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已发表论文
1 型发作性睡病患者血脂异常的血清代谢组学特征：一项多中心横断面研究
Authors Wu J , Dai Y, Xu L , Zhang J, Chen L , Zheng D, Chen B , Han F , Li Y
Received 3 September 2025
Accepted for publication 24 November 2025
Published 10 December 2025 Volume 2025:17 Pages 3115—3126
DOI https://doi.org/10.2147/NSS.S561105
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Sarah L Appleton
Jun Wu,1– 4 Yanyuan Dai,1– 4 Liyue Xu,5 Jiansheng Zhang,1– 4 Le Chen,1– 4 Dandan Zheng,1– 4 Baixin Chen,1– 4 Fang Han,5 Yun Li1– 4
1Department of Sleep Medicine, Mental Health Center of Shantou University, Shantou University Medical College, Shantou, Guangdong, People’s Republic of China; 2Sleep Medicine Center, Shantou University Medical College, Shantou, Guangdong, People’s Republic of China; 3Shantou University Medical College - Faculty of Medicine of University of Manitoba Joint Laboratory of Biological Psychiatry Shantou Guangdong People’s Republic of China; 4Shantou Key Laboratory of Multimodal Mechanisms and Clinical Diagnosis and Treatment of Sleep Disorders, Shantou, Guangdong, People’s Republic of China; 5Division of Sleep Medicine, Peking University People’s Hospital, Beijing, People’s Republic of China
Correspondence: Yun Li, Department of Sleep Medicine, Mental Health Center of Shantou University, Shantou University Medical College, North Taishan Road, Wanji District, Shantou, Guangdong Province, 515041, People’s Republic of China, Email s_liyun@stu.edu.cn
Study Objectives: We aimed to explore the candidate metabolic pathways involved in narcolepsy type 1 (NT1)-related dyslipidemia.
Methods: Forty-four patients with NT1, and 44 controls were included in this multicenter metabolomics study. All participants included underwent an overnight polysomnography and multiple sleep latency test. Fasting blood samples were collected to assess lipid levels, including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglyceride (TG). Serum metabolomics was used to explore characteristic metabolites in the discovery and validation sets.
Results: Patients with NT1 had higher values for TC (5.13 ± 0.14 vs 4.63 ± 0.14 mmol/L, P = 0.024), and LDL-C (3.01± 0.13 vs 2.59 ± 0.13 mmol/L, P = 0.038), but a lower HDL-C (1.32 ± 0.07 vs 1.53 ± 0.07 mmol/L, P = 0.039) compared to controls after adjusting for potential confounders. Enrichment analysis suggested that arginine biosynthesis and arginine and proline metabolism were different between patients with NT1 and controls. Four NT1-related metabolites were identified, glutamate (β = − 0.319, P = 0.049) correlated negatively with HDL-C, after adjusting for potential confounders.
Conclusion: Increased serum glutamate level is associated with decreased level of HDL-C in patients with NT1. Arginine metabolism dysfunction may contribute to dyslipidemia in NT1.
Keywords: narcolepsy type 1, dyslipidemia, serum metabolomics, arginine metabolism, high-density lipoprotein cholesterol
1Department of Sleep Medicine, Mental Health Center of Shantou University, Shantou University Medical College, Shantou, Guangdong, People’s Republic of China; 2Sleep Medicine Center, Shantou University Medical College, Shantou, Guangdong, People’s Republic of China; 3Shantou University Medical College - Faculty of Medicine of University of Manitoba Joint Laboratory of Biological Psychiatry Shantou Guangdong People’s Republic of China; 4Shantou Key Laboratory of Multimodal Mechanisms and Clinical Diagnosis and Treatment of Sleep Disorders, Shantou, Guangdong, People’s Republic of China; 5Division of Sleep Medicine, Peking University People’s Hospital, Beijing, People’s Republic of China
Correspondence: Yun Li, Department of Sleep Medicine, Mental Health Center of Shantou University, Shantou University Medical College, North Taishan Road, Wanji District, Shantou, Guangdong Province, 515041, People’s Republic of China, Email s_liyun@stu.edu.cn
Study Objectives: We aimed to explore the candidate metabolic pathways involved in narcolepsy type 1 (NT1)-related dyslipidemia.
Methods: Forty-four patients with NT1, and 44 controls were included in this multicenter metabolomics study. All participants included underwent an overnight polysomnography and multiple sleep latency test. Fasting blood samples were collected to assess lipid levels, including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglyceride (TG). Serum metabolomics was used to explore characteristic metabolites in the discovery and validation sets.
Results: Patients with NT1 had higher values for TC (5.13 ± 0.14 vs 4.63 ± 0.14 mmol/L, P = 0.024), and LDL-C (3.01± 0.13 vs 2.59 ± 0.13 mmol/L, P = 0.038), but a lower HDL-C (1.32 ± 0.07 vs 1.53 ± 0.07 mmol/L, P = 0.039) compared to controls after adjusting for potential confounders. Enrichment analysis suggested that arginine biosynthesis and arginine and proline metabolism were different between patients with NT1 and controls. Four NT1-related metabolites were identified, glutamate (β = − 0.319, P = 0.049) correlated negatively with HDL-C, after adjusting for potential confounders.
Conclusion: Increased serum glutamate level is associated with decreased level of HDL-C in patients with NT1. Arginine metabolism dysfunction may contribute to dyslipidemia in NT1.
Keywords: narcolepsy type 1, dyslipidemia, serum metabolomics, arginine metabolism, high-density lipoprotein cholesterol