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已发表论文
醒脑开窍针刺联合四妙丸对良性前列腺增生小鼠的治疗作用
Authors Luo Z , Yang X, Zhang J, Zhang B, Zhao Q, Cui L, Bo H
Received 5 July 2025
Accepted for publication 27 November 2025
Published 15 December 2025 Volume 2025:18 Pages 17663—17675
DOI https://doi.org/10.2147/JIR.S546797
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Professor Ning Quan
Zhiyuan Luo,1,* Xiaomei Yang,2,* Jingting Zhang,1 Bingqian Zhang,1 Qingjie Zhao,2 Longtao Cui,3 Huajun Bo1
1Department of Acupuncture and Massage, Shanghai Fourth People’s Hospital, Tongji University, Shanghai, 200434, People’s Republic of China; 2State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shanghai Frontiers Science Center for TCM Chemical Biology, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People’s Republic of China; 3School of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Longtao Cui, School of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People’s Republic of China, Email 18302189968@139.com Huajun Bo, Department of Acupuncture and Massage, Shanghai Fourth People’s Hospital, Tongji University, Shanghai, 200434, People’s Republic of China, Email 13918710140@163.com
Purpose: Benign prostatic hyperplasia (BPH) is a common condition in older men, but treatment is often associated with complications and high recurrence rates. Previous clinical studies have shown that Brain Awakening and Mind Opening (BAMO) acupuncture and Simiao Pill can improve lower urinary tract symptoms in patients with BPH. This study explores the potential mechanisms behind these treatment methods for BPH using a mice model.
Methods: Six-week-old ICR male mice were divided into 5 groups (n=10). The Mice were injected subcutaneously with TP (5mg/kg/d) / corn oil (equal volume) for 28 days to establish a BPH model and a control group. After successful modelling, the mice were treated with distilled water for 21 days, while the BAMO acupuncture group, the Simiao pill group, and the mixed group were treated accordingly (BAMO acupuncture at Neiguan (PC6), Sanyinjiao (SP6), and Guanyuan (CV4) acupoints for 30 minutes every other day, or Simiao pill once a day).
Results: BAMO acupuncture, Simiao pills, and their combination effectively reduced prostate hyperplasia in mice. The observed therapeutic effects likely involve multiple mechanisms: suppression of dihydrotestosterone (DHT) synthesis via reduced testosterone levels and downregulated SRD5A2 expression (P< 0.01), promotion of prostate cell apoptosis (indicated by an increased BAX/BCL-2 ratio, P< 0.05), and mitigation of inflammation through decreased levels of pro-inflammatory cytokines IL-6 and TNF-α (P< 0.05).
Conclusion: BAMO acupuncture and Simiao pill can restore normal prostate tissue structure in mice through multiple mechanisms: (1) reducing DHT production; (2) promoting apoptosis; (3) reducing inflammatory responses. Future studies could further investigate the hormonal regulation and apoptosis of BAMO acupuncture in mice.
Keywords: BAMO acupuncture, Simiao pill, BPH, mechanism study
1Department of Acupuncture and Massage, Shanghai Fourth People’s Hospital, Tongji University, Shanghai, 200434, People’s Republic of China; 2State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shanghai Frontiers Science Center for TCM Chemical Biology, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People’s Republic of China; 3School of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Longtao Cui, School of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People’s Republic of China, Email 18302189968@139.com Huajun Bo, Department of Acupuncture and Massage, Shanghai Fourth People’s Hospital, Tongji University, Shanghai, 200434, People’s Republic of China, Email 13918710140@163.com
Purpose: Benign prostatic hyperplasia (BPH) is a common condition in older men, but treatment is often associated with complications and high recurrence rates. Previous clinical studies have shown that Brain Awakening and Mind Opening (BAMO) acupuncture and Simiao Pill can improve lower urinary tract symptoms in patients with BPH. This study explores the potential mechanisms behind these treatment methods for BPH using a mice model.
Methods: Six-week-old ICR male mice were divided into 5 groups (n=10). The Mice were injected subcutaneously with TP (5mg/kg/d) / corn oil (equal volume) for 28 days to establish a BPH model and a control group. After successful modelling, the mice were treated with distilled water for 21 days, while the BAMO acupuncture group, the Simiao pill group, and the mixed group were treated accordingly (BAMO acupuncture at Neiguan (PC6), Sanyinjiao (SP6), and Guanyuan (CV4) acupoints for 30 minutes every other day, or Simiao pill once a day).
Results: BAMO acupuncture, Simiao pills, and their combination effectively reduced prostate hyperplasia in mice. The observed therapeutic effects likely involve multiple mechanisms: suppression of dihydrotestosterone (DHT) synthesis via reduced testosterone levels and downregulated SRD5A2 expression (P< 0.01), promotion of prostate cell apoptosis (indicated by an increased BAX/BCL-2 ratio, P< 0.05), and mitigation of inflammation through decreased levels of pro-inflammatory cytokines IL-6 and TNF-α (P< 0.05).
Conclusion: BAMO acupuncture and Simiao pill can restore normal prostate tissue structure in mice through multiple mechanisms: (1) reducing DHT production; (2) promoting apoptosis; (3) reducing inflammatory responses. Future studies could further investigate the hormonal regulation and apoptosis of BAMO acupuncture in mice.
Keywords: BAMO acupuncture, Simiao pill, BPH, mechanism study