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已发表论文
时间加权累积高敏 C 反应蛋白与心脏传导阻滞风险：一项前瞻性队列研究结果
Authors Zhang M, Shi D, Chen Y, Liao Y, Liu Z, Fu R, Bian Y, Chen S, Zhao H, He H , Zu C, Liu C, Huo H, Wu S , Wu Y
Received 18 June 2025
Accepted for publication 6 December 2025
Published 14 December 2025 Volume 2025:18 Pages 17477—17493
DOI https://doi.org/10.2147/JIR.S547484
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 5
Editor who approved publication: Dr Durga Misra
Mo Zhang,1,2,* Dou Shi,1,* Yixiu Chen,2,3 Yicheng Liao,2,3 Zhihui Liu,2,3 Renjie Fu,2,3 Yufeng Bian,2,3 Shuohua Chen,2 Haiyan Zhao,2 Honghong He,2 Changhao Zu,2 Chunlu Liu,2 Hongqiu Huo,2 Shouling Wu,2 Yuntao Wu2
1Graduate School, Hebei North University, Zhangjiakou City, Hebei Province, 075000, People’s Republic of China; 2Department of Cardiology, Kailuan General Hospital, Tangshan City, Hebei Province, 063000, People’s Republic of China; 3Graduate School, North China University of Science and Technology, Tangshan City, Hebei Province, 063210, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yuntao Wu, Department of Cardiology, Kailuan General Hospital, No. 57 Xinhua East Road, Tangshan City, Hebei Province, 063000, People’s Republic of China, Tel +8613933305222, Email wyt0086@163.com
Purpose: Chronic low-grade inflammation is increasingly recognized as a contributing factor in the development of cardiovascular events. This study aimed to evaluate the association between time-weighted cumulative exposure to high-sensitivity C-reactive protein (cumhsCRP) and the risk of new-onset cardiac conduction block (CCB).
Patients and Methods: A total of 48,703 participants from a prospective community-based cohort were included. The average exposure time for cumhsCRP was 6.36 years. Participants were stratified into two groups: cumhsCRP < 2 mg/L and cumhsCRP ≥ 2 mg/L. The incidence of new-onset cardiac conduction block and its subtypes was identified through standard 12-lead electrocardiograms. Cox proportional hazards models were used to assess the relationship between cumhsCRP levels and incident CCB risk, adjusting for potential confounders. A restricted cubic spline curve further explored the dose-response pattern.
Results: During a mean follow-up period of 9.24 years, 803 cases of new-onset CCB were documented (incidence rate: 1.65%). After full multivariable adjustment, individuals in the cumhsCRP ≥ 2 mg/L group exhibited a significantly higher risk of CCB compared to those with cumhsCRP < 2 mg/L (HR: 1.24, 95% CI: 1.07– 1.44). The RCS analysis suggested a linear association between log-transformed cumhsCRP and CCB risk (p for non-linearity = 0.294).
Conclusion: Elevated cumulative exposure to high-sensitivity C-reactive protein is independently associated with an increased risk of developing CCB, especially left bundle branch block and left anterior fascicular block. This study will provide new insights into the prevention of CCB.
Keywords: inflammation, high-sensitivity C-reactive protein, cumulative exposure, cardiac conduction block
1Graduate School, Hebei North University, Zhangjiakou City, Hebei Province, 075000, People’s Republic of China; 2Department of Cardiology, Kailuan General Hospital, Tangshan City, Hebei Province, 063000, People’s Republic of China; 3Graduate School, North China University of Science and Technology, Tangshan City, Hebei Province, 063210, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yuntao Wu, Department of Cardiology, Kailuan General Hospital, No. 57 Xinhua East Road, Tangshan City, Hebei Province, 063000, People’s Republic of China, Tel +8613933305222, Email wyt0086@163.com
Purpose: Chronic low-grade inflammation is increasingly recognized as a contributing factor in the development of cardiovascular events. This study aimed to evaluate the association between time-weighted cumulative exposure to high-sensitivity C-reactive protein (cumhsCRP) and the risk of new-onset cardiac conduction block (CCB).
Patients and Methods: A total of 48,703 participants from a prospective community-based cohort were included. The average exposure time for cumhsCRP was 6.36 years. Participants were stratified into two groups: cumhsCRP < 2 mg/L and cumhsCRP ≥ 2 mg/L. The incidence of new-onset cardiac conduction block and its subtypes was identified through standard 12-lead electrocardiograms. Cox proportional hazards models were used to assess the relationship between cumhsCRP levels and incident CCB risk, adjusting for potential confounders. A restricted cubic spline curve further explored the dose-response pattern.
Results: During a mean follow-up period of 9.24 years, 803 cases of new-onset CCB were documented (incidence rate: 1.65%). After full multivariable adjustment, individuals in the cumhsCRP ≥ 2 mg/L group exhibited a significantly higher risk of CCB compared to those with cumhsCRP < 2 mg/L (HR: 1.24, 95% CI: 1.07– 1.44). The RCS analysis suggested a linear association between log-transformed cumhsCRP and CCB risk (p for non-linearity = 0.294).
Conclusion: Elevated cumulative exposure to high-sensitivity C-reactive protein is independently associated with an increased risk of developing CCB, especially left bundle branch block and left anterior fascicular block. This study will provide new insights into the prevention of CCB.
Keywords: inflammation, high-sensitivity C-reactive protein, cumulative exposure, cardiac conduction block