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已发表论文
从针刺到光子：激光针灸治疗失眠的临床疗效、安全性及机制洞察
Authors Zhao FY , Zhang WJ, Chow CM , Xu P, Yue LP, Ho YS, Fu QQ , Conduit R
Received 28 September 2025
Accepted for publication 27 November 2025
Published 2 December 2025 Volume 2025:17 Pages 3105—3114
DOI https://doi.org/10.2147/NSS.S570796
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Prof. Dr. Ahmed BaHammam
Fei-Yi Zhao,1– 4,* Wen-Jing Zhang,4,* Chin Moi Chow,3,5,* Peijie Xu,6 Li-Ping Yue,1 Yuen-Shan Ho,7 Qiang-Qiang Fu,8 Russell Conduit2
1Department of Nursing, School of International Medical Technology, Shanghai Sanda University, Shanghai, 201209, People’s Republic of China; 2School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC, 3083, Australia; 3Sydney School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, 2050, Australia; 4Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200071, People’s Republic of China; 5Sleep Research Group, Charles Perkins Centre, The University of Sydney, Camperdown, NSW, 2050, Australia; 6School of Computing Technologies, RMIT University, Melbourne, VIC, 3000, Australia; 7School of Nursing, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, People’s Republic of China; 8Yangpu Hospital, School of Medicine, Tongji University, Shanghai, 200090, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yuen-Shan Ho, School of Nursing, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, People’s Republic of China, Tel +852 2766-6410, Fax +852 2364-9663, Email janice.ys.ho@polyu.edu.hk Qiang-Qiang Fu, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, 200090, People’s Republic of China, Tel + 86 021-6569 0520, Fax + 86 021-6569 6249, Email qiangqiang.fu@tongji.edu.cn
Abstract: Insomnia constitutes a significant worldwide public health burden. Limitations of conventional treatments, such as cognitive-behavioral therapy and hypnotic medications, have fueled growing interest in complementary and alternative medicine approaches, including laser acupuncture (LA). This comprehensive mini-review evaluates LA’s effects and mechanisms for insomnia management. Clinical evidence indicates that LA alleviates both primary insomnia and comorbid cases (eg, with cancer, hypertension, and perimenopausal syndrome). LA demonstrates efficacy comparable to traditional needle acupuncture in improving subjective and objective sleep quality, while also reducing affective symptoms and enhancing quality of life. This provides an appealing alternative for needle-phobia patients. LA appears generally safe, with only mild, transient adverse effects reported. Mechanistic investigations suggest that LA may act via neurotransmitter modulation, autonomic nervous system regulation, and alterations in brain wave activity. However, methodological limitations –– particularly small sample sizes, heterogeneous populations, incomplete treatment parameter reporting, and insufficient follow-ups –– compromise the current evidence base. Future research should adopt multicenter, large-scale, placebo-controlled randomized trials, complemented by advanced techniques such as neuroimaging, polysomnography, and neurochemical assays, to further validate the therapeutic potential of LA and elucidate its underlying mechanisms.
Keywords: traditional Chinese medicine, non-pharmacological treatment, auricular therapy, auriculotherapy, sleep disorder, sleep disturbance
1Department of Nursing, School of International Medical Technology, Shanghai Sanda University, Shanghai, 201209, People’s Republic of China; 2School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC, 3083, Australia; 3Sydney School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, 2050, Australia; 4Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200071, People’s Republic of China; 5Sleep Research Group, Charles Perkins Centre, The University of Sydney, Camperdown, NSW, 2050, Australia; 6School of Computing Technologies, RMIT University, Melbourne, VIC, 3000, Australia; 7School of Nursing, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, People’s Republic of China; 8Yangpu Hospital, School of Medicine, Tongji University, Shanghai, 200090, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yuen-Shan Ho, School of Nursing, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, People’s Republic of China, Tel +852 2766-6410, Fax +852 2364-9663, Email janice.ys.ho@polyu.edu.hk Qiang-Qiang Fu, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, 200090, People’s Republic of China, Tel + 86 021-6569 0520, Fax + 86 021-6569 6249, Email qiangqiang.fu@tongji.edu.cn
Abstract: Insomnia constitutes a significant worldwide public health burden. Limitations of conventional treatments, such as cognitive-behavioral therapy and hypnotic medications, have fueled growing interest in complementary and alternative medicine approaches, including laser acupuncture (LA). This comprehensive mini-review evaluates LA’s effects and mechanisms for insomnia management. Clinical evidence indicates that LA alleviates both primary insomnia and comorbid cases (eg, with cancer, hypertension, and perimenopausal syndrome). LA demonstrates efficacy comparable to traditional needle acupuncture in improving subjective and objective sleep quality, while also reducing affective symptoms and enhancing quality of life. This provides an appealing alternative for needle-phobia patients. LA appears generally safe, with only mild, transient adverse effects reported. Mechanistic investigations suggest that LA may act via neurotransmitter modulation, autonomic nervous system regulation, and alterations in brain wave activity. However, methodological limitations –– particularly small sample sizes, heterogeneous populations, incomplete treatment parameter reporting, and insufficient follow-ups –– compromise the current evidence base. Future research should adopt multicenter, large-scale, placebo-controlled randomized trials, complemented by advanced techniques such as neuroimaging, polysomnography, and neurochemical assays, to further validate the therapeutic potential of LA and elucidate its underlying mechanisms.
Keywords: traditional Chinese medicine, non-pharmacological treatment, auricular therapy, auriculotherapy, sleep disorder, sleep disturbance