111614
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
苯扎氯铵所致颗粒状角化不全的临床特征：一项回顾性病例系列研究
Authors Lin F , Wang Y, Chen S
Received 8 September 2025
Accepted for publication 8 December 2025
Published 12 December 2025 Volume 2025:18 Pages 3373—3380
DOI https://doi.org/10.2147/CCID.S558977
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Monica K. Li
Fan Lin,* Yingwei Wang,* Shisheng Chen
Department of Dermatology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Shisheng Chen, Email 13587644163@163.com
Background: Granular parakeratosis (GP) is a rare keratinization disorder. Recent studies have suggested a possible association with exogenous irritants such as benzalkonium chloride (BAK); however, the clinical features of related cases have not yet been systematically characterized.
Aim: To analyze the clinical features, histopathological findings, and treatment outcomes of patients with GP induced by BAK exposure, with the aim of enhancing clinical recognition and management of this etiological subtype of GP.
Methods: A single-center retrospective study was conducted on eight patients diagnosed with BAK-associated GP confirmed both clinically and histopathologically, who presented between June 2024 and June 2025. Demographic data, clinical manifestations, histopathological changes, and treatment outcomes were collected and analyzed.
Results: Among the eight patients, six were male, with ages ranging from 4 to 43 years; four were children. Lesions were primarily distributed over the groin, trunk, neck, and upper chest, all presenting as erythematous-brown patches with characteristic parchment-like scaling. Histopathological examination in all cases revealed parakeratosis and retention of basophilic granules within the stratum corneum. Following definitive diagnosis and cessation of BAK exposure, combined with the use of emollients, complete resolution of lesions was achieved within 2 weeks to 1 month.
Conclusion: BAK can induce GP, which presents with certain characteristic features, notably the presence of parchment-like scaling that serves as a valuable clue for differential diagnosis. Early identification and elimination of the causative irritant are key to effective treatment. Pediatric patients may be more susceptible, and the development of GP may be related to individual predisposition and cumulative BAK exposure, warranting further investigation.
Keywords: granular parakeratosis, clinical characteristics, benzalkonium chloride
Department of Dermatology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Shisheng Chen, Email 13587644163@163.com
Background: Granular parakeratosis (GP) is a rare keratinization disorder. Recent studies have suggested a possible association with exogenous irritants such as benzalkonium chloride (BAK); however, the clinical features of related cases have not yet been systematically characterized.
Aim: To analyze the clinical features, histopathological findings, and treatment outcomes of patients with GP induced by BAK exposure, with the aim of enhancing clinical recognition and management of this etiological subtype of GP.
Methods: A single-center retrospective study was conducted on eight patients diagnosed with BAK-associated GP confirmed both clinically and histopathologically, who presented between June 2024 and June 2025. Demographic data, clinical manifestations, histopathological changes, and treatment outcomes were collected and analyzed.
Results: Among the eight patients, six were male, with ages ranging from 4 to 43 years; four were children. Lesions were primarily distributed over the groin, trunk, neck, and upper chest, all presenting as erythematous-brown patches with characteristic parchment-like scaling. Histopathological examination in all cases revealed parakeratosis and retention of basophilic granules within the stratum corneum. Following definitive diagnosis and cessation of BAK exposure, combined with the use of emollients, complete resolution of lesions was achieved within 2 weeks to 1 month.
Conclusion: BAK can induce GP, which presents with certain characteristic features, notably the presence of parchment-like scaling that serves as a valuable clue for differential diagnosis. Early identification and elimination of the causative irritant are key to effective treatment. Pediatric patients may be more susceptible, and the development of GP may be related to individual predisposition and cumulative BAK exposure, warranting further investigation.
Keywords: granular parakeratosis, clinical characteristics, benzalkonium chloride