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已发表论文
基于 2011 - 2018 年美国国家健康与营养调查数据探讨氧化平衡评分与妇科癌症之间的关联
Received 17 July 2025
Accepted for publication 6 November 2025
Published 3 December 2025 Volume 2025:17 Pages 5129—5139
DOI https://doi.org/10.2147/IJWH.S554574
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Everett Magann
Yu’ e Yang,1 Chunfang Ha2
1The First Clinical Medical College of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750000 People’s Republic of China; 2General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750000 People’s Republic of China
Correspondence: Chunfang Ha, General Hospital of Ningxia Medical University, 804 Shengli Street, Xingqing District, Yinchuan, Ningxia Hui Autonomous Region, 750000, People’s Republic of China, Email hachunfang@163.com
Background: Oxidative stress has been implicated in the pathogenesis of various malignancies, including gynecological cancers (GC). This study aimed to evaluate the association between oxidative balance score (OBS) and GC prevalence using data from the National Health and Nutrition Examination Survey (NHANES) 2011– 2018.
Methods: A total of 7816 adult female participants were included, of whom 195 reported a history of GC (cervical, endometrial, or ovarian). OBS was computed from 20 components: 15 antioxidants and five pro-oxidants from dietary and lifestyle sources. Multivariable logistic regression models were used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) for GC according to the OBS tertiles and per-unit increases, adjusting for covariates.
Results: Higher total OBS was associated with significantly lower odds of GC (adjusted OR per unit increase = 0.92; 95% CI: 0.86– 0.97). Participants in the highest OBS tertile had 34% lower odds of developing GC than those in the lowest tertile. This association was more pronounced among women aged ≥ 60 years, non-smokers, and those with normal body mass index (BMI).
Conclusion: Greater antioxidant exposure, as reflected by higher OBS, was inversely associated with GC risk. These findings support dietary and lifestyle interventions aimed at improving oxidative balance.
Keywords: oxidative stress, gynecologic neoplasms, diet, lifestyle, antioxidants
1The First Clinical Medical College of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750000 People’s Republic of China; 2General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750000 People’s Republic of China
Correspondence: Chunfang Ha, General Hospital of Ningxia Medical University, 804 Shengli Street, Xingqing District, Yinchuan, Ningxia Hui Autonomous Region, 750000, People’s Republic of China, Email hachunfang@163.com
Background: Oxidative stress has been implicated in the pathogenesis of various malignancies, including gynecological cancers (GC). This study aimed to evaluate the association between oxidative balance score (OBS) and GC prevalence using data from the National Health and Nutrition Examination Survey (NHANES) 2011– 2018.
Methods: A total of 7816 adult female participants were included, of whom 195 reported a history of GC (cervical, endometrial, or ovarian). OBS was computed from 20 components: 15 antioxidants and five pro-oxidants from dietary and lifestyle sources. Multivariable logistic regression models were used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) for GC according to the OBS tertiles and per-unit increases, adjusting for covariates.
Results: Higher total OBS was associated with significantly lower odds of GC (adjusted OR per unit increase = 0.92; 95% CI: 0.86– 0.97). Participants in the highest OBS tertile had 34% lower odds of developing GC than those in the lowest tertile. This association was more pronounced among women aged ≥ 60 years, non-smokers, and those with normal body mass index (BMI).
Conclusion: Greater antioxidant exposure, as reflected by higher OBS, was inversely associated with GC risk. These findings support dietary and lifestyle interventions aimed at improving oxidative balance.
Keywords: oxidative stress, gynecologic neoplasms, diet, lifestyle, antioxidants