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已发表论文
结核性、布鲁氏菌性及化脓性脊柱炎的临床特征及治疗差异：一项队列研究
Authors Shen JJ, Yao RX, Ye Y, Gao YF, Li JB , Hu LF
Received 30 August 2025
Accepted for publication 25 November 2025
Published 6 December 2025 Volume 2025:18 Pages 6377—6387
DOI https://doi.org/10.2147/IDR.S563720
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Hazrat Bilal
Jiao-Jiao Shen,1,2,* Rui-Xuan Yao,1,2,* Ying Ye,1 Yu-Feng Gao,1 Jia-Bin Li,1,2 Li-Fen Hu1,2
1Department of Infectious Diseases & Anhui Center for Surveillance of Bacterial Resistance, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, People’s Republic of China; 2Anhui Province Key Laboratory of Infectious Diseases & Institute of Bacterial Resistance, Anhui Medical University, Hefei, 230022, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Jia-Bin Li; Li-Fen Hu, Email lijiabin@ahmu.edu.cn; hulifen@ahmu.edu.cn
Purpose: There was an increasing incidence of spinal infections. This study aimed to compare and contrast the clinical characteristics and treatment regimens for diverse types of spondylitis and to provide guidance for clinicians to make timely diagnosis and treatment.
Patients and Methods: One hundred and twenty-five patients with spinal infections admitted to the First Affiliated Hospital of Anhui Medical University from October 2019 to December 2024 were recruited. The patients were classified as having tuberculous spondylitis (TBS), brucellosis spondylitis (BS), or pyogenic spondylitis (PS). The patient’s treatment regimen and course were dynamically followed up during hospitalization and after discharge. Comparisons of clinical characteristics and treatment among the three groups were performed by SPSS 26.0 and GraphPad Prism 10 statistical software.
Results: The proportion of male patients was greater than female patients (65.00% vs 35.00%). Fever accompanied by pain was more prevalent in the BS and PS groups than in the TBS group (P=0.003). Compared with the TBS and BS groups, the PS group had the shortest duration from symptom onset to hospitalization (P< 0.001). Sepsis, invasive manipulation, elevated inflammatory markers, psoas abscesses, and the involvement of three or more vertebrae were significantly associated with the PS. In this study, the median duration of treatment was 77 weeks for TBS, 19 weeks for BS, and 13 weeks for PS. Adverse drug reactions (ADRs) should be monitored during treatment. Our results indicated that omadacycline and contezolid exhibited remarkable efficacy in the treatment of spinal infections.
Conclusion: Patients of spinal infections with diverse etiologies presented varied clinical features and risk factors, the treatment should be individualized. Due to the long course of treatment, ADRs need to be monitored during treatment, and newer drugs such as omadacycline and contezolid are efficacious and have favorable safety profiles.
Keywords: spinal infectious diseases, clinical characteristics, treatment regimens, treatment durations
1Department of Infectious Diseases & Anhui Center for Surveillance of Bacterial Resistance, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, People’s Republic of China; 2Anhui Province Key Laboratory of Infectious Diseases & Institute of Bacterial Resistance, Anhui Medical University, Hefei, 230022, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Jia-Bin Li; Li-Fen Hu, Email lijiabin@ahmu.edu.cn; hulifen@ahmu.edu.cn
Purpose: There was an increasing incidence of spinal infections. This study aimed to compare and contrast the clinical characteristics and treatment regimens for diverse types of spondylitis and to provide guidance for clinicians to make timely diagnosis and treatment.
Patients and Methods: One hundred and twenty-five patients with spinal infections admitted to the First Affiliated Hospital of Anhui Medical University from October 2019 to December 2024 were recruited. The patients were classified as having tuberculous spondylitis (TBS), brucellosis spondylitis (BS), or pyogenic spondylitis (PS). The patient’s treatment regimen and course were dynamically followed up during hospitalization and after discharge. Comparisons of clinical characteristics and treatment among the three groups were performed by SPSS 26.0 and GraphPad Prism 10 statistical software.
Results: The proportion of male patients was greater than female patients (65.00% vs 35.00%). Fever accompanied by pain was more prevalent in the BS and PS groups than in the TBS group (P=0.003). Compared with the TBS and BS groups, the PS group had the shortest duration from symptom onset to hospitalization (P< 0.001). Sepsis, invasive manipulation, elevated inflammatory markers, psoas abscesses, and the involvement of three or more vertebrae were significantly associated with the PS. In this study, the median duration of treatment was 77 weeks for TBS, 19 weeks for BS, and 13 weeks for PS. Adverse drug reactions (ADRs) should be monitored during treatment. Our results indicated that omadacycline and contezolid exhibited remarkable efficacy in the treatment of spinal infections.
Conclusion: Patients of spinal infections with diverse etiologies presented varied clinical features and risk factors, the treatment should be individualized. Due to the long course of treatment, ADRs need to be monitored during treatment, and newer drugs such as omadacycline and contezolid are efficacious and have favorable safety profiles.
Keywords: spinal infectious diseases, clinical characteristics, treatment regimens, treatment durations