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已发表论文
慢性阻塞性肺疾病急性加重期虚弱对日常生活活动能力及住院时间的影响
Authors Liu Y , Lin D, He J, Zhao Y , Wang Z, Wang Y, Yang M
Received 14 June 2025
Accepted for publication 19 November 2025
Published 3 December 2025 Volume 2025:20 Pages 3923—3937
DOI https://doi.org/10.2147/COPD.S547114
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Richard Russell
Yang Liu,1 Dier Lin,2 Jie He,3 Yangyang Zhao,4 Ziwei Wang,5 Yali Wang,6 Mengjiao Yang6
1Key Laboratory of Digital-Intelligent Disease Surveillance and Health Governance, North Sichuan Medical College, Nanchong City, Sichuan Province, 637000, People’s Republic of China; 2Department of Post Anesthesia Care Unit, Affiliated Hospital of North Sichuan Medical College, Nanchong City, Sichuan Province, 637000, People’s Republic of China; 3Department of Nursing, Affiliated Hospital of North Sichuan Medical College, Nanchong City, Sichuan Province, 637000, People’s Republic of China; 4Department of Blood Transfusion, Affiliated Hospital of North Sichuan Medical College, Nanchong City, Sichuan Province, 637000, People’s Republic of China; 5Department of Respiratory and Critical Care Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong City, Sichuan Province, 637000, People’s Republic of China; 6Department of Cardiovascular Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong City, Sichuan Province, 637000, People’s Republic of China
Correspondence: Mengjiao Yang, Department of Cardiovascular Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong City, Sichuan Province, 637000, People’s Republic of China, Tel +86-152-8175-5358, Email yangmengjiao68@gmail.com
Purpose: The current study aimed to investigate the prevalence of pre-frailty and frailty for hospitalized patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) and to quantify their relationship with Activities of Daily Living (ADL) and length of hospitalization.
Patients and Methods: We investigated frailty status, ADL ability, and length of hospitalization for 295 patients with AECOPD who were admitted to the respiratory department of a large tertiary care institution in Sichuan Province, China, between August 2022 and June 2023. Descriptive statistical methods were used to describe their demographic characteristics, frailty prevalence, ADL ability, and length of hospitalization. Following this, we developed two linear regression models to explore the cross-sectional association between different frailty statuses and ADL ability, as well as the longitudinal association between frailty status and length of hospitalization.
Results: Statistical evidence indicated that 39.3% and 46.1% of the patients exhibited pre-frailty and frailty, respectively. A multivariate linear regression model, which adjusted for significant variables, indicated that pre-frailty (coefficient [β] = 1.90, confidence interval [CI] = 0.76– 3.04) and frailty (β = 2.02, CI = 0.84– 3.20) were significantly associated with longer hospital stays, even in a fully adjusted model. Additionally, although pre-frailty (β = – 4.79, CI = – 8.98 to – 0.60) and frailty (β = – 4.48, CI = – 8.81 to – 0.15) were associated with worse ADL in a significant variable-adjusted model, the fully adjusted model indicated that no significant association was found between frailty and ADL.
Conclusion: Patients with AECOPD have a high prevalence of pre-frailty and frailty. More frail patients tend to have longer hospitalizations, and pre-frailty is associated with poorer ADL. However, the association of frailty with ADL requires further validation.
Plain Language Summary: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide among chronic diseases. Patients with COPD often experience increased frailty, along with significant physical, psychological, and financial distress due to repeated and prolonged acute exacerbations. However, frailty in patients with acute exacerbation of COPD (AECOPD) is frequently overlooked in clinical practice. This unrecognized frailty can be linked to impaired physical functioning and may result in extended hospitalization. The current study analyzed the experiences of 295 patients with AECOPD in an economically underdeveloped area in northeast Sichuan Province, focusing on frailty, Activities of daily living (ADL), and length of hospitalization. The results revealed that 85.4% of patients displayed varying degrees of frailty, with 39.3% considered pre-frail and 46.1% classified as frail. Pre-frailty was frequently associated with ADL disabilities. Both pre-frailty and frailty were found to predict longer length of hospitalization. Consequently, incorporating frailty screening into clinical practice and considering a categorized management strategy for patients with AECOPD could effectively reduce the burden on these patients.
Keywords: frailty, AECOPD, ADL, length of hospitalization
1Key Laboratory of Digital-Intelligent Disease Surveillance and Health Governance, North Sichuan Medical College, Nanchong City, Sichuan Province, 637000, People’s Republic of China; 2Department of Post Anesthesia Care Unit, Affiliated Hospital of North Sichuan Medical College, Nanchong City, Sichuan Province, 637000, People’s Republic of China; 3Department of Nursing, Affiliated Hospital of North Sichuan Medical College, Nanchong City, Sichuan Province, 637000, People’s Republic of China; 4Department of Blood Transfusion, Affiliated Hospital of North Sichuan Medical College, Nanchong City, Sichuan Province, 637000, People’s Republic of China; 5Department of Respiratory and Critical Care Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong City, Sichuan Province, 637000, People’s Republic of China; 6Department of Cardiovascular Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong City, Sichuan Province, 637000, People’s Republic of China
Correspondence: Mengjiao Yang, Department of Cardiovascular Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong City, Sichuan Province, 637000, People’s Republic of China, Tel +86-152-8175-5358, Email yangmengjiao68@gmail.com
Purpose: The current study aimed to investigate the prevalence of pre-frailty and frailty for hospitalized patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) and to quantify their relationship with Activities of Daily Living (ADL) and length of hospitalization.
Patients and Methods: We investigated frailty status, ADL ability, and length of hospitalization for 295 patients with AECOPD who were admitted to the respiratory department of a large tertiary care institution in Sichuan Province, China, between August 2022 and June 2023. Descriptive statistical methods were used to describe their demographic characteristics, frailty prevalence, ADL ability, and length of hospitalization. Following this, we developed two linear regression models to explore the cross-sectional association between different frailty statuses and ADL ability, as well as the longitudinal association between frailty status and length of hospitalization.
Results: Statistical evidence indicated that 39.3% and 46.1% of the patients exhibited pre-frailty and frailty, respectively. A multivariate linear regression model, which adjusted for significant variables, indicated that pre-frailty (coefficient [β] = 1.90, confidence interval [CI] = 0.76– 3.04) and frailty (β = 2.02, CI = 0.84– 3.20) were significantly associated with longer hospital stays, even in a fully adjusted model. Additionally, although pre-frailty (β = – 4.79, CI = – 8.98 to – 0.60) and frailty (β = – 4.48, CI = – 8.81 to – 0.15) were associated with worse ADL in a significant variable-adjusted model, the fully adjusted model indicated that no significant association was found between frailty and ADL.
Conclusion: Patients with AECOPD have a high prevalence of pre-frailty and frailty. More frail patients tend to have longer hospitalizations, and pre-frailty is associated with poorer ADL. However, the association of frailty with ADL requires further validation.
Plain Language Summary: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide among chronic diseases. Patients with COPD often experience increased frailty, along with significant physical, psychological, and financial distress due to repeated and prolonged acute exacerbations. However, frailty in patients with acute exacerbation of COPD (AECOPD) is frequently overlooked in clinical practice. This unrecognized frailty can be linked to impaired physical functioning and may result in extended hospitalization. The current study analyzed the experiences of 295 patients with AECOPD in an economically underdeveloped area in northeast Sichuan Province, focusing on frailty, Activities of daily living (ADL), and length of hospitalization. The results revealed that 85.4% of patients displayed varying degrees of frailty, with 39.3% considered pre-frail and 46.1% classified as frail. Pre-frailty was frequently associated with ADL disabilities. Both pre-frailty and frailty were found to predict longer length of hospitalization. Consequently, incorporating frailty screening into clinical practice and considering a categorized management strategy for patients with AECOPD could effectively reduce the burden on these patients.
Keywords: frailty, AECOPD, ADL, length of hospitalization