111614
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
不同晶状体悬韧带松弛程度的急性原发性闭角型青光眼的眼部生物测量参数
Authors Wang Q , Wang X , Huang B, Liu Y, Zhang S, Lu H
Received 6 August 2025
Accepted for publication 19 November 2025
Published 10 December 2025 Volume 2025:18 Pages 7425—7432
DOI https://doi.org/10.2147/IJGM.S558791
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Brian C. Gilger
Qian Wang,1 Xinyu Wang,2 Bingyao Huang,1 Yanjing Liu,1 Shengnan Zhang,1 Hui Lu1
1Department of Ophthalmology, Zibo Central Hospital, Zibo, Shandong, 255000, People’s Republic of China; 2Shandong Second Medical University, Weifang, Shandong, 261053, People’s Republic of China
Correspondence: Hui Lu, Department of Ophthalmology, Zibo Central Hospital, Zibo, Shandong, 255000, People’s Republic of China, Tel +86-18678187916, Email xhlu1@126.com
Background: Acute primary angle closure (APAC) is a leading cause of irreversible blindness. Recent studies suggest lens zonular laxity plays a critical role in APAC pathogenesis, though its clinical detection remains challenging due to overlapping symptoms with cataract. This study investigates the prevalence of subclinical zonular degeneration in APAC patients and its correlation with ocular biometric parameters.
Methods: This retrospective cohort study included 65 APAC patients (mean age 62.3 ± 8.7 years) undergoing phacoemulsification at Zibo Central Hospital (November 2021–May 2023). Patients were stratified into three groups based on intraoperative zonular status: normal zonula (APAC-NZ, n=14), mild zonular laxity (APAC-ZL, n=39), and significant zonular laxity (APAC-SZL, n=12). Preoperative axial length (AL), lens thickness (LT), and anterior chamber depth (ACD) were measured using IOLMaster 5.0 and swept-source UBM.
Results: A high prevalence (78.5%, 51/65) of undiagnosed zonular degeneration was observed. Significant differences were found in sitting ACD (2.25 ± 0.17 mm vs 1.75 ± 0.19 mm), supine ACD (1.72 ± 0.11 mm vs 1.27 ± 0.12 mm), and LT (5.10 ± 0.28 mm vs 5.41 ± 0.38 mm) between APAC-NZ and APAC-SZL groups (P< 0.05). Similar differences were noted between APAC-SZL and APAC-ZL groups (P< 0.05).
Conclusion: This study introduces a novel stratification of APAC patients by zonular laxity severity and reveals distinct biometric profiles across subgroups. We demonstrate a high prevalence of undiagnosed zonulopathy in APAC patients, associated with thicker lenses and shallower anterior chambers. A key limitation is the subjective classification of zonular laxity, based solely on intraoperative observations. Future studies should develop objective imaging protocols for improved detection and management.
Keywords: acute primary angle closure, zonular laxity, axial length, lens thickness, anterior chamber depth
1Department of Ophthalmology, Zibo Central Hospital, Zibo, Shandong, 255000, People’s Republic of China; 2Shandong Second Medical University, Weifang, Shandong, 261053, People’s Republic of China
Correspondence: Hui Lu, Department of Ophthalmology, Zibo Central Hospital, Zibo, Shandong, 255000, People’s Republic of China, Tel +86-18678187916, Email xhlu1@126.com
Background: Acute primary angle closure (APAC) is a leading cause of irreversible blindness. Recent studies suggest lens zonular laxity plays a critical role in APAC pathogenesis, though its clinical detection remains challenging due to overlapping symptoms with cataract. This study investigates the prevalence of subclinical zonular degeneration in APAC patients and its correlation with ocular biometric parameters.
Methods: This retrospective cohort study included 65 APAC patients (mean age 62.3 ± 8.7 years) undergoing phacoemulsification at Zibo Central Hospital (November 2021–May 2023). Patients were stratified into three groups based on intraoperative zonular status: normal zonula (APAC-NZ, n=14), mild zonular laxity (APAC-ZL, n=39), and significant zonular laxity (APAC-SZL, n=12). Preoperative axial length (AL), lens thickness (LT), and anterior chamber depth (ACD) were measured using IOLMaster 5.0 and swept-source UBM.
Results: A high prevalence (78.5%, 51/65) of undiagnosed zonular degeneration was observed. Significant differences were found in sitting ACD (2.25 ± 0.17 mm vs 1.75 ± 0.19 mm), supine ACD (1.72 ± 0.11 mm vs 1.27 ± 0.12 mm), and LT (5.10 ± 0.28 mm vs 5.41 ± 0.38 mm) between APAC-NZ and APAC-SZL groups (P< 0.05). Similar differences were noted between APAC-SZL and APAC-ZL groups (P< 0.05).
Conclusion: This study introduces a novel stratification of APAC patients by zonular laxity severity and reveals distinct biometric profiles across subgroups. We demonstrate a high prevalence of undiagnosed zonulopathy in APAC patients, associated with thicker lenses and shallower anterior chambers. A key limitation is the subjective classification of zonular laxity, based solely on intraoperative observations. Future studies should develop objective imaging protocols for improved detection and management.
Keywords: acute primary angle closure, zonular laxity, axial length, lens thickness, anterior chamber depth