111536
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
精神疾病家族史作为卒中后抑郁的风险因素：一项系统评价和荟萃分析
Authors Zhang H, Wang Z , Li Z, Ma Q, Li G
Received 15 October 2025
Accepted for publication 2 December 2025
Published 16 December 2025 Volume 2025:21 Pages 2805—2816
DOI https://doi.org/10.2147/NDT.S572789
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Roger Pinder
Hao Zhang,1,* Zhe Wang,2,* Zhiqi Li,2 Qingxiong Ma,1 Guo Li3
1The Second Clinical College, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, People’s Republic of China; 2The First Clinical College, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, People’s Republic of China; 3Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Guo Li, Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, Hubei, 430030, People’s Republic of China, Tel +86 139 9554 2002, Email liguo@tjh.tjmu.edu.cn
Background: Currently, the evidence regarding the relationship between family history of psychiatric disorders and post-stroke depression (PSD) is inconsistent. Some observational studies did not consider a positive family history of psychiatric disorders as a definite risk factor. Furthermore, the bulk of research on the association between family history of psychiatric disorders and PSD comes from earlier studies that were frequently constrained by modest sample sizes. Therefore, we plan to use a meta-analysis approach to study this correlation.
Methods: We systematically reviewed the studies related to PSD and family history of psychiatric disorders from PubMed, Embase and EBSCO. The studies eligible for inclusion were peer-reviewed observational studies that reported an odds ratio or contained sufficient data to enable its calculation. We conducted a random-effects meta-analysis of the proportion of PSD patients with a reported positive family history of psychiatric disorders.
Results: Eleven studies published between 1990 and 2020 were included, comprising data on stroke patients. The meta-analysis revealed an elevated odds ratio of 1.73 (95% CI: 1.29– 2.33; I2 = 6.1%) for the development of PSD among stroke patients with a familial predisposition to psychiatric disorders. The findings of subgroup, sensitivity, and meta-regression analyses concurred with the primary analysis. According to GRADE, the overall certainty of the evidence was judged as moderate.
Conclusion: This study revealed moderate certainty of evidence, indicating that stroke patients with family history of psychiatric disorders have approximately a 1.73-fold risk of developing PSD compared to those without such a family history.
Keywords: Post-stroke depression, Meta-analysis, Family history of psychiatric disorders, Cerebrovascular disease
1The Second Clinical College, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, People’s Republic of China; 2The First Clinical College, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, People’s Republic of China; 3Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Guo Li, Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, Hubei, 430030, People’s Republic of China, Tel +86 139 9554 2002, Email liguo@tjh.tjmu.edu.cn
Background: Currently, the evidence regarding the relationship between family history of psychiatric disorders and post-stroke depression (PSD) is inconsistent. Some observational studies did not consider a positive family history of psychiatric disorders as a definite risk factor. Furthermore, the bulk of research on the association between family history of psychiatric disorders and PSD comes from earlier studies that were frequently constrained by modest sample sizes. Therefore, we plan to use a meta-analysis approach to study this correlation.
Methods: We systematically reviewed the studies related to PSD and family history of psychiatric disorders from PubMed, Embase and EBSCO. The studies eligible for inclusion were peer-reviewed observational studies that reported an odds ratio or contained sufficient data to enable its calculation. We conducted a random-effects meta-analysis of the proportion of PSD patients with a reported positive family history of psychiatric disorders.
Results: Eleven studies published between 1990 and 2020 were included, comprising data on stroke patients. The meta-analysis revealed an elevated odds ratio of 1.73 (95% CI: 1.29– 2.33; I2 = 6.1%) for the development of PSD among stroke patients with a familial predisposition to psychiatric disorders. The findings of subgroup, sensitivity, and meta-regression analyses concurred with the primary analysis. According to GRADE, the overall certainty of the evidence was judged as moderate.
Conclusion: This study revealed moderate certainty of evidence, indicating that stroke patients with family history of psychiatric disorders have approximately a 1.73-fold risk of developing PSD compared to those without such a family history.
Keywords: Post-stroke depression, Meta-analysis, Family history of psychiatric disorders, Cerebrovascular disease