111614
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
针刺与中药协同作用对大鼠脑梗死的影响：短链脂肪酸和白细胞介素 - 17 的作用
Authors Kang Z, Lin P, Chen Z, Ye H , Fang L, Zhang P
Received 19 September 2025
Accepted for publication 26 November 2025
Published 3 December 2025 Volume 2025:18 Pages 7231—7242
DOI https://doi.org/10.2147/IJGM.S566274
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Redoy Ranjan
Zhen Kang,1,* Peiyi Lin,1,2,* Zhuangzhi Chen,1 Haimin Ye,1 Linglang Fang,1,2 Peng Zhang1
1The Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, 410005, People’s Republic of China; 2Hunan University of Chinese Medicine, Changsha, Hunan, 410208, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Peng Zhang, Acupuncture and Massage Rehabilitation Center, The Second Affiliated Hospital of Hunan University of Chinese Medicine, No. 233 Cai’e North Road, Kaifu District, Changsha, Hunan, 410005, People’s Republic of China, Tel +86 13548561082, Fax +86 731 84912978, Email 35401725@qq.com
Purpose: To investigate the synergistic effect of Acupuncture combined with Chinese Herbal Medicine (CHM) in treating cerebral infarction (CI) rats, focusing on its impact on gut short-chain fatty acids (SCFAs) and serum interleukin-17 (IL-17) expression.
Methods: 36 male SD rats were divided into 6 groups (n=6): Sham, Model, Acupuncture, CHM, Combined Therapy, and Western Medicine (positive control). The CI model was established by middle cerebral artery occlusion (MCAO). The Combined group received both acupuncture (at bilateral “Hegu” (LI4), “Taichong” (LR3), “Zusanli” (ST36), and “Fenglong” (ST40)) and CHM (oral Banxia Baizhu Tianma Decoction combined with Taoren Honghua Decoction). Treatment lasted 14 days. Neurological deficit scores (Longa and horizontal wooden stick tests) were assessed. SCFA content in colonic contents was analyzed by gas chromatography, and serum IL-17 levels by ELISA. Subsequently, the correlation between SCFAs and IL-17 levels was analyzed.
Results: The combined therapy group showed significantly better improvements in neurological function compared to all single-therapy groups (P < 0.05). Compared to the model group, the total content of SCFAs (including acetic acid, propionic acid, and butyric acid) was significantly lower in the model group, while IL-17 levels were significantly elevated. All treatment groups showed increased SCFA content and decreased IL-17 levels, with the combined group demonstrating superior effects compared to single therapies (P < 0.05). A significant negative correlation was found between total SCFAs, acetic acid, propionic acid, and butyric acid, and serum IL-17 (R2 = 0.601– 0.711, P < 0.05).
Conclusion: The combination of acupuncture and CHM significantly improved neurological deficits in CI rats. This synergistic effect is likely associated with the regulation of gut microbiota-derived SCFAs and the suppression of IL-17-mediated neuroinflammation.
Keywords: cerebral infarction, acupuncture plus Chinese herbs, short-chain fatty acids, gut microbiota, interleukin-17
1The Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, 410005, People’s Republic of China; 2Hunan University of Chinese Medicine, Changsha, Hunan, 410208, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Peng Zhang, Acupuncture and Massage Rehabilitation Center, The Second Affiliated Hospital of Hunan University of Chinese Medicine, No. 233 Cai’e North Road, Kaifu District, Changsha, Hunan, 410005, People’s Republic of China, Tel +86 13548561082, Fax +86 731 84912978, Email 35401725@qq.com
Purpose: To investigate the synergistic effect of Acupuncture combined with Chinese Herbal Medicine (CHM) in treating cerebral infarction (CI) rats, focusing on its impact on gut short-chain fatty acids (SCFAs) and serum interleukin-17 (IL-17) expression.
Methods: 36 male SD rats were divided into 6 groups (n=6): Sham, Model, Acupuncture, CHM, Combined Therapy, and Western Medicine (positive control). The CI model was established by middle cerebral artery occlusion (MCAO). The Combined group received both acupuncture (at bilateral “Hegu” (LI4), “Taichong” (LR3), “Zusanli” (ST36), and “Fenglong” (ST40)) and CHM (oral Banxia Baizhu Tianma Decoction combined with Taoren Honghua Decoction). Treatment lasted 14 days. Neurological deficit scores (Longa and horizontal wooden stick tests) were assessed. SCFA content in colonic contents was analyzed by gas chromatography, and serum IL-17 levels by ELISA. Subsequently, the correlation between SCFAs and IL-17 levels was analyzed.
Results: The combined therapy group showed significantly better improvements in neurological function compared to all single-therapy groups (P < 0.05). Compared to the model group, the total content of SCFAs (including acetic acid, propionic acid, and butyric acid) was significantly lower in the model group, while IL-17 levels were significantly elevated. All treatment groups showed increased SCFA content and decreased IL-17 levels, with the combined group demonstrating superior effects compared to single therapies (P < 0.05). A significant negative correlation was found between total SCFAs, acetic acid, propionic acid, and butyric acid, and serum IL-17 (R2 = 0.601– 0.711, P < 0.05).
Conclusion: The combination of acupuncture and CHM significantly improved neurological deficits in CI rats. This synergistic effect is likely associated with the regulation of gut microbiota-derived SCFAs and the suppression of IL-17-mediated neuroinflammation.
Keywords: cerebral infarction, acupuncture plus Chinese herbs, short-chain fatty acids, gut microbiota, interleukin-17