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已发表论文
精准建模咳嗽变异性哮喘：标准化小鼠模型、多维度评估及转化应用
Authors Ma X, Ma X, Li X, Ma L , Peng X, Zhou X
Received 13 October 2025
Accepted for publication 7 December 2025
Published 13 December 2025 Volume 2025:18 Pages 1743—1760
DOI https://doi.org/10.2147/JAA.S574008
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Amrita Dosanjh
Xin Ma,1,2 Xizhi Ma,1 Xiaopo Li,1 Long Ma,1 Xuezhen Peng,1 Xiaotao Zhou1
1School of Basic Medical Sciences, Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, People’s Republic of China; 2Department of Clinical Laboratory, Urumqi Friendship Hospital, Urumqi, Xinjiang Uygur Autonomous Region, People’s Republic of China
Correspondence: Xiaotao Zhou, Xinjiang Key Laboratory of Molecular Biology for Endemic Disease, School of Basic Medical Sciences, Xinjiang Medical University, 567 Shangde North Road, Shuimogou District, Urumqi, Xinjiang Uygur Autonomous Region, 830000, People’s Republic of China, Email xiaotaozhou@xjmu.edu.cn
Abstract: Cough-variant asthma (CVA), a distinct asthma phenotype characterized by chronic cough as the predominant symptom, presents unique clinical and pathophysiological features. The development of accurate murine models is essential for elucidating its underlying mechanisms and evaluating therapeutic interventions. While animal models remain indispensable tools for studying human disease pathogenesis, current bronchial asthma models inadequately recapitulate CVA-specific pathology. Notably, CVA represents the most common etiology of chronic cough in children and shares core pathogenic mechanisms with classic asthma—including chronic airway inflammation, airway hyperresponsiveness (AHR), and remodeling. Despite established protocols for typical asthma modeling, standardized CVA-specific models are lacking. This review synthesizes current methodologies for establishing CVA murine models, evaluates modeling success criteria, and analyzes commonly employed sensitizers/induction approaches. We further examine physiological, immunological, and molecular assessment parameters, proposing a comprehensive evaluation framework based on inflammatory cell profiles, AHR, and cytokine expression. Such standardization is critical for advancing precision in CVA model development.
Keywords: cough-variant asthma, murine models, model development, assessment criteria
1School of Basic Medical Sciences, Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, People’s Republic of China; 2Department of Clinical Laboratory, Urumqi Friendship Hospital, Urumqi, Xinjiang Uygur Autonomous Region, People’s Republic of China
Correspondence: Xiaotao Zhou, Xinjiang Key Laboratory of Molecular Biology for Endemic Disease, School of Basic Medical Sciences, Xinjiang Medical University, 567 Shangde North Road, Shuimogou District, Urumqi, Xinjiang Uygur Autonomous Region, 830000, People’s Republic of China, Email xiaotaozhou@xjmu.edu.cn
Abstract: Cough-variant asthma (CVA), a distinct asthma phenotype characterized by chronic cough as the predominant symptom, presents unique clinical and pathophysiological features. The development of accurate murine models is essential for elucidating its underlying mechanisms and evaluating therapeutic interventions. While animal models remain indispensable tools for studying human disease pathogenesis, current bronchial asthma models inadequately recapitulate CVA-specific pathology. Notably, CVA represents the most common etiology of chronic cough in children and shares core pathogenic mechanisms with classic asthma—including chronic airway inflammation, airway hyperresponsiveness (AHR), and remodeling. Despite established protocols for typical asthma modeling, standardized CVA-specific models are lacking. This review synthesizes current methodologies for establishing CVA murine models, evaluates modeling success criteria, and analyzes commonly employed sensitizers/induction approaches. We further examine physiological, immunological, and molecular assessment parameters, proposing a comprehensive evaluation framework based on inflammatory cell profiles, AHR, and cytokine expression. Such standardization is critical for advancing precision in CVA model development.
Keywords: cough-variant asthma, murine models, model development, assessment criteria