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已发表论文
空腹和餐后 ApoB48 水平与代谢综合征的相关性：一项横断面研究
Authors Tang Y, Zeng S, Hou X, Tian P, Ren L, Song G
Received 13 August 2025
Accepted for publication 3 December 2025
Published 17 December 2025 Volume 2025:18 Pages 4631—4643
DOI https://doi.org/10.2147/DMSO.S560290
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Jae Woong Sull
Yale Tang,1,2 Shaojing Zeng,2 Xiaoyu Hou,2 Peipei Tian,1,2 Luping Ren,1– 3 Guangyao Song1– 3
1Department of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, 050017, People’s Republic of China; 2Department of Endocrinology, Hebei General Hospital, Shijiazhuang, Hebei, 050051, People’s Republic of China; 3Hebei Key Laboratory of Metabolic Diseases, Hebei General Hospital, Shijiazhuang, Hebei, 050051, People’s Republic of China
Correspondence: Guangyao Song, Email sguangyao2@163.com
Purpose: This study aims to determine apolipoprotein B-48 (ApoB48) levels before and after a high-fat diet in individuals with metabolic syndrome (MetS), and to explore its relationship with MetS. It provides new risk markers for exploring the mechanism of MetS and offers important theoretical basis and candidate targets for subsequent research.
Patients and Methods: A total of 192 adult Chinese volunteers were enrolled in this cross-sectional study. Participants were divided into control and MetS groups according to the NCEP ATP III diagnostic criteria for MetS. All participants underwent oral fat tolerance testing (OFTT). Serum concentrations of fasting and postprandial ApoB48 were measured, and their relationships with each MetS component were analyzed.
Results: Among 192 participants, 81 were diagnosed with MetS. Both fasting and postprandial ApoB48 concentrations were higher in the MetS group than in the control group (P < 0.05). The incidence of MetS increased with rising ApoB48 levels. In both groups, ApoB48 concentrations initially increased and then decreased after OFTT, peaking at 4 h postprandially, with higher peak values observed in the MetS group. Fasting and 2-h postprandial ApoB48 levels had the strongest correlations with MetS.
Conclusion: Higher ApoB48 levels before and after OFTT were positively correlated with an increased risk of MetS and were higher than those in the healthy population. Fasting ApoB48 and 2-h postprandial ApoB48 levels after a high-fat meal may be potential markers of MetS.
Keywords: high-fat diet, oral fat tolerance testing, intestinal chylomicrons, triglycerides
1Department of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, 050017, People’s Republic of China; 2Department of Endocrinology, Hebei General Hospital, Shijiazhuang, Hebei, 050051, People’s Republic of China; 3Hebei Key Laboratory of Metabolic Diseases, Hebei General Hospital, Shijiazhuang, Hebei, 050051, People’s Republic of China
Correspondence: Guangyao Song, Email sguangyao2@163.com
Purpose: This study aims to determine apolipoprotein B-48 (ApoB48) levels before and after a high-fat diet in individuals with metabolic syndrome (MetS), and to explore its relationship with MetS. It provides new risk markers for exploring the mechanism of MetS and offers important theoretical basis and candidate targets for subsequent research.
Patients and Methods: A total of 192 adult Chinese volunteers were enrolled in this cross-sectional study. Participants were divided into control and MetS groups according to the NCEP ATP III diagnostic criteria for MetS. All participants underwent oral fat tolerance testing (OFTT). Serum concentrations of fasting and postprandial ApoB48 were measured, and their relationships with each MetS component were analyzed.
Results: Among 192 participants, 81 were diagnosed with MetS. Both fasting and postprandial ApoB48 concentrations were higher in the MetS group than in the control group (P < 0.05). The incidence of MetS increased with rising ApoB48 levels. In both groups, ApoB48 concentrations initially increased and then decreased after OFTT, peaking at 4 h postprandially, with higher peak values observed in the MetS group. Fasting and 2-h postprandial ApoB48 levels had the strongest correlations with MetS.
Conclusion: Higher ApoB48 levels before and after OFTT were positively correlated with an increased risk of MetS and were higher than those in the healthy population. Fasting ApoB48 and 2-h postprandial ApoB48 levels after a high-fat meal may be potential markers of MetS.
Keywords: high-fat diet, oral fat tolerance testing, intestinal chylomicrons, triglycerides