic resonance imaging (fMRI) confirm its role in brain function remodeling, and it outperforms traditional training and aerobic exercise alone in enhancing dual-task performance. This training provides a basis for PSCI rehabilitation. Future research should optimize individualized protocols, verify long-term efficacy, and advance the application of multimodal imaging and intelligent platforms to refine rehabilitation strategies.
Keywords: dual task training, walking rehabilitation, stroke, cognitive impairment, neural mechanisms
1Department of Rehabilitation Medicine, Zhoushan Hospital, Zhoushan, 316000, People’s Republic of China; 2Department of Neurology, Zhoushan Hospital, Zhoushan, 316000, People’s Republic of China; 3Department of Rehabilitation Medicine, The Second Affiliated Hospital, Zhejiang University, Hangzhou, 310052, People’s Republic of China
Correspondence: Ying Jin, Department of Rehabilitation Medicine, The Second Affiliated Hospital, Zhejiang University, No. 1511 Jianghong Road, Binjiang District, Hangzhou, 310052, People’s Republic of China, Tel +86-571-56055985, Email yingjin666@zju.edu.cn
Abstract: Post-stroke cognitive impairment (PSCI) severely impacts patients’ quality of life and functional recovery, with its incidence rising alongside global population aging. Cognitive-walking dual-task training, which integrates cognitive and motor elements, has emerged as a key focus in rehabilitation research in recent years. This review summarizes its value and neural mechanisms in improving PSCI. By integrating randomized controlled trials and functional imaging studies, it assesses the training’s effects on cognitive and motor functions and reveals the association between brain region activation and cognitive recovery. The training can enhance cognitive abilities such as attention and executive function, improve motor functions including gait and balance, and boost quality of life. It promotes neuroplasticity, strengthens activation and connectivity of key brain regions like the prefrontal cortex, and regulates Brain-derived neurotrophic factor (BDNF) expression. Technologies such as Functional Near-Infrared Spectroscopy (fNIRS) and Functional magnetic resonance imaging (fMRI) confirm its role in brain function remodeling, and it outperforms traditional training and aerobic exercise alone in enhancing dual-task performance. This training provides a basis for PSCI rehabilitation. Future research should optimize individualized protocols, verify long-term efficacy, and advance the application of multimodal imaging and intelligent platforms to refine rehabilitation strategies.
Keywords: dual task training, walking rehabilitation, stroke, cognitive impairment, neural mechanisms