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已发表论文
伏立康唑成功治疗奥默氏拟青霉菌血流感染：一例报告及文献综述
Authors Guo L , Li K , Huang W , Jin X , Pan S , Li C, Li Q , Yao L, Sun S, Xiong Q , Lan L, Tang C, Huang J, Zhu W, Lin N
Received 31 August 2025
Accepted for publication 2 December 2025
Published 16 December 2025 Volume 2025:18 Pages 6719—6725
DOI https://doi.org/10.2147/IDR.S564291
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 4
Editor who approved publication: Prof. Dr. Héctor Mora-Montes
Lijing Guo,1,* Kuo Li,1,* Weichen Huang,1,* Xinyi Jin,1 Shengnan Pan,1 Chang Li,1 Qianhui Li,1 Lijun Yao,1,2 Shuxin Sun,1,2 Qinchui Xiong,1,2 Liyan Lan,1,2 Chaogui Tang,1 Jingjing Huang,1 Wanji Zhu,3 Ning Lin1
1Department of Clinical Laboratory, the Affiliated Huai’an No. 1 People’s Hospital of Nanjing Medical University, Huai’an, Jiangsu, People’s Republic of China; 2Department of Kangda College, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China; 3Department of Gastrointestinal Surgery, the Affiliated Huai’an No. 1 People’s Hospital of Nanjing Medical University, Huai’an, Jiangsu, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Ning Lin, Email linning_paper@163.com Wanji Zhu, Email zhuwanjisport@163.com
Abstract: Kodamaea ohmeri is an emerging opportunistic yeast pathogen frequently misidentified as Candida, posing significant diagnostic challenges. This report describes a case of K. ohmeri bloodstream infection in a 70-year-old female with poorly controlled diabetes following radical gastrectomy. Despite broad-spectrum antibacterial therapy for postoperative complications, she developed persistent fever. Blood cultures identified K. ohmeri, and antifungal susceptibility testing (AST) revealed a low voriconazole minimum inhibitory concentration (0.06 μg/mL), prompting targeted therapy that led to the clearance of fungemia and full clinical recovery. This case underscores the critical importance of rapid pathogen identification and AST-directed therapy in managing life-threatening K. ohmeri infections.
Keywords: Kodamaea ohmeri, bloodstream infection, voriconazole, antifungal, susceptibility testing, case report
1Department of Clinical Laboratory, the Affiliated Huai’an No. 1 People’s Hospital of Nanjing Medical University, Huai’an, Jiangsu, People’s Republic of China; 2Department of Kangda College, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China; 3Department of Gastrointestinal Surgery, the Affiliated Huai’an No. 1 People’s Hospital of Nanjing Medical University, Huai’an, Jiangsu, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Ning Lin, Email linning_paper@163.com Wanji Zhu, Email zhuwanjisport@163.com
Abstract: Kodamaea ohmeri is an emerging opportunistic yeast pathogen frequently misidentified as Candida, posing significant diagnostic challenges. This report describes a case of K. ohmeri bloodstream infection in a 70-year-old female with poorly controlled diabetes following radical gastrectomy. Despite broad-spectrum antibacterial therapy for postoperative complications, she developed persistent fever. Blood cultures identified K. ohmeri, and antifungal susceptibility testing (AST) revealed a low voriconazole minimum inhibitory concentration (0.06 μg/mL), prompting targeted therapy that led to the clearance of fungemia and full clinical recovery. This case underscores the critical importance of rapid pathogen identification and AST-directed therapy in managing life-threatening K. ohmeri infections.
Keywords: Kodamaea ohmeri, bloodstream infection, voriconazole, antifungal, susceptibility testing, case report