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已发表论文
迈向高质量脐带血采集：品管圈的应用
Authors Peng J, Shi CY , Kuang FY, Ma TB, Yu XB
Received 3 July 2025
Accepted for publication 19 November 2025
Published 6 December 2025 Volume 2025:16 Pages 589—599
DOI https://doi.org/10.2147/JBM.S550641
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Martin H Bluth
Jun Peng,1,2,* Cong-Ying Shi,3,* Fa-Ying Kuang,2 Tian-Bao Ma,3 Xi-Bao Yu3
1Department of Gynecology and Obstetrics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China; 2Department of Gynecology and Obstetrics, Zengcheng Branch of Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China; 3Department of Guangdong Cord Blood Bank, Guangdong Women and Children Hospital, Guangzhou, Guangdong, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Cong-Ying Shi, Department of Guangdong Cord Blood Bank, Guangdong Women and Children Hospital, Guangzhou, Guangdong, People’s Republic of China, Tel +86 13416131816, Email cyshi@chinacord.org
Purpose: All umbilical cord blood (UCB) used for hematopoietic cell transplantation (HCT) must pass through a series of strict tests, including volume, total nucleated cell count, microbial contamination, hematopoietic stem cells content, and activity. A strictly standardizing collection procedures for UCB within hospitals is a critical step in preserving hematopoietic stem cells resources.
Methods: The study included a total of 560 participants, with 337 in the control group and 223 in the observation group, collected from January 2022 to December 2024. Participants were randomly assigned to two groups. The UCB collected from newborns before the initiation of Quality Control Circle (QCC) activities served as the control group, whereas those collected after the initiation of QCC activities formed the observation group. Through the establishment of QCC nursing management, the reasons for UCB storage failures within the department were analyzed, and corresponding countermeasures were formulated. Statistical analyses were performed to compare the reasons for failure of UCB storage, success rate, and quality indicators of successfully stored UCB between the two groups.
Results: There were no statistically significant differences in the general clinical data of the newborns between the two groups. After the implementation of QCC activities, the rate of successfully stored UCB samples in the observation group was 90.6%, which was significantly higher than that of 84.3% in the control group (P=0.031). There were no statistically significant differences in the quality indicators of successfully stored UCB between the two groups.
Conclusion: The implementation of QCC in UCB collection increased the success rate by 6.3 percentage points without compromising cellular quality, supporting its application as a continuous improvement strategy in obstetric settings.
Keywords: blood banking, hematopoietic stem cells, quality improvement, umbilical cord blood
1Department of Gynecology and Obstetrics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China; 2Department of Gynecology and Obstetrics, Zengcheng Branch of Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China; 3Department of Guangdong Cord Blood Bank, Guangdong Women and Children Hospital, Guangzhou, Guangdong, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Cong-Ying Shi, Department of Guangdong Cord Blood Bank, Guangdong Women and Children Hospital, Guangzhou, Guangdong, People’s Republic of China, Tel +86 13416131816, Email cyshi@chinacord.org
Purpose: All umbilical cord blood (UCB) used for hematopoietic cell transplantation (HCT) must pass through a series of strict tests, including volume, total nucleated cell count, microbial contamination, hematopoietic stem cells content, and activity. A strictly standardizing collection procedures for UCB within hospitals is a critical step in preserving hematopoietic stem cells resources.
Methods: The study included a total of 560 participants, with 337 in the control group and 223 in the observation group, collected from January 2022 to December 2024. Participants were randomly assigned to two groups. The UCB collected from newborns before the initiation of Quality Control Circle (QCC) activities served as the control group, whereas those collected after the initiation of QCC activities formed the observation group. Through the establishment of QCC nursing management, the reasons for UCB storage failures within the department were analyzed, and corresponding countermeasures were formulated. Statistical analyses were performed to compare the reasons for failure of UCB storage, success rate, and quality indicators of successfully stored UCB between the two groups.
Results: There were no statistically significant differences in the general clinical data of the newborns between the two groups. After the implementation of QCC activities, the rate of successfully stored UCB samples in the observation group was 90.6%, which was significantly higher than that of 84.3% in the control group (P=0.031). There were no statistically significant differences in the quality indicators of successfully stored UCB between the two groups.
Conclusion: The implementation of QCC in UCB collection increased the success rate by 6.3 percentage points without compromising cellular quality, supporting its application as a continuous improvement strategy in obstetric settings.
Keywords: blood banking, hematopoietic stem cells, quality improvement, umbilical cord blood