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已发表论文
患者自控镇痛联合自我管理训练对慢性膝关节疼痛糖尿病患者疼痛调节的影响
Authors Zhao X, Huang Z, Su Z, Zhou H, Chen L
Received 14 May 2025
Accepted for publication 10 October 2025
Published 16 December 2025 Volume 2025:18 Pages 6769—6777
DOI https://doi.org/10.2147/JPR.S537565
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Professor King Hei Stanley Lam
Xizhen Zhao,1 Zhihong Huang,2 Zhongliang Su,1 Huijie Zhou,2 Lingmin Chen3
1Department of Orthopedics, Wenzhou People’s Hospital, Wenzhou Maternal and Child Health Care Hospital, The Third Clinical Institute Affiliated To Wenzhou Medical University, The Third Affiliated Hospital of Shanghai University, Wenzhou, Zhejiang Province, 325000, People’s Republic of China; 2Wenzhou People’s Hospital, Wenzhou Maternal and Child Health Care Hospital, The Third Clinical Institute Affiliated To Wenzhou Medical University, The Third Affiliated Hospital of Shanghai University, Wenzhou, Zhejiang Province, 325000, People’s Republic of China; 3Department of Urology Surgery, Wenzhou People’s Hospital, Wenzhou Maternal and Child Health Care Hospital, The Third Clinical Institute Affiliated To Wenzhou Medical University, The Third Affiliated Hospital of Shanghai University, Wenzhou, Zhejiang Province, 325000, People’s Republic of China
Correspondence: Lingmin Chen, Department of Urology Surgery, Wenzhou People’s Hospital, Wenzhou Maternal and Child Health Care Hospital, The Third Clinical Institute Affiliated To Wenzhou Medical University, The Third Affiliated Hospital of Shanghai University, Wenzhou, Zhejiang Province, 325000, People’s Republic of China, Email Jancyzhao2008@163.com
Background: Chronic knee osteoarthritis is a debilitating condition characterized by persistent knee pain and functional impairment. This study aimed to evaluate the impact of Patient-Controlled Analgesia (PCA) combined with self-management training on postoperative pain management in diabetic and non-diabetic patients with chronic knee pain.
Methods: We conducted a cohort study of 100 patients (40 diabetic, 60 non-diabetic) undergoing knee replacement surgery. Participants were assigned to receive either PCA with self-management training or standard care. Pain was assessed using VAS scores, and self-management ability was evaluated with a preliminary DSSMET. The impact of PCA and diabetes status on these outcomes was evaluated using multivariate regression models (multiple linear and logistic), which adjusted for confounding variables. All analyses were performed in SPSS 25.0 with statistical significance set at p < 0.05.
Results: The results showed that baseline characteristics showed no age difference between groups, but diabetic patients had shorter discharge times and higher blood glucose levels (P< 0.001). VAS scores indicated higher pain in diabetic patients (P< 0.001), with significant pain reduction in the PCA subgroup (P=0.036). The DSSMET showed good reliability (Cronbach’s α =0.87) and validity (four-factor structure). Furthermore, PCA was associated with effective pain relief, with this effect being most pronounced in diabetic patients.
Conclusion: This study developed a preliminary tool to evaluate self-management ability in chronic knee pain patients and investigated the effect of PCA combined with self-management training on pain relief. The results suggest that this combined intervention may effectively relieve pain, particularly in diabetic patients. Furthermore, high patient engagement and adherence indicate good acceptability of the combined PCA and self-management protocol.
Keywords: diabetes mellitus, osteoarthritis, knee, pain management, rehabilitation, self-management
1Department of Orthopedics, Wenzhou People’s Hospital, Wenzhou Maternal and Child Health Care Hospital, The Third Clinical Institute Affiliated To Wenzhou Medical University, The Third Affiliated Hospital of Shanghai University, Wenzhou, Zhejiang Province, 325000, People’s Republic of China; 2Wenzhou People’s Hospital, Wenzhou Maternal and Child Health Care Hospital, The Third Clinical Institute Affiliated To Wenzhou Medical University, The Third Affiliated Hospital of Shanghai University, Wenzhou, Zhejiang Province, 325000, People’s Republic of China; 3Department of Urology Surgery, Wenzhou People’s Hospital, Wenzhou Maternal and Child Health Care Hospital, The Third Clinical Institute Affiliated To Wenzhou Medical University, The Third Affiliated Hospital of Shanghai University, Wenzhou, Zhejiang Province, 325000, People’s Republic of China
Correspondence: Lingmin Chen, Department of Urology Surgery, Wenzhou People’s Hospital, Wenzhou Maternal and Child Health Care Hospital, The Third Clinical Institute Affiliated To Wenzhou Medical University, The Third Affiliated Hospital of Shanghai University, Wenzhou, Zhejiang Province, 325000, People’s Republic of China, Email Jancyzhao2008@163.com
Background: Chronic knee osteoarthritis is a debilitating condition characterized by persistent knee pain and functional impairment. This study aimed to evaluate the impact of Patient-Controlled Analgesia (PCA) combined with self-management training on postoperative pain management in diabetic and non-diabetic patients with chronic knee pain.
Methods: We conducted a cohort study of 100 patients (40 diabetic, 60 non-diabetic) undergoing knee replacement surgery. Participants were assigned to receive either PCA with self-management training or standard care. Pain was assessed using VAS scores, and self-management ability was evaluated with a preliminary DSSMET. The impact of PCA and diabetes status on these outcomes was evaluated using multivariate regression models (multiple linear and logistic), which adjusted for confounding variables. All analyses were performed in SPSS 25.0 with statistical significance set at p < 0.05.
Results: The results showed that baseline characteristics showed no age difference between groups, but diabetic patients had shorter discharge times and higher blood glucose levels (P< 0.001). VAS scores indicated higher pain in diabetic patients (P< 0.001), with significant pain reduction in the PCA subgroup (P=0.036). The DSSMET showed good reliability (Cronbach’s α =0.87) and validity (four-factor structure). Furthermore, PCA was associated with effective pain relief, with this effect being most pronounced in diabetic patients.
Conclusion: This study developed a preliminary tool to evaluate self-management ability in chronic knee pain patients and investigated the effect of PCA combined with self-management training on pain relief. The results suggest that this combined intervention may effectively relieve pain, particularly in diabetic patients. Furthermore, high patient engagement and adherence indicate good acceptability of the combined PCA and self-management protocol.
Keywords: diabetes mellitus, osteoarthritis, knee, pain management, rehabilitation, self-management