111614
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
芍药甘草汤纳米制剂对芍药苷生物利用度的比较评价
Authors Shen C, Wei X, Du C, Zhang S, Zhang N, Yue P, Shen B
Received 3 June 2025
Accepted for publication 23 November 2025
Published 2 December 2025 Volume 2025:20 Pages 14313—14328
DOI https://doi.org/10.2147/IJN.S544429
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 5
Editor who approved publication: Dr Xing Zhang
Chengying Shen,1 Xinling Wei,1,2 Chaoying Du,1 Shuangchen Zhang,2,3 Nianzhan Zhang,2,3 Pengfei Yue,2,3 Baode Shen2,3
1Department of Pharmacy, Jiangxi Provincial People’s Hospital, the First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, 330006, People’s Republic of China; 2Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, 330004, People’s Republic of China; 3State Key Laboratory for the Modernization of Classical and Famous Prescriptions of Chinese Medicine, Nanchang, Jiangxi, 330004, People’s Republic of China
Correspondence: Pengfei Yue, Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, 330004, People’s Republic of China, Email ypfpharm@126.com Baode Shen, Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, 330004, People’s Republic of China, Email shenbaode@163.com
Purpose: The present study aimed to systematically compare the in vitro and in vivo characteristics of three nano-assemblies with different components derived from Shaoyao Gancao Decoction (SGD), with particular emphasis on their differential effects on oral absorption of paeoniflorin (Pae).
Methods: The self-assembled nanoparticles of SGD (SGD-SAN), glycyrrhizic acid self-assembled nanomicelles (GL-SNM), and Glycyrrhiza protein self-assembled nanoparticles (GP-SAN) were separated or prepared, and characterized in terms of particle size, zeta potential, morphology, drug loading, and in vitro release behavior. The single-pass intestinal perfusion and pharmacokinetic studies of SGD-SAN, GL-SNM, and GP-SAN following oral administration were performed to evaluate their absorption-enhancing effect. Chemical interference agents (NaCl, urea, and Tween 20) were added, followed by particle size detection, to identify the types of intermolecular forces in the self-assemblies.
Results: Three nano-assemblies exhibited significant differences in particle size (133 nm for SGD-SAN, 154 nm for GL-SNM, and 184 nm for GP-SAN) and drug loading (5.54% for SGD-SAN, 10.70% for Pae GL-SNM, and 21.52% for Pae GP-SAN). While hydrophobic interactions act as the common core force driving the formation of all nano-assemblies, their dependencies on other intermolecular forces vary remarkably. SGD-SAN, GL-SNM, and GP-SAN exhibited sustained Pae release (50– 75% over 12 h vs 100% for the Pae solution in 2 h). In situ intestinal perfusion in rats showed significantly higher effective permeability coefficients (Peff) for all nano-assemblies than the Pae solution, with GP-SAN exhibiting the highest ileal absorption, which may be attributed to preferential M-cell uptake facilitated by its protein-rich composition. Pharmacokinetic studies confirmed superior performance of GP-SAN with the highest AUC0-t (11209.01 ± 2093.72 ng/mL·h) and Cmax (2896.04 ± 255.01 ng/mL), representing 2.0-fold and 3.0-fold increases over Pae solution (5676.14 ± 311.61 ng/mL·h & 964.89 ± 128.81 ng/mL), respectively. GL-SNM and SGD-SAN also significantly enhanced the bioavailability (AUC0-t increased by 65% and 45%, respectively).
Conclusion: These results suggested that nano-assemblies, particularly protein-based GP-SAN, provide a structural foundation for SGD’s bioavailability-enhancing effect.
Keywords: shaoyao gancao decoction, nano assembly, oral absorption, paeoniflorin
1Department of Pharmacy, Jiangxi Provincial People’s Hospital, the First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, 330006, People’s Republic of China; 2Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, 330004, People’s Republic of China; 3State Key Laboratory for the Modernization of Classical and Famous Prescriptions of Chinese Medicine, Nanchang, Jiangxi, 330004, People’s Republic of China
Correspondence: Pengfei Yue, Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, 330004, People’s Republic of China, Email ypfpharm@126.com Baode Shen, Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, 330004, People’s Republic of China, Email shenbaode@163.com
Purpose: The present study aimed to systematically compare the in vitro and in vivo characteristics of three nano-assemblies with different components derived from Shaoyao Gancao Decoction (SGD), with particular emphasis on their differential effects on oral absorption of paeoniflorin (Pae).
Methods: The self-assembled nanoparticles of SGD (SGD-SAN), glycyrrhizic acid self-assembled nanomicelles (GL-SNM), and Glycyrrhiza protein self-assembled nanoparticles (GP-SAN) were separated or prepared, and characterized in terms of particle size, zeta potential, morphology, drug loading, and in vitro release behavior. The single-pass intestinal perfusion and pharmacokinetic studies of SGD-SAN, GL-SNM, and GP-SAN following oral administration were performed to evaluate their absorption-enhancing effect. Chemical interference agents (NaCl, urea, and Tween 20) were added, followed by particle size detection, to identify the types of intermolecular forces in the self-assemblies.
Results: Three nano-assemblies exhibited significant differences in particle size (133 nm for SGD-SAN, 154 nm for GL-SNM, and 184 nm for GP-SAN) and drug loading (5.54% for SGD-SAN, 10.70% for Pae GL-SNM, and 21.52% for Pae GP-SAN). While hydrophobic interactions act as the common core force driving the formation of all nano-assemblies, their dependencies on other intermolecular forces vary remarkably. SGD-SAN, GL-SNM, and GP-SAN exhibited sustained Pae release (50– 75% over 12 h vs 100% for the Pae solution in 2 h). In situ intestinal perfusion in rats showed significantly higher effective permeability coefficients (Peff) for all nano-assemblies than the Pae solution, with GP-SAN exhibiting the highest ileal absorption, which may be attributed to preferential M-cell uptake facilitated by its protein-rich composition. Pharmacokinetic studies confirmed superior performance of GP-SAN with the highest AUC0-t (11209.01 ± 2093.72 ng/mL·h) and Cmax (2896.04 ± 255.01 ng/mL), representing 2.0-fold and 3.0-fold increases over Pae solution (5676.14 ± 311.61 ng/mL·h & 964.89 ± 128.81 ng/mL), respectively. GL-SNM and SGD-SAN also significantly enhanced the bioavailability (AUC0-t increased by 65% and 45%, respectively).
Conclusion: These results suggested that nano-assemblies, particularly protein-based GP-SAN, provide a structural foundation for SGD’s bioavailability-enhancing effect.
Keywords: shaoyao gancao decoction, nano assembly, oral absorption, paeoniflorin