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已发表论文
神经调节干预对伴有共病的自闭症谱系障碍的疗效和安全性：一项系统综述
Authors Wu X , Huangfu J, Zhang W, Hu Y, Yang L, Wei J, Chen Z, Geng S, Xue S, Yi P, Mao Y, Qian D, Wang X, Zhang P , Long H
Received 4 September 2025
Accepted for publication 18 November 2025
Published 4 December 2025 Volume 2025:21 Pages 2759—2782
DOI https://doi.org/10.2147/NDT.S565304
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Professor Taro Kishi
Xiaoyan Wu,1– 3,* Junnan Huangfu,1– 3,* Wanghao Zhang,1– 3 Yuchen Hu,1– 3 Lu Yang,1,2 Jiezuo Wei,1,2 Zijian Chen,1– 3 Shiqin Geng,1,2 Shuaishuai Xue,1,2 Peiyao Yi,1,2 Yangqi Mao,1,2 Dadi Qian,1,2 Xingqin Wang,1,2 Peidong Zhang,1,2 Hao Long1,2
1Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China; 2Institute of Brain Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China; 3The First Clinical Medical College, Southern Medical University, Guangzhou, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Peidong Zhang, Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China, Email zhangpd2310@smu.edu.cn Hao Long, Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China, Email longhao@smu.edu.cn
Purpose: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social communication and stereotyped, repetitive behaviors or interests. Neuromodulation interventions have been employed in ASD, which can improve behavioral and cognitive outcomes in ASD, especially relief of comorbidities, as shown in preliminary evidence. However, their efficacy and safety remain unclear owing to the lack of high-quality synthetic evidence. We aim to systematically evaluate the therapeutic potential of neurostimulation in ASD and explore its underlying mechanisms.
Patients and Methods: A narrative synthesis of peer-reviewed literature from 2000 to 2025 was conducted, sourced from the PubMed, Web of Science, and Cochrane Library. Seventy-three relevant studies were identified in this paper.
Results: Up to date, noninvasive brain stimulation has become a potential intervention to reduce autism-related symptoms and improve neuropsychological function in ASDs, while a marked alleviation of comorbidities including aggression, anxiety and epilepsy was observed following invasive brain stimulation interventions. Both of the neuromodulation techniques are believed to be safe and well-tolerated.
Conclusion: Neuromodulation interventions could be a hopeful option to improve patients’ symptoms and control comorbidities of ASD. Further high-quality trials should be conducted to optimize long-term prognosis of ASD.
Keywords: autism spectrum disorder, comorbidities, noninvasive brain stimulation, invasive brain stimulation
1Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China; 2Institute of Brain Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China; 3The First Clinical Medical College, Southern Medical University, Guangzhou, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Peidong Zhang, Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China, Email zhangpd2310@smu.edu.cn Hao Long, Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China, Email longhao@smu.edu.cn
Purpose: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social communication and stereotyped, repetitive behaviors or interests. Neuromodulation interventions have been employed in ASD, which can improve behavioral and cognitive outcomes in ASD, especially relief of comorbidities, as shown in preliminary evidence. However, their efficacy and safety remain unclear owing to the lack of high-quality synthetic evidence. We aim to systematically evaluate the therapeutic potential of neurostimulation in ASD and explore its underlying mechanisms.
Patients and Methods: A narrative synthesis of peer-reviewed literature from 2000 to 2025 was conducted, sourced from the PubMed, Web of Science, and Cochrane Library. Seventy-three relevant studies were identified in this paper.
Results: Up to date, noninvasive brain stimulation has become a potential intervention to reduce autism-related symptoms and improve neuropsychological function in ASDs, while a marked alleviation of comorbidities including aggression, anxiety and epilepsy was observed following invasive brain stimulation interventions. Both of the neuromodulation techniques are believed to be safe and well-tolerated.
Conclusion: Neuromodulation interventions could be a hopeful option to improve patients’ symptoms and control comorbidities of ASD. Further high-quality trials should be conducted to optimize long-term prognosis of ASD.
Keywords: autism spectrum disorder, comorbidities, noninvasive brain stimulation, invasive brain stimulation