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已发表论文
皮肤微生物组在健康与疾病中的作用：机制及新兴治疗策略
Authors Li Z, Zhang J, Zhang Y, Chen H, Bao Y
Received 3 October 2025
Accepted for publication 14 December 2025
Published 18 December 2025 Volume 2025:18 Pages 3443—3455
DOI https://doi.org/10.2147/CCID.S571984
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Jeffrey Weinberg
Zhouna Li,1 Jianqing Zhang,2,3 Ying Zhang,2,3 Hong Chen,2,3 Yanqiu Bao2,3
1Department of Medical Aesthetics & Plastic Surgery, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, People’s Republic of China; 2Department of Dermatology, Shaoxing People’s Hospital, Shaoxing, People’s Republic of China; 3School of Medicine, Shaoxing University, Shaoxing, People’s Republic of China
Correspondence: Yanqiu Bao, Department of Dermatology, Shaoxing People’s Hospital, 568 Zhongxing North Road, Yuecheng District, Shaoxing, Zhejiang, 312000, People’s Republic of China, Email baoyanqiu96@163.com
Abstract: The skin microbiome plays a vital role in maintaining skin homeostasis by regulating immune responses, preserving barrier integrity, and inhibiting pathogen colonization. This review systematically explores the mechanisms underlying its dysregulation in conditions such as acne, atopic dermatitis, psoriasis, and impaired wound healing, with a focus on key factors including microbial over colonization, diminished diversity, and host immune dysregulation. The influence of microbial metabolites, such as short-chain fatty acids and porphyrins, is also examined. We further evaluate emerging microbial-targeted therapeutic strategies, including live biotherapeutic products, skin microbiota transplantation, epigenetic and metabolic interventions, and precision antimicrobial polymers. These approaches aim to restore microbial balance rather than achieve broad-spectrum sterilization, representing a significant shift in the treatment paradigm for cutaneous diseases. In contrast to previous reviews, this article places special emphasis on the mechanisms of multi-organ interactions within the gut-skin axis and discusses the potential of integrating multi-omics technologies and artificial intelligence to advance the clinical translation of personalized microbial therapies, thereby providing a forward-looking perspective on the field.
Keywords: skin microbiome, skin diseases, dysbiosis, host-microbe interactions, therapeutic interventions
1Department of Medical Aesthetics & Plastic Surgery, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, People’s Republic of China; 2Department of Dermatology, Shaoxing People’s Hospital, Shaoxing, People’s Republic of China; 3School of Medicine, Shaoxing University, Shaoxing, People’s Republic of China
Correspondence: Yanqiu Bao, Department of Dermatology, Shaoxing People’s Hospital, 568 Zhongxing North Road, Yuecheng District, Shaoxing, Zhejiang, 312000, People’s Republic of China, Email baoyanqiu96@163.com
Abstract: The skin microbiome plays a vital role in maintaining skin homeostasis by regulating immune responses, preserving barrier integrity, and inhibiting pathogen colonization. This review systematically explores the mechanisms underlying its dysregulation in conditions such as acne, atopic dermatitis, psoriasis, and impaired wound healing, with a focus on key factors including microbial over colonization, diminished diversity, and host immune dysregulation. The influence of microbial metabolites, such as short-chain fatty acids and porphyrins, is also examined. We further evaluate emerging microbial-targeted therapeutic strategies, including live biotherapeutic products, skin microbiota transplantation, epigenetic and metabolic interventions, and precision antimicrobial polymers. These approaches aim to restore microbial balance rather than achieve broad-spectrum sterilization, representing a significant shift in the treatment paradigm for cutaneous diseases. In contrast to previous reviews, this article places special emphasis on the mechanisms of multi-organ interactions within the gut-skin axis and discusses the potential of integrating multi-omics technologies and artificial intelligence to advance the clinical translation of personalized microbial therapies, thereby providing a forward-looking perspective on the field.
Keywords: skin microbiome, skin diseases, dysbiosis, host-microbe interactions, therapeutic interventions