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已发表论文
抑郁症与带状疱疹或带状疱疹后神经痛之间无因果关联的证据：一项孟德尔随机化研究
Authors Zhang X , Chen Y , Lin J, Guo W, Zhou H, Yang X, Zhao Q
Received 12 July 2025
Accepted for publication 26 November 2025
Published 6 December 2025 Volume 2025:18 Pages 6579—6589
DOI https://doi.org/10.2147/JPR.S553378
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Professor King Hei Stanley Lam
Xuerong Zhang,* Yuqing Chen,* Jingrun Lin,* Weibing Guo, Hongchun Zhou, Xueying Yang, Qiong Zhao
Department of Anesthesiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Qiong Zhao, Department of Anesthesiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, 510120, People’s Republic of China, Tel +86-177-2425-0727, Email zhaoq53@mail.sysu.edu.cn Xueying Yang, Department of Anesthesiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, 510120, People’s Republic of China, Tel +86-188-0204-0810, Email yangxy83@mail.sysu.edu.cn
Background: Observational studies have suggested a correlation between depression and herpes zoster (HZ), as well as post-herpetic neuralgia (PHN); however, the causal relationship remains unclear. This study aimed to assess the causal relationships between depression and HZ and PHN via a two-sample bidirectional Mendelian randomization (MR) approach.
Methods: We collected data for major depressive disorder (MDD, 246,363 cases/561,190 controls), depressive status (442,840 individuals), HZ (7,132 cases/480,316 controls) and PHN (490 cases/435,371 controls) from genome-wide association studies (GWASs) in European populations, along with depression-related consultations (430 cases/2,152 controls) and zoster infections (2,209 cases/166,603 controls), for validation analysis in East Asian populations. We employed inverse variance weighted (IVW), MR-Egger, weighted median, weighted mode, and MR-PRESSO for our analysis.
Results: Although suggestive, no statistically significant associations were found between genetic MDD and the risk of HZ (IVW, OR: 1.190, 95% CI: 0.984– 1.439, P=0.073) or PHN (IVW, OR: 0.820, 95% CI: 0.428– 1.570, P=0.549) in Europeans. The same was true for depressive status and HZ (IVW, OR: 1.688, 95% CI: 0.820– 3.477, P=0.155) or PHN risk (IVW, OR: 9.535, 95% CI: 0.227– 400.820, P=0.237). In East Asians, genetic depression-related consultation did not significantly affect the risk of herpes infection (IVW, OR: 0.976, 95% CI: 0.922– 1.033, P=0.401). No reverse causality was observed.
Conclusion: A comprehensive MR study suggested that depression is not causally related to susceptibility to HZ or PHN, and vice versa. Future studies should focus on how environmental/clinical, not genetic factors that cause depression affect the risk of HZ and PHN.
Keywords: depression, herpes zoster, post-herpetic neuralgia, mendelian randomization
Department of Anesthesiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Qiong Zhao, Department of Anesthesiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, 510120, People’s Republic of China, Tel +86-177-2425-0727, Email zhaoq53@mail.sysu.edu.cn Xueying Yang, Department of Anesthesiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, 510120, People’s Republic of China, Tel +86-188-0204-0810, Email yangxy83@mail.sysu.edu.cn
Background: Observational studies have suggested a correlation between depression and herpes zoster (HZ), as well as post-herpetic neuralgia (PHN); however, the causal relationship remains unclear. This study aimed to assess the causal relationships between depression and HZ and PHN via a two-sample bidirectional Mendelian randomization (MR) approach.
Methods: We collected data for major depressive disorder (MDD, 246,363 cases/561,190 controls), depressive status (442,840 individuals), HZ (7,132 cases/480,316 controls) and PHN (490 cases/435,371 controls) from genome-wide association studies (GWASs) in European populations, along with depression-related consultations (430 cases/2,152 controls) and zoster infections (2,209 cases/166,603 controls), for validation analysis in East Asian populations. We employed inverse variance weighted (IVW), MR-Egger, weighted median, weighted mode, and MR-PRESSO for our analysis.
Results: Although suggestive, no statistically significant associations were found between genetic MDD and the risk of HZ (IVW, OR: 1.190, 95% CI: 0.984– 1.439, P=0.073) or PHN (IVW, OR: 0.820, 95% CI: 0.428– 1.570, P=0.549) in Europeans. The same was true for depressive status and HZ (IVW, OR: 1.688, 95% CI: 0.820– 3.477, P=0.155) or PHN risk (IVW, OR: 9.535, 95% CI: 0.227– 400.820, P=0.237). In East Asians, genetic depression-related consultation did not significantly affect the risk of herpes infection (IVW, OR: 0.976, 95% CI: 0.922– 1.033, P=0.401). No reverse causality was observed.
Conclusion: A comprehensive MR study suggested that depression is not causally related to susceptibility to HZ or PHN, and vice versa. Future studies should focus on how environmental/clinical, not genetic factors that cause depression affect the risk of HZ and PHN.
Keywords: depression, herpes zoster, post-herpetic neuralgia, mendelian randomization