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已发表论文
天然产物的抗焦虑作用：病理机制、分子靶点及治疗前景
Authors Yu X, Li G, Liu J, Chen Y, Wang F
Received 1 October 2025
Accepted for publication 19 November 2025
Published 29 November 2025 Volume 2025:21 Pages 2623—2653
DOI https://doi.org/10.2147/NDT.S571692
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Roger Pinder
Xiaowen Yu,1 Guoqiang Li,2 Juan Liu,3 Yinling Chen,4 Feng Wang4
1Division 4 of Neurology Department, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, People’s Republic of China; 2Department of Pain Medicine, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, People’s Republic of China; 3Department of Traditional Chinese Medicine, Shandong Rehabilitation Hospital, Jinan, People’s Republic of China; 4Department of Neurology, Shandong Second Provincial General Hospital, Jinan, People’s Republic of China
Correspondence: Feng Wang, Email wangminfeng1989@163.com
Abstract: Anxiety disorders are complex neuropsychiatric conditions with incompletely understood mechanisms, which hinders the development of targeted therapies. Natural products have attracted attention as promising anxiolytic candidates due to their multi-component nature, synergistic effects, and ability to modulate multiple molecular targets and signaling pathways. However, a systematic integration of anxiety pathology with the mechanisms of natural products is still lacking. This review summarizes recent advances in the molecular and cellular basis of anxiety and explores how natural products (such as flavonoids, terpenoids, and alkaloids) interact with key genes, receptors, and intracellular signaling pathways. It also addresses current research limitations, including insufficient depth of mechanistic studies, lack of standardized models, and challenges in clinical translation. By synthesizing mechanistic and therapeutic evidence, this work aims to support the development of effective, evidence-based natural anxiolytics with improved clinical applicability.
Keywords: anxiety disorder, pathological mechanism, natural product, anxiolytic, clinical translation
1Division 4 of Neurology Department, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, People’s Republic of China; 2Department of Pain Medicine, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, People’s Republic of China; 3Department of Traditional Chinese Medicine, Shandong Rehabilitation Hospital, Jinan, People’s Republic of China; 4Department of Neurology, Shandong Second Provincial General Hospital, Jinan, People’s Republic of China
Correspondence: Feng Wang, Email wangminfeng1989@163.com
Abstract: Anxiety disorders are complex neuropsychiatric conditions with incompletely understood mechanisms, which hinders the development of targeted therapies. Natural products have attracted attention as promising anxiolytic candidates due to their multi-component nature, synergistic effects, and ability to modulate multiple molecular targets and signaling pathways. However, a systematic integration of anxiety pathology with the mechanisms of natural products is still lacking. This review summarizes recent advances in the molecular and cellular basis of anxiety and explores how natural products (such as flavonoids, terpenoids, and alkaloids) interact with key genes, receptors, and intracellular signaling pathways. It also addresses current research limitations, including insufficient depth of mechanistic studies, lack of standardized models, and challenges in clinical translation. By synthesizing mechanistic and therapeutic evidence, this work aims to support the development of effective, evidence-based natural anxiolytics with improved clinical applicability.
Keywords: anxiety disorder, pathological mechanism, natural product, anxiolytic, clinical translation