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已发表论文
溃疡性结肠炎炎症指标与疾病活动度相关性研究
Authors Chenfei Z, Ainiwaer Z, Xiaoling H
Received 9 July 2025
Accepted for publication 19 November 2025
Published 29 November 2025 Volume 2025:18 Pages 7143—7152
DOI https://doi.org/10.2147/IJGM.S552515
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Prof. Dr. Gopal Krishna Dhali
Zhang Chenfei, Zubiyan Ainiwaer, Huang Xiaoling
Xinjiang Uygur Autonomous Region People’s Hospital, Urumqi, Xinjiang Uygur Autonomous Region, People’s Republic of China
Correspondence: Huang Xiaoling, Email huangxiaolingzyf@sina.com
Objective: To analyze the level of systemic immune-inflammatory index (SII) in patients with ulcerative colitis (UC) and assess its relationship with disease activity.
Methods: This study included 616 UC patients and 211 healthy controls. Disease activity was assessed using the modified Mayo score, categorizing patients into remission (n=115) and active (n=501) groups, with the latter further stratified into mild, moderate, and severe activity. We compared multiple inflammatory indices—including SII, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), neutrophil percentage-albumin ratio (NPAR), and others—between groups. Spearman correlation and ROC curve analyses were used to evaluate their associations with disease activity and predictive value for active and severe UC.
Results: SII, NLR, PLR, NPAR, and several other indices were significantly higher in the UC group than controls, while lymphocyte-to-monocyte ratio (LMR) and LHR were lower (all P< 0.05). Most indices were also elevated in active versus remission UC (P< 0.05), and showed significant differences across severity subgroups (P< 0.05), with SII, NLR, NPAR, NHR, and MHR increasing with severity. Spearman analysis revealed positive correlations between these markers and disease activity/severity (P< 0.001). ROC analysis demonstrated significant predictive value for active and severe UC (AUC> 0.60, P< 0.001), with NPAR exhibiting the highest efficacy (AUC=0.854).
Conclusion: SII, NLR, PLR, NPAR, and other inflammatory indices are useful non-invasive biomarkers for assessing UC disease activity and severity, with NPAR showing the strongest predictive performance.
Keywords: ulcerative colitis, systemic immune-inflammatory index, disease activity, biomarkers
Xinjiang Uygur Autonomous Region People’s Hospital, Urumqi, Xinjiang Uygur Autonomous Region, People’s Republic of China
Correspondence: Huang Xiaoling, Email huangxiaolingzyf@sina.com
Objective: To analyze the level of systemic immune-inflammatory index (SII) in patients with ulcerative colitis (UC) and assess its relationship with disease activity.
Methods: This study included 616 UC patients and 211 healthy controls. Disease activity was assessed using the modified Mayo score, categorizing patients into remission (n=115) and active (n=501) groups, with the latter further stratified into mild, moderate, and severe activity. We compared multiple inflammatory indices—including SII, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), neutrophil percentage-albumin ratio (NPAR), and others—between groups. Spearman correlation and ROC curve analyses were used to evaluate their associations with disease activity and predictive value for active and severe UC.
Results: SII, NLR, PLR, NPAR, and several other indices were significantly higher in the UC group than controls, while lymphocyte-to-monocyte ratio (LMR) and LHR were lower (all P< 0.05). Most indices were also elevated in active versus remission UC (P< 0.05), and showed significant differences across severity subgroups (P< 0.05), with SII, NLR, NPAR, NHR, and MHR increasing with severity. Spearman analysis revealed positive correlations between these markers and disease activity/severity (P< 0.001). ROC analysis demonstrated significant predictive value for active and severe UC (AUC> 0.60, P< 0.001), with NPAR exhibiting the highest efficacy (AUC=0.854).
Conclusion: SII, NLR, PLR, NPAR, and other inflammatory indices are useful non-invasive biomarkers for assessing UC disease activity and severity, with NPAR showing the strongest predictive performance.
Keywords: ulcerative colitis, systemic immune-inflammatory index, disease activity, biomarkers