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已发表论文
年龄、TNM 分期及住院情况对膀胱癌患者生存的影响：来自中国东部一家医院队列的证据
Authors Lu LL, Chen HZ, Chen JG
Received 17 September 2025
Accepted for publication 20 November 2025
Published 6 December 2025 Volume 2025:17 Pages 481—493
DOI https://doi.org/10.2147/RRU.S568396
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Panagiotis J Vlachostergios
Ling-Ling Lu,1,* Hai-Zhen Chen,2,* Jian-Guo Chen1
1Department of Epidemiology, Qidong Liver Cancer Institute, Qidong People’s Hospital, Affiliated Qidong Hospital of Nantong University, Qidong, Jiangsu, 226200, People’s Republic of China; 2Department of Epidemiology, Nantong Tumor Hospital, Affiliated Tumor Hospital of Nantong University, Nantong, Jiangsu, 226361, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Jian-Guo Chen, Department of Epidemiology, Qidong Liver Cancer Institute, Qidong People’s Hospital, Affiliated Qidong Hospital of Nantong University, 785 Jianghai Zhong Road, Qidong, Jiangsu, 226200, People’s Republic of China, Tel +86-513-83346201, Email chenjg@ntu.edu.cn
Purpose: To evaluate survival outcomes and identify prognostic factors among bladder cancer patients.
Patients and Methods: A total of 488 bladder cancer patients admitted between 2007 and 2017 were followed until December 31, 2020, using both active and passive follow-up. The Kaplan-Meier method was used to estimate observed survival (OS), with group comparisons performed using the Log rank test. Variables included sex, age group, number of hospital admissions, TNM stage, and geographic origin.
Results: Of 488 patients, 485 (99.38%) were successfully followed. The majority were male (80.21%) with a mean age of 66.5 years. The average number of hospital admissions was 1.81. Overall 1-, 3-, 5-, and 10-year OS rates were 79.95%, 63.50%, 56.32%, and 45.54% for males, and 69.79%, 58.33%, 56.01%, and 56.01% for females, respectively (P = 0.697). Age significantly affected prognosis (P < 0.01), with 5-year OS declining from 66.67% (age ≤ 34) to 29.53% (≥ 80). Patients with ≥ 3 admissions had worse survival (44.87%) than those with one (61.93%) or two admissions (58.97%) (P < 0.01). TNM stage was strongly with survival: 5-year OS rates were 86.43% (Stage I), 55.48% (Stage II), 38.25% (Stage III), and 13.85% (Stage IV) (P < 0.01). Regional differences were not statistically significant (P > 0.05).
Conclusion: Advanced age and late-stage diagnosis were associated with poorer survival, while early-stage detection correlated with better outcomes. These findings underscore the importance of early screening, timely treatment, and comprehensive care strategies to improve bladder cancer survival, especially in resource-limited settings. Limitations include single-center design and absence of multivariate adjustment.
Keywords: cancer registry, follow-up, Kaplan-Meier, prognostic factors
1Department of Epidemiology, Qidong Liver Cancer Institute, Qidong People’s Hospital, Affiliated Qidong Hospital of Nantong University, Qidong, Jiangsu, 226200, People’s Republic of China; 2Department of Epidemiology, Nantong Tumor Hospital, Affiliated Tumor Hospital of Nantong University, Nantong, Jiangsu, 226361, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Jian-Guo Chen, Department of Epidemiology, Qidong Liver Cancer Institute, Qidong People’s Hospital, Affiliated Qidong Hospital of Nantong University, 785 Jianghai Zhong Road, Qidong, Jiangsu, 226200, People’s Republic of China, Tel +86-513-83346201, Email chenjg@ntu.edu.cn
Purpose: To evaluate survival outcomes and identify prognostic factors among bladder cancer patients.
Patients and Methods: A total of 488 bladder cancer patients admitted between 2007 and 2017 were followed until December 31, 2020, using both active and passive follow-up. The Kaplan-Meier method was used to estimate observed survival (OS), with group comparisons performed using the Log rank test. Variables included sex, age group, number of hospital admissions, TNM stage, and geographic origin.
Results: Of 488 patients, 485 (99.38%) were successfully followed. The majority were male (80.21%) with a mean age of 66.5 years. The average number of hospital admissions was 1.81. Overall 1-, 3-, 5-, and 10-year OS rates were 79.95%, 63.50%, 56.32%, and 45.54% for males, and 69.79%, 58.33%, 56.01%, and 56.01% for females, respectively (P = 0.697). Age significantly affected prognosis (P < 0.01), with 5-year OS declining from 66.67% (age ≤ 34) to 29.53% (≥ 80). Patients with ≥ 3 admissions had worse survival (44.87%) than those with one (61.93%) or two admissions (58.97%) (P < 0.01). TNM stage was strongly with survival: 5-year OS rates were 86.43% (Stage I), 55.48% (Stage II), 38.25% (Stage III), and 13.85% (Stage IV) (P < 0.01). Regional differences were not statistically significant (P > 0.05).
Conclusion: Advanced age and late-stage diagnosis were associated with poorer survival, while early-stage detection correlated with better outcomes. These findings underscore the importance of early screening, timely treatment, and comprehensive care strategies to improve bladder cancer survival, especially in resource-limited settings. Limitations include single-center design and absence of multivariate adjustment.
Keywords: cancer registry, follow-up, Kaplan-Meier, prognostic factors