111536
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
硒和铅暴露与未确诊高血压患者的血压升高有关：来自 2013 - 2020 年美国国家健康与营养调查（NHANES）的研究结果
Authors Tang L , Li X, Wang Y, He Y
Received 8 July 2025
Accepted for publication 9 December 2025
Published 16 December 2025 Volume 2025:21 Pages 1093—1106
DOI https://doi.org/10.2147/VHRM.S552304
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Daniel Duprez
Li Tang,1,* Xue Li,2,* Yeyuan Wang,3 Yulei He4
1Department of Healthcare, Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, People’s Republic of China; 2Department of Pediatric Critical Care Medicine, Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, People’s Republic of China; 3Chengdu Shuangliu Yixin Sub-district Community Health Service Center, Chengdu, People’s Republic of China; 4Health Management Center, Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yulei He, Health Management Center, Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 611731, People’s Republic of China, Email 48533259@qq.com
Purpose: Prior studies on the relationship between metal exposure and blood pressure have reported inconsistent findings, potentially due to the inclusion of individuals receiving hypertension treatment. This study assessed the association between blood concentrations of selenium (Se), lead (Pb), total mercury (Hg), cadmium (Cd), and manganese (Mn) and elevated blood pressure in US adults aged 20– 60 years without a prior hypertension diagnosis. We also explored the moderating effects of age, gender and body mass index (BMI), and the mediating role of non-high-density lipoprotein cholesterol (non-HDL-C).
Methods: Data from the 2013– 2020 National Health and Nutrition Examination Survey were analyzed. Weighted logistic regression model were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs), with subgroup analyses assessing effect modification. Structural equation modelling was employed to evaluated the potential mediating effects of non-HDL-C.
Results: Among 6026 participants, 1,569 had elevated blood pressure. Adjusted analyses showed significant associations between Se and Pb and increased hypertension odds. Each 1 μg/L increase in Se corresponded to a 1% rise in odds (OR: 1.01, 95% CI: 1.00, 1.01), with those in the highest Se quintiles (Q4 and Q5) having 49% (95% CI: 1.01– 2.21) and 52% (95% CI: 1.01– 2.27) greater odds, respectively. A unit increase in log-transformed Pb was associated with a 36% increase in odds (95% CI: 1.09– 1.71), with the highest Pb quintile showing nearly double the risk (OR: 1.94; 95% CI: 1.22– 3.07). BMI significantly moderated the association with Se and Pb, albeit in different ways. Non-HDL-C mediated 36.82% of Se’s and 30.80% of Pb’s total effect on elevated blood pressure (p< 0.05).
Conclusion: In US adults without diagnosed hypertension, higher blood Se and Pb concentrations were associated with elevated blood pressure, with BMI modifying and non-HDL-C potentially and partially mediating these associations. These findings highlight the need for targeted public health strategies to limit environmental metal exposure and suggest that monitoring non-HDL-C levels in conjunction with individual metabolic profiles may support early cardiovascular risk assessment and timely intervention.
Keywords: metal exposure, blood pressure, cross-sectional study, mediation analysis
1Department of Healthcare, Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, People’s Republic of China; 2Department of Pediatric Critical Care Medicine, Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, People’s Republic of China; 3Chengdu Shuangliu Yixin Sub-district Community Health Service Center, Chengdu, People’s Republic of China; 4Health Management Center, Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yulei He, Health Management Center, Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 611731, People’s Republic of China, Email 48533259@qq.com
Purpose: Prior studies on the relationship between metal exposure and blood pressure have reported inconsistent findings, potentially due to the inclusion of individuals receiving hypertension treatment. This study assessed the association between blood concentrations of selenium (Se), lead (Pb), total mercury (Hg), cadmium (Cd), and manganese (Mn) and elevated blood pressure in US adults aged 20– 60 years without a prior hypertension diagnosis. We also explored the moderating effects of age, gender and body mass index (BMI), and the mediating role of non-high-density lipoprotein cholesterol (non-HDL-C).
Methods: Data from the 2013– 2020 National Health and Nutrition Examination Survey were analyzed. Weighted logistic regression model were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs), with subgroup analyses assessing effect modification. Structural equation modelling was employed to evaluated the potential mediating effects of non-HDL-C.
Results: Among 6026 participants, 1,569 had elevated blood pressure. Adjusted analyses showed significant associations between Se and Pb and increased hypertension odds. Each 1 μg/L increase in Se corresponded to a 1% rise in odds (OR: 1.01, 95% CI: 1.00, 1.01), with those in the highest Se quintiles (Q4 and Q5) having 49% (95% CI: 1.01– 2.21) and 52% (95% CI: 1.01– 2.27) greater odds, respectively. A unit increase in log-transformed Pb was associated with a 36% increase in odds (95% CI: 1.09– 1.71), with the highest Pb quintile showing nearly double the risk (OR: 1.94; 95% CI: 1.22– 3.07). BMI significantly moderated the association with Se and Pb, albeit in different ways. Non-HDL-C mediated 36.82% of Se’s and 30.80% of Pb’s total effect on elevated blood pressure (p< 0.05).
Conclusion: In US adults without diagnosed hypertension, higher blood Se and Pb concentrations were associated with elevated blood pressure, with BMI modifying and non-HDL-C potentially and partially mediating these associations. These findings highlight the need for targeted public health strategies to limit environmental metal exposure and suggest that monitoring non-HDL-C levels in conjunction with individual metabolic profiles may support early cardiovascular risk assessment and timely intervention.
Keywords: metal exposure, blood pressure, cross-sectional study, mediation analysis