111536
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
中重度慢性疼痛患者抑郁、焦虑及睡眠障碍相关因素：一项多中心横断面研究
Authors Guo SQ , Wang LQ, Tu JF , Yang JW , Shi GX, Yan SY, Li T, Fu Y, Zhou ZY, Ji CC, Hu H, Han LF, Liu M, Xu SF, Li M, Liu LY, Chen F, Liu CZ
Received 15 August 2025
Accepted for publication 27 November 2025
Published 16 December 2025 Volume 2025:18 Pages 6791—6805
DOI https://doi.org/10.2147/JPR.S561047
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Jonathan Greenberg
Shi-Qi Guo,1 Li-Qiong Wang,1 Jian-Feng Tu,1 Jing-Wen Yang,1 Guang-Xia Shi,1 Shi-Yan Yan,1 Tie Li,2 Yong Fu,3 Zhong-Yu Zhou,4 Chang-Chun Ji,5 Hui Hu,6 Long-Fei Han,7 Mi Liu,8 Shi-Fen Xu,9 Meng Li,10 Lan-Ying Liu,11 Feng Chen,12 Cun-Zhi Liu1
1International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, 100029, People’s Republic of China; 2The Third Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, People’s Republic of China; 3The Affiliated Hospital of Jiangxi University of Chinese Medicine, Jiangxi, People’s Republic of China; 4Hubei Province Hospital of Traditional Chinese Medicine, Hubei, People’s Republic of China; 5Shaanxi Province Hospital of Traditional Chinese Medicine, Shaanxi, People’s Republic of China; 6Dongfang Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 7Shandong University Qilu Hospital High-Tech Zone Hospital, Shandong, People’s Republic of China; 8The First Hospital of Hunan University of Chinese Medicine, Hunan, People’s Republic of China; 9Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China; 10The Second Affiliated Hospital of Anhui University of Chinese Medicine, Anhui, People’s Republic of China; 11Jiangsu Province Hospital of Chinese Medicine, Jiangsu, People’s Republic of China; 12Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China
Correspondence: Cun-Zhi Liu, School of Acupuncture and Moxibustion, Beijing University of Chinese Medicine, 11 Bei San Huan Dong Lu, Chaoyang District, Beijing, 100029, People’s Republic of China, Tel +861053912201, Fax +861053912201, Email lcz623780@126.com
Objective: This study aimed to investigate the prevalence of depression/anxiety/sleep disturbance (D/A/S), as well as factors associated with these conditions, among patients with moderate-to-severe chronic pain.
Methods: This cross-sectional study was conducted at 13 tertiary hospitals in 10 provinces, enrolling consecutive patients with chronic pain from November 2023 to May 2024. Depression was defined using the Patient Health Questionnaire-9 cutoff of 5 or higher, categories of depression were defined as none (scores: 0– 4); anxiety was defined using the Generalized Anxiety Disorder-7 cutoff of 5 or higher, categories of anxiety were defined as none (scores: 0– 4); sleep disturbance was defined as a total Pittsburgh Sleep Quality Index score of > 5, categories of sleep disturbance were defined as none (scores: 0– 5). Sociodemographic, lifestyle behaviors, and clinical characteristics were collected. Pearson correlation analysis was used to examine correlations among D/A/S. Univariate and multivariate logistic regression analyses were applied to identify factors associated with these conditions.
Results: A total of 1107 patients were analyzed. D/A/S were identified in 36.6%, 19.1%, and 46.3% of the patients with chronic pain, respectively. The co-occurrence of two or three symptoms was 12.8– 26.6%. In the multivariate analysis, patients who reported poor self-rated health (odds ratio [OR] 1.89, 95% confidence interval [CI] 1.33– 2.68) and neuroticism (OR 1.06, 95% CI 1.02– 1.09) were associated with depression. Neck pain (OR 2.60, 95% CI 1.53– 4.42), alcohol consumption (OR 1.83, 95% CI 1.12– 2.99), neuroticism (OR 1.09, 95% CI 1.05– 1.13), and pain interference (OR 1.33, 95% CI 1.17– 1.50) were correlated with anxiety. Alcohol consumption (OR 1.64, 95% CI 1.16– 2.32) and pain interference (OR 1.12, 95% CI 1.03– 1.23) were associated with sleep disturbance.
Conclusion: Among patients with chronic pain, D/A/S are prevalent and linked to distinct factors. Alcohol consumption and pain interference may be associated with both anxiety and sleep disturbance, while neuroticism may be linked to both depression and anxiety. Future systematic management of multifactorial factors may improve their mental health.
Keywords: depression, anxiety, sleep disturbance, human personality, self-rated health, chronic pain
1International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, 100029, People’s Republic of China; 2The Third Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, People’s Republic of China; 3The Affiliated Hospital of Jiangxi University of Chinese Medicine, Jiangxi, People’s Republic of China; 4Hubei Province Hospital of Traditional Chinese Medicine, Hubei, People’s Republic of China; 5Shaanxi Province Hospital of Traditional Chinese Medicine, Shaanxi, People’s Republic of China; 6Dongfang Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 7Shandong University Qilu Hospital High-Tech Zone Hospital, Shandong, People’s Republic of China; 8The First Hospital of Hunan University of Chinese Medicine, Hunan, People’s Republic of China; 9Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China; 10The Second Affiliated Hospital of Anhui University of Chinese Medicine, Anhui, People’s Republic of China; 11Jiangsu Province Hospital of Chinese Medicine, Jiangsu, People’s Republic of China; 12Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China
Correspondence: Cun-Zhi Liu, School of Acupuncture and Moxibustion, Beijing University of Chinese Medicine, 11 Bei San Huan Dong Lu, Chaoyang District, Beijing, 100029, People’s Republic of China, Tel +861053912201, Fax +861053912201, Email lcz623780@126.com
Objective: This study aimed to investigate the prevalence of depression/anxiety/sleep disturbance (D/A/S), as well as factors associated with these conditions, among patients with moderate-to-severe chronic pain.
Methods: This cross-sectional study was conducted at 13 tertiary hospitals in 10 provinces, enrolling consecutive patients with chronic pain from November 2023 to May 2024. Depression was defined using the Patient Health Questionnaire-9 cutoff of 5 or higher, categories of depression were defined as none (scores: 0– 4); anxiety was defined using the Generalized Anxiety Disorder-7 cutoff of 5 or higher, categories of anxiety were defined as none (scores: 0– 4); sleep disturbance was defined as a total Pittsburgh Sleep Quality Index score of > 5, categories of sleep disturbance were defined as none (scores: 0– 5). Sociodemographic, lifestyle behaviors, and clinical characteristics were collected. Pearson correlation analysis was used to examine correlations among D/A/S. Univariate and multivariate logistic regression analyses were applied to identify factors associated with these conditions.
Results: A total of 1107 patients were analyzed. D/A/S were identified in 36.6%, 19.1%, and 46.3% of the patients with chronic pain, respectively. The co-occurrence of two or three symptoms was 12.8– 26.6%. In the multivariate analysis, patients who reported poor self-rated health (odds ratio [OR] 1.89, 95% confidence interval [CI] 1.33– 2.68) and neuroticism (OR 1.06, 95% CI 1.02– 1.09) were associated with depression. Neck pain (OR 2.60, 95% CI 1.53– 4.42), alcohol consumption (OR 1.83, 95% CI 1.12– 2.99), neuroticism (OR 1.09, 95% CI 1.05– 1.13), and pain interference (OR 1.33, 95% CI 1.17– 1.50) were correlated with anxiety. Alcohol consumption (OR 1.64, 95% CI 1.16– 2.32) and pain interference (OR 1.12, 95% CI 1.03– 1.23) were associated with sleep disturbance.
Conclusion: Among patients with chronic pain, D/A/S are prevalent and linked to distinct factors. Alcohol consumption and pain interference may be associated with both anxiety and sleep disturbance, while neuroticism may be linked to both depression and anxiety. Future systematic management of multifactorial factors may improve their mental health.
Keywords: depression, anxiety, sleep disturbance, human personality, self-rated health, chronic pain