111536
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
维生素D不足与带状疱疹后神经痛烧灼痛的性别特异性关联：一项前瞻性队列研究
Authors Zhao W , Li Z, Ju J, Liu J, Peng X, Chu T , Ren J, Tu Y, Gao F
Received 20 July 2025
Accepted for publication 29 November 2025
Published 5 December 2025 Volume 2025:18 Pages 6515—6525
DOI https://doi.org/10.2147/JPR.S555071
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 4
Editor who approved publication: Professor King Hei Stanley Lam
Wei Zhao, Zheng Li, Jie Ju, Jie Liu, Xiaoling Peng, Tiantian Chu, Jihao Ren, Ye Tu, Feng Gao
Department of Anesthesiology and Pain Medicine, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China
Correspondence: Feng Gao, Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430000, People’s Republic of China, Tel +86 13971587381, Fax +86 27 83662853, Email fgao@tjh.tjmu.edu.cn
Purpose: Vitamin D is important for host immunity and a large proportion of herpes zoster patients experience vitamin D insufficiency (VDI). However, the role of vitamin D in herpetic neuralgia (HN) remains controversial. This study aims to explore the potential relationship between vitamin D status and HN characteristics.
Patients and methods: This prospective observational cohort study was conducted from February 2024 to November 2024 with 160 HN patients within 12 weeks after rash onset. Demographic and clinical data of patients were collected. The serum 25-hydroxyvitamin D level, triglyceride and other laboratory parameters were measured at patients’ admission. Comprehensive pain evaluations including the Brief Pain Inventory (BPI), 11-point Numerical Rating Scale (NRS) and Douleur Neuropathique 4 questionnaires were performed at admission, as well as 1, 2, and 3 months after treatment.
Results: VDI was prevalent (121 VDI, 39 VDS) in the cohort. Although no significant correlation emerged between vitamin D levels and BPI or NRS scores, Female (n = 82, odds ratio [OR] 2.80, 95% CI 1.30– 6.33, P < 0.05) and high serum triglyceride level (OR 3.20, 95% CI 1.41– 8.86, P < 0.05) were identified as independent predictors of VDI. Female patients exhibited a significant negative correlation between vitamin D status and burning pain (Spearman’s ρ = − 0.347, P < 0.001) and a concomitantly lower early pain relief rate compared to males, in whom the correlation was non-significant (n = 78, ρ = 0.7, P > 0.05).
Conclusion: Low vitamin D levels are common in HN patients. The sex-specific association between VDI and burning pain, as well as short-term prognosis, Triglyceride levels served as a predictive indicator for VDI in HN patients. Future studies are needed to elucidate the underlying mechanisms of the pain-vitamin D association specifically in female patients.
Keywords: herpetic neuralgia, vitamin D, triglyceride, burning pain
Department of Anesthesiology and Pain Medicine, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China
Correspondence: Feng Gao, Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430000, People’s Republic of China, Tel +86 13971587381, Fax +86 27 83662853, Email fgao@tjh.tjmu.edu.cn
Purpose: Vitamin D is important for host immunity and a large proportion of herpes zoster patients experience vitamin D insufficiency (VDI). However, the role of vitamin D in herpetic neuralgia (HN) remains controversial. This study aims to explore the potential relationship between vitamin D status and HN characteristics.
Patients and methods: This prospective observational cohort study was conducted from February 2024 to November 2024 with 160 HN patients within 12 weeks after rash onset. Demographic and clinical data of patients were collected. The serum 25-hydroxyvitamin D level, triglyceride and other laboratory parameters were measured at patients’ admission. Comprehensive pain evaluations including the Brief Pain Inventory (BPI), 11-point Numerical Rating Scale (NRS) and Douleur Neuropathique 4 questionnaires were performed at admission, as well as 1, 2, and 3 months after treatment.
Results: VDI was prevalent (121 VDI, 39 VDS) in the cohort. Although no significant correlation emerged between vitamin D levels and BPI or NRS scores, Female (n = 82, odds ratio [OR] 2.80, 95% CI 1.30– 6.33, P < 0.05) and high serum triglyceride level (OR 3.20, 95% CI 1.41– 8.86, P < 0.05) were identified as independent predictors of VDI. Female patients exhibited a significant negative correlation between vitamin D status and burning pain (Spearman’s ρ = − 0.347, P < 0.001) and a concomitantly lower early pain relief rate compared to males, in whom the correlation was non-significant (n = 78, ρ = 0.7, P > 0.05).
Conclusion: Low vitamin D levels are common in HN patients. The sex-specific association between VDI and burning pain, as well as short-term prognosis, Triglyceride levels served as a predictive indicator for VDI in HN patients. Future studies are needed to elucidate the underlying mechanisms of the pain-vitamin D association specifically in female patients.
Keywords: herpetic neuralgia, vitamin D, triglyceride, burning pain